Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb

Environmental Toxicology and Pharmacology

Volumn 28, Issue 2, 2009, Pages 179-191

  Pelekis, M ^a   Emond, C ^a  

^a Pelekis Group   (United States)

Author keywords

Aldicarb; Physiological model; Risk assessment; Uncertainty factors

Indexed keywords

ACETYLCHOLINESTERASE; ALDICARB;

ACCURACY; ADULT; AGED; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; ERYTHROCYTE; HEART OUTPUT; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; LIVER MICROSOME; MALE; NONHUMAN; NORMAL HUMAN; OXIDATION; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROCESS DEVELOPMENT; RAT; SIMULATION; SPECIES DIFFERENCE; TOXICOKINETICS;

RATTUS;

EID: 67650263595     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2009.04.002     Document Type: Article

References (49)

1. Aldridge W.H., and Magos L. Carbamates Thiocarbamates and Thiocarbamtes (1978), Commission of the European Communities, Luxembourg
2. Altman P.L., and Dittmer D.S. Growth including reproduction and morphological development. Fed. Proc. (1962) 337-366
3. Andersen M.E. Mechanistic toxicology research and biologically-based modeling: partners for improving quantitative risk assessments. CITT Activities 12 (1992) 1-8
4. Andrawes N.R., Dorough H.W., and Lindqiust D.A. Degradation and elimination of Temik in rats. J. Agric. Food Chem. 60 (1967) 979-987
5. Baron R.L., and Merriam T.L. Toxicology of Aldicarb. Rev. Environ. Contam. Toxicol. 105 (1988) 1-70
6. Bird A.P.G.W., Leavitt R.A., and Rose L.M. Dynamics of aldicarb soil residues associated with Pratylenchus penetrans control in dry bean production. Plant Dis. 68 10 (1984) 873-874
7. Biscoff K.B., and Brown R.G. Drug distribution in mammals. Chem. Eng. Prog. Symp. 62 (1966) 33-45
8. Bull D.L., Lindquist D.A., and Coppedge J.R. Metabolism of 2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl) oxime (Temik, UC-21149) in insects. J. Agric. Food Chem. 15 (1967) 610-616
9. Cambon C., Declume C., and Derache R. Effect of the insecticide carbamate derivatives (carbofuran, primicarb, aldicarb) in the activity of acetylcholinesterase in tissues from pregnant rats and foetuses. Toxicol. Appl. Pharmacol. 49 (1979) 203-208
10. Carpenter, C.P., Smyth, H.F., 1965. Recapitulation of Toxicodynamics and acute toxicity studies on Temic. Mellon Institute Report No. 28-78. EPA Pesticide petition No. 9F0798.
11. Clewell III H.J., and Jarnot B.M. Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene. Risk Anal. 14 3 (1994) 265-276
12. Cope, O.E., Romine, R.R., 1973. Temic Aldicarb pesticide. Results of aldicarb ingestion and exposure studies with humans and results of monitoring human exposure in working environments. Unpublished study. File No. 18269. Union Carbide Agricultural Co. Project No. 111A13, 116A16. File No. 18269.
13. DePass L.R., Weaver E.V., and Mirro E.J. Aldicarb sulfoxide/ aldicarb sulfone mixture in drinking water of rats: effects on growth and acetylcholinesterase activity. J. Toxicol. Environ. Health 16 (1985) 163-172
14. Gaines T.B. Acute toxicity of pesticides. Toxicol. Appl. Pharmacol. 14 (1969) 515-534
15. Gupta R., and Dettbarn W.D. Role of carboxylesterases in the prevention and potentiation of N-methylcarbamate toxicity. Chem. Biol. Int. 87 (1993) 295-303
16. Haines, R.G., 1971. Ingestion of aldicarb by human volunteers: a controlled study of the effects of aldicarb on man. Unpublished study. Union Carbide Agricultural Co., Terryton, NY.
17. Hastings F.L., Main A.R., and Iverson F. Carbamylation and affinity constants of some carbamate inhibitors of acetylcholinesterase and their relation to analogous substrate constants. J. Agric. Food Chem. 18 (1970) 497-502
18. Houston J.B., Upshall D.G., and Bridges J.W. Further studies using carbamate esters as model compounds to investigate the role of lipophilicity in the gastrointestinal absorption of foreign compounds. J. Pharmacol. Exp. Ther. 195 (1975) 67-72
19. ILSI. Physiological Parameter Values for PBTK Models (1994), International Life Sciences Institute, Risk Science Institute, Washington, DC
20. IRIS. Integrated Risk Information System (1996), Aldicarb, USEPA
21. Iverson F., and Main A.R. Effect of charge on the carbamylation and binding constants of eel acetylcholinesterase in reaction with neostigmine and related carbamates. Biochemistry 8 (1969) 1889-1904
22. Johnson C.D., and Russell R.L. A rapid radiometric assay for cholinesterase suitable for multiple determinations. Anal. Biochem. 64 (1975) 229-238
23. Kaloyanova F.P., and El Batawi M.A. Human Toxicology of Pesticides (1991), CRC Press, Boca Raton
24. Knaak J.B., Tallant M.J., and Sullivan L.J. The metabolism of 2-methyl-2-(methylthio) propionaldehyde O-(methylcarbamoyl)oxime in the rat. J. Agric. Food Chem. 14 (1966) 573-578
25. Kuhr R.J., and Dorough H.W. Carbamate Insecticides: Chemistry, Biochemistry and Toxicology (1976), CRC Press, Boca Raton, FL
26. Long C. Biochemists' Handbook (1961), Van Nostrand Reinhold Co., NY
27. Martin H., and Worthing C.R. Pesticide Manual, British Crop Protection Council (1977), Worcestershire, England
28. Maxwell D.M., Len D.E., Groff W., Kaminski A.A., and Froehlich H.L. The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in the rats. Toxicol. Appl. Pharmacol. 88 (1987) 66-76
29. Norstrandt A.C., Duncan J.A., and Padilla S. A modified spectrophotometric method appropriate for measuring cholinesterase activity in tissue from carbaryl-treated animals. Fundam. Appl. Pharmacol. 21 (1993) 196-203
30. O'Brien R.D., Hilton B.D., and Gilmour L. The reaction of carbamates with cholinesterase. Mol. Pharmacol. 2 (1966) 593
31. Padilla S., and Hooper M.J. Cholinesterase measurements in tissues from-carbamate-treated animals: cautions and recommendations. Proceedings of the U.S. EPA Workshop on Cholinesterase Methodologies. Office of Pesticides Programs, U.S. Environmental Protection Agency, Washington, DC (1992) 63-81
32. Pelekis M., Poulin P., and Krishnan K. An approach for incorporating tissue composition data into physiologically based pharmacokinetic models. Toxicol. Ind. Health 11 5 (1995) 511-522
33. Pelekis M., and Krishnan K. Determination of the rate of aldicarb sulphoxidation in rat liver, kidney and lung microsomes. Xenobiotica 27 11 (1997) 1113-1120
34. Poulin P., and Krishnan K. A biologically-based algorithm for predicting human tissue:blood partition coefficients of organic chemicals. Hum. Exp. Toxicol. 14 (1995) 273-280
35. Poulin P., and Krishnan K. An algorithm for predicting tissue:blood partition coefficients of organic chemicals. J. Toxicol. Environ. Health 46 (1995) 117-129
36. Poulin P., and Krishnan K. A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals. Toxicol. Appl. Pharmacol. 136 (1996) 126-130
37. Reiner E., and Aldridge W.N. Effects of pH on inhibitionn and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Biochem. J. 105 (1967) 171
38. Renwick A.G. Safety factors and establishment of acceptable daily intakes. Food Addit. Contam. 8 (1991) 135-150
39. Renwick A.G. Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10 (1993) 275-305
40. Rhone-Poulenc, 1992. A safety and tolerability study of aldicarb at various dose levels in healthy male and female volunteers. Inveresk Clinical Research Report No. 7786.
41. Satoh T., and Hosokawa M. Molecular aspects of carboxylesterase isoforms in comparison within other esterases. Toxicol. Lett. 82/83 (1995) 439-445
42. US Environmental Protection Agency, 1988. Aldicarb Special Review Technical Support Document. Office of Pesticides and Toxic Substances, Washington, DC, June.
43. US Environmental Protection Agency, 1989. Method 531.1. Measurement of N-methycarbamates in water by direct aqueous injection HPLC with post column derivatazation, Environmental Monitoring Systems Laboratory, Office of Research and Development, Cincinnati, Ohio.
44. US Environmental Protection Agency, 1994. Methods for derivation of reference concentrations and application of inhalation dosimetry. Research Triangle ParK, NC: Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, EPA/600/8-90/066F.
45. Venkataraman B.V., and Naga Rani M.A. Species variation in the specificity of cholinesterases in human and rat blood samples. Indian J. Physiol. Pharmacol. 38 (1994) 211-213
46. Weiden M.H.J., Moorfield H.H., and Payne L.K. O-(methyl-carbomyl)-oximes: a class of carbamate insecticides-Acarides. J. Econ. Entomol. 58 (1965) 154-155
47. Wilkinson, C.F., Babish, J.G., Lemley, A.T., Doderlund, D.M., 1983. A toxicological evaluation of aldicarb and its metabolites in relation to the potential human health impact of aldicarb residues in Long Island ground water. New York, Cornell University, Committee from the Institute for Comparative and Environmental Toxicology (Unpublished report).
48. World Health Organization. Aldicarb, Environmental Health Perspectives 121 (1991) p. 20
49. World Health Organization 2005. Chemical-specific adjustment factors for interspecies differences and human variability: Guidance document for use in dose/concentration-response assessment.