Rapid structure elucidation of drug degradation products using mechanism-based stress studies in conjunction with LC-MSn and NMR spectroscopy: identification of a photodegradation product of betamethasone dipropionate

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 3, 2009, Pages 275-280

  Lin, Mingxiang ^a   Li, Min ^a   Buevich, Alexei V ^a   Osterman, Rebecca ^a   Rustum, Abu M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Betamethasone dipropionate; LC MS; Lumibetamethasone dipropionate; NMR; Photodegradation; Stress study

Indexed keywords

BETAMETHASONE DIPROPIONATE; DRUG METABOLITE; LUMIBETAMETHASONE DIPROPIONATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DEGRADATION; DRUG DETERMINATION; DRUG IMPURITY; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTODEGRADATION; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS; BETAMETHASONE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY;

EID: 67650236139     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.04.004     Document Type: Article

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