Oct-1 functions as a transactivator in the hormonal induction of β-casein gene expression

Molecular and Cellular Biochemistry

Volumn 328, Issue 1-2, 2009, Pages 93-99

  Dong, Bing ^a,b   Huang, Chengfei ^b   Li, Defa ^b   Zhao, Feng Qi ^a  

^a UNIVERSITY OF VERMONT   (United States)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Casein; Oct 1; Transactivator; Transcription factor

Indexed keywords

BETA CASEIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 1; PROLACTIN; STAT5A PROTEIN; STAT5B PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL STRAIN COS7; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENE INTERACTION; GENE LOCATION; GENE MUTATION; HORMONAL REGULATION; LACTATION; MAMMARY GLAND; MOUSE; NONHUMAN; PREGNANCY; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; WILD TYPE;

ANIMALS; CASEINS; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; GLUCOCORTICOIDS; HORMONES; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; OCTAMER TRANSCRIPTION FACTOR-1; PREGNANCY; PROLACTIN; PROMOTER REGIONS, GENETIC; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROLACTIN; RNA, MESSENGER; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

EID: 67650234452     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0078-5     Document Type: Article

References (22)

1. Wyszomierski SL, Yeh J, Rosen JM (1999) Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol 13:330-343. doi: 10.1210/me.13.2.330
2. Wyszomierski SL, Rosen JM (2001) Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/ enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor. Mol Endocrinol 15:228-240. doi: 10.1210/me.15.2.228
3. Liu X, Robinson GW, Gouilleux F et al (1995) Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 92:8831-8835. doi: 10.1073/pnas.92.19.8831
4. Liu X, Robinson GW, Hennighausen L (1996) Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol Endocrinol 10:1496-1506
5. Kazansky AV, Kabotyanski EB, Wyszomierski SL et al (1999) Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A. J Biol Chem 274:22484-22492. doi: 10.1074/ jbc.274.32.22484
6. Teglund S, McKay C, Schuetz E et al (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841-850. doi: 10.1016/S0092-8674(00)81444-0
7. Webster JC, Jewell CM, Bodwell JE et al (1997) Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J Biol Chem 272:9287-9293. doi: 10.1074/jbc.272.13.8236
8. Almlof T, Wright AP, Gustafsson JA (1995) Role of acidic and phosphorylated residues in gene activation by the glucocorticoid receptor. J Biol Chem 270:17535-17540. doi: 10.1074/jbc.270.29.17535
9. Dong B, Zhao F-Q (2007) Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression. Biochem J 401:57-64. doi: 10.1042/BJ20060570
10. Zhao F-Q, Adachi K, Oka T (2002) Involvement of Oct-1 in transcriptional regulation of beta-casein gene expression in mouse mammary gland. Biochim Biophys Acta 1577:27-37
11. Lechner J, Welte T, Tomasi JK et al (1997) Promoter-dependent synergy between glucocorticoid receptor and Stat5 in the activation of beta-casein gene transcription. J Biol Chem 272:20954-20960. doi: 10.1074/jbc.272.33.20954
12. Wang VE, Schmidt T, Chen J et al (2004) Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol 24:1022-1032. doi: 10.1128/ MCB.24.3.1022-1032.2004
13. Kemler I, Schreiber E, Muller MM (1989) Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter. EMBO J 8:2001-2008
14. Zhao F-Q, Zheng Y, Dong B, Oka T (2004) Cloning, genomic organization, expression, and effect on beta-casein promoter activity of a novel isoform of the mouse Oct-1 transcription factor. Gene 326:175-187. doi: 10.1016/j.gene.2003.10.023
15. Imagawa W, Yang J, Guzman R, Nandi S (2000) Collagen gel methods for the primary culture of mouse mammary epithelium. In: Ip MM, Asch BB (eds) Methods in mammary gland biology and breast cancer research. Kluwer Academic/Plenum Publishers, New York, pp 111-123
16. Zhou X, Li D, Yin J et al (2007) CLA differently regulates adipogenesis in stromal vascular cells from porcine subcutaneous adipose and skeletal muscle. J Lipid Res 48:1701-1709. doi: 10.1194/jlr.M600525-JLR200
17. Saito H, Oka T (1996) Hormonally regulated double- and single-stranded DNA-binding complexes involved in mouse beta-casein gene transcription. J Biol Chem 271:8911-8918. doi: 10.1074/jbc.271.15.8911
18. Roberts SB, Segil N, Heintz N (1991) Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science 253:1022-1026. doi: 10.1126/science.1887216
19. Caelles C, Hennemann H, Karin M (1995) M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Mol Cell Biol 15:6694-6701
20. Belsham DD, Mellon PL (2000) Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/ nitric oxide/cyclic-guanosine 5′-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol 14:212-228. doi: 10.1210/me.14.2.212
21. Schild-Poulter C, Shih A, Tantin D et al (2007) DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage. Oncogene 26:3980-3988. doi: 10.1038/sj.onc.1210165
22. Blind RD, Garabedian MJ (2008) Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J Steroid Biochem Mol Biol 109:150-157. doi: 10.1016/ j.jsbmb.2008.01.002