Polycystic ovary syndrome: A model of combinatorial endocrinology?

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 7, 2009, Pages 2250-2251

  Berga, Sarah L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTAMIDE; POTASSIUM CHANNEL; STEROID;

DRUG MECHANISM; EDITORIAL; ENDOCRINOLOGY; INSULIN RESISTANCE; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 67650230094     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0959     Document Type: Editorial

References (9)

1. Blank SK, McCartney CR, Chhabra S, Helm KD, Eagleson CA, Chang RJ, Marshall JC 2009 Modulation of GnRH pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls: implications for regulation of pubertal maturation. J Clin Endocrinol Metab 94:2360-2366
2. Chhabra S, McCartney CR, Yoo RY, Eagleson CA, Chang RJ, Marshall JC 2005 Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenic adolescent girls. J Clin Endocrinol Metab 90:2810-2815
3. Kalro BN, Loucks TL, Berga SL 2001 Neuromodulation in polycystic ovary syndrome. Obstet Gynecol Clin North Am 28:35-62
4. Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, Marshall JC 2000 Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab 85:4047-4052
5. Huang W, Acosta-Martínez M, Levine JE 2008 Ovarian steroids stimulate adenosine triphosphate-sensitive potassium (KATP) channel subunits gene expression and confer responsiveness of gonadotropin-releasing hormone pulse generator to KATP channel modulation. Endocrinology 149:2423-2432
6. Foecking EM, McDevitt MA, Acosta-Martínez M, Horton TH, Levine JE 2008 Neuroendocrine consequences of androgen excess in female rodents. Horm Behav 53:673-679
7. Zhang C, Bosch MA, Levine JE, Rønnekleiv OK, Kelly MJ 2007 Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J Neurosci 27:10153-10164
8. Williams NI, Berga SL, Cameron JL 2007 Synergism between psychosocial and metabolic stressors: impact on reproductive function in cynomolgus monkeys. Am J Physiol Endocrinol Metab 293:E270-E276
9. Gibbs RB, Mauk R, Nelson D, Johnson DA 2009 Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis. Horm Behav 10.1016/j.yhbeh.2009.03.003