Identification of significant effects from an experimental screening design in the absence of effect sparsity

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 23, 2009, Pages 2252-2261

  Dejaegher, B ^a   Durand, A ^a   Vander Heyden, Y ^a  

^a PHARMACEUTICAL INSTITUTE   (Belgium)

Author keywords

Algorithm of Dong; Effect sparsity; Effects significance; Screening design

Indexed keywords

ALTERNATIVE APPROACH; APPLICATION DATA; BIOANALYSIS; EFFECT SPARSITY; EFFECTS SIGNIFICANCE; ERROR ESTIMATES; ERROR ESTIMATIONS; FALSE NEGATIVES; SCREENING DESIGN;

ALGORITHMS; ERROR ANALYSIS;

DESIGN;

GABAPENTIN; PREGABALIN; VIGABATRIN;

ALGORITHM; ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; FALSE POSITIVE RESULT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; PRIORITY JOURNAL; PROCESS DESIGN; SCREENING; THEORY VALIDATION; VALIDATION PROCESS;

ALGORITHMS; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EVALUATION STUDIES AS TOPIC; GUIDELINES AS TOPIC; HUMANS; RESEARCH DESIGN;

EID: 67650174059     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.10.019     Document Type: Article

References (18)

1. Guidelines prepared within the International Conference on Harmonisation of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH), Validation of Analytical Procedures: Text and Methodology, Q2(R1), 2005, 1-13, http://www.ich.org/ (accessed on July 23th 2008).
2. Vander Heyden Y., and Massart D.L. In: Hendriks M.W.B., de Boer J.H., and Smilde A.K. (Eds). Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products (1996), Elsevier, Amsterdam 79-147
3. Vander Heyden Y., Nijhuis A., Smeyers-Verbeke J., Vandeginste B.G.M., and Massart D.L. J. Pharm. Biomed. Anal. 24 (2001) 723
4. Vander Heyden Y., Perrin C., and Massart D.L. In: Valkó K. (Ed). Handbook of Analytical Separations, Vol. 1, Separation Methods in Drug Synthesis and Purification (2000), Elsevier, Amsterdam 163-212
5. Plackett R.L., and Burman J.P. Biometrika 33 (1946) 303
6. Massart D.L., Vandeginste B.G.M., Buydens L.M.C., de Jong S., Lewi P.J., and Smeyers-Verbeke J. Handbook of Chemometrics and Qualimetrics Part A (1997), Elsevier, Amsterdam pp. 367-369, 659-699
7. Nijhuis A., van der Knaap H.C.M., de Jong S., and Vandeginste B.G.M. Anal. Chim. Acta 391 (1999) 187
8. Lenth R.V. Technometrics 31 (1989) 469
9. Dong F. Stat. Sin. 3 (1993) 209
10. Dejaegher B., Capron X., Smeyers-Verbeke J., and Vander Heyden Y. Anal. Chim. Acta 564 (2006) 184
11. Hund E., Vander Heyden Y., Haustein M., Massart D.L., and Smeyers-Verbeke J. J. Chromatogr. A 874 (2000) 167
12. Nguyen Minh Nguyet A., Tallieu L., Plaizier-Vercammen J., Massart D.L., and Vander Heyden Y. J. Pharm. Biomed. Anal. 32 (2003) 1
13. Vander Heyden Y., Bourgeois A., and Massart D.L. Anal. Chim. Acta 347 (1997) 369
14. Perrin C., Fabre H., Maftouh M., Massart D.L., and Vander Heyden Y. J. Chromatogr. A 1007 (2003) 165
15. Vander Heyden Y., Hartmann C., Massart D.L., Michel L., Kiechle P., and Erni F. Anal. Chim. Acta 316 (1995) 15
16. Vannecke C., Bloomfield M.S., Vander Heyden Y., and Massart D.L. Anal. Chim. Acta 455 (2002) 117
17. Vannecke C., Nguyen Minh Nguyet A., Bloomfield M.S., Staple A.J., Vander Heyden Y., and Massart D.L. J. Pharm. Biomed. Anal. 23 (2000) 291
18. Vermeij T.A.C., and Edelbroek P.M. J. Chromatogr. B 810 (2004) 297