Development and validation of a liquid chromatography-atmospheric pressure photoionization-mass spectrometry method for the quantification of alprazolam, flunitrazepam, and their main metabolites in haemolysed blood

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 23, 2009, Pages 2275-2283

  Marchi, Ivano ^a   Schappler, Julie ^a   Veuthey, Jean Luc ^a   Rudaz, Serge ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Alprazolam; APPI; Benzodiazepines; Flunitrazepam; Haemolysed blood; LC APPI MS; SPE; Validation

Indexed keywords

ALPRAZOLAM; APPI; BENZODIAZEPINES; FLUNITRAZEPAM; HAEMOLYSED BLOOD; LC-APPI-MS; SPE; VALIDATION;

ATMOSPHERIC PRESSURE; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; DEUTERIUM; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC POLYMERS; SOLAR RADIATION;

BLOOD;

7 AMINOFLUNITRAZEPAM; ALPHA HYDROXYALPRAZOLAM; ALPRAZOLAM; CLONAZEPAM; DRUG METABOLITE; FLUNITRAZEPAM; LORAZEPAM; NITRAZEPAM; OXAZEPAM; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; DRUG STRUCTURE; HEMOLYSIS; HYDROPHOBICITY; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ALPRAZOLAM; ANTI-ANXIETY AGENTS; CHROMATOGRAPHY, LIQUID; FLUNITRAZEPAM; HUMANS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 67650170363     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.12.002     Document Type: Article

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