Cervical ripening and insufficiency: From biochemical and molecular studies to in vivo clinical examination

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 144, Issue SUPPL 1, 2009, Pages

  Schlembach, Dietmar ^a,b   Mackay, Lynette ^b   Shi, Leili ^b,c   Maner, William L ^b,c   Garfield, Robert E ^b,c   Maul, Holger ^b,d  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b University of Texas Medical Branch School of Medicine   (United States)

^c ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cervical collagen; Cervical insufficiency; Cervical ripening; Light induced fluorescence; Preterm labor

Indexed keywords

COLLAGEN TYPE 1; PROSTAGLANDIN;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; FEMALE; FLUORESCENCE; GYNECOLOGICAL EXAMINATION; HUMAN; INSTRUMENTATION; PHYSIOLOGY; PREGNANCY; PREMATURITY; SPECTROFLUOROMETRY; UTERINE CERVIX; UTERINE CERVIX INCOMPETENCE; UTERINE CERVIX RIPENING;

ANIMALS; CERVICAL RIPENING; CERVIX UTERI; COLLAGEN TYPE I; DIAGNOSTIC TECHNIQUES, OBSTETRICAL AND GYNECOLOGICAL; FEMALE; FLUORESCENCE; HUMANS; PREGNANCY; PREMATURE BIRTH; PROSTAGLANDINS; SPECTROMETRY, FLUORESCENCE; UTERINE CERVICAL INCOMPETENCE;

EID: 67650139460     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2009.02.036     Document Type: Article

References (83)

1. Garfield RE, Saade G, Buhimschi C, et al. Control and assessment of the uterus and cervix during pregnancy and labour. Hum Reprod Update 1998;4:673-95.
2. Garfield RE, Maul H, Shi L, et al. Methods and devices for the management of term and preterm labor. Ann N Y Acad Sci 2001;943:203-24.
3. Hassan SS, Romero R, Maymon E, et al. Does cervical cerclage prevent preterm delivery in patientwith a short cervix? AmJ Obstet Gynecol 2001;184:1325-31.
4. Novy MJ, Gupta A, Wothe DD, Gupta S, Kennedy KA, Gravett MG. Cervical cerclage in the second trimester of pregnancy: a historical cohort study. Am J Obstet Gynecol 2001;184:1447-56.
5. National Center for Health Statistics, www.marchofdimes.com/peristats.
6. Woessner JF, Brewer TH. Formation and breakdown of collagen and elastin in the human uterus during pregnancy and postpartum involution. Biochem J 1963;89:75-82.
7. Leppert PC, Keller S, Cerreta J, Mandl I. Conclusive evidence for the presence of elastin in human and monkey cervix. Am J Obstet Gynecol 1982;142:179-82.
8. Danforth DN. The morphology of the human cervix. Clin Obstet Gynecol 1983;26:7-13.
9. Leppert PC. Anatomy and physiology of cervical ripening. Clinical Obstet Gynecol 1995;38:267-79.
10. Leppert PC. The biochemistry and physiology of the uterine cervix during gestation and parturition. Prenat Neonat Med 1998;3:103-5.
11. Maul H, MacKay L, Garfield RE. Cervical ripening: biochemical, molecular, and clinical considerations. Clin Obstet Gynecol 2006;49:551-63.
12. Harkness ML, Harkness RD. Changes in the physical properties of the uterine cervix of the rat during pregnancy. J Physiol 1959;148:524-47.
13. Bryant WM, Greenwell JE, Weeks PM. Alterations in collagen organization during dilatation of the cervix uteri. Surg Gynecol Obstet 1968;126:27-39.
14. Calder AA, Embrey MP, Tait T. Ripening of the cervix with extra-amniotic prostaglandin E2 in viscous gel before induction of labour. Br J Obstet Gynaecol 1977;84:264-8.
15. Liggins GC. Cervical ripening as an inflammatory reaction. In: Ellwood DA, Anderson ABM, editors. Cervix in pregnancy and labour: clinical and biochemical investigation.. New York: Churchill Livingstone; 1981. p. 1-9.
16. Danforth DN, Veis A, Breen M, Weinstein HG, Buckingham JC, Manalo P. The effect of pregnancy and labor on the human cervix: changes in collagen, glycoproteins, and glycosaminoglycans.AmJObstetGynecol 1986;120:641-51.
17. Rajabi MR, Dean DD, Beydoun SN, Woessner Jr JF. Elevated tissue levels of collagenase during dilation of uterine cervix in human parturition. AmJ Obstet Gynecol 1988;139:971-6.
18. Kokenyesi R, Woessner Jr JF. Relationship between dilatation of the rat uterine cervix and a small dermatan sulfate proteoglycan. Biol Reprod 1990;42:87-97.
19. Leppert PC, Yeh Yu S. Elastin and collagen in the human uterus and cervix: biochemical andhistologicalcorrelation. In: Leppert PC, Woessner JF, editors.The extracellularmatrix of the uterus, cervix and fetalmembranes: synthesis, degradation and hormonal regulation. New York: Perinatology Press; 1991. p. 59-67.
20. Yeh Yu S, Leppert PC. The collagenous tissues of the cervix during pregnancy and delivery. In: Leppert PC, Woessner JF, editors. The extracellular matrix of the uterus, cervix and fetal membranes: synthesis, degradation and hormonal regulation. New York: Perinatology Press; 1991. p. 68-76.
21. Mori Y, Ito A. Cervical ripening: biochemical regulation. In: Leppert PC, Woessner JF, editors. The extracellular matrix of the uterus, cervix and fetal membranes: synthesis, degradation and hormonal regulation. New York: Perinatology Press; 1991. p. 77-86.
22. Ekman G, Almström H, Granström L, Malmström A, Norman M, Woessner JF. Connective tissue in human cervical ripening. In: Leppert PC, Woessner JF, editors. The extracellular matrix of the uterus, cervix and fetal membranes: synthesis, degradation and hormonal regulation. New York: Perinatology Press; 1991. p. 87-96.
23. Robinson G, Filshie GM, Cust M. Medical dilatation of the human cervix. In: Leppert PC, Woessner JF, editors. The extra-cellular matrix of the uterus, cervix and fetal membranes: synthesis, degradation and hormonal regulation. New York: Perinatology Press; 1991. p. 159-81.
24. Rath W, Osmers R, Adelmann-Grill BC, Stuhlsatz HW, Szevereny M, Kuhn W. Biochemical changes in the human cervical connective tissue after intracervical application of prostaglandin E2. Prostaglandins 1993;45:375-84.
25. Ludmir J, Sehdev HM. Anatomy and physiology of the uterine cervix. Clin Obstet Gynecol 2000;43:433-9.
26. Uldbjerg N, Ekman G, Malmström A, Olsson K, Ulmsten U. Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity. Am J Obstet Gynecol 1983;147:662-6.
27. Uldbjerg N, Malmström A, Ekman G, Ulmsten U. The integrity of cervical collagen during pregnancy and labor. Gynecol Obstet Invest 1985;20:68-73.
28. Ekman G, Malmström A, Uldbjerg N, Ulmsten U. Cervical collagen: an important regulator of cervical function in term labor. Obstet Gynecol 1986;67: 633-6.
29. Iwahashi M, Muragaki Y, Ooshima A, Umesaki N. Decreased type I collagen expression in human uterine cervix during pregnancy. J Clin Endocrinol Metab 2003;88:2231-5.
30. Maul H, Olson G, Fittkow CT, Saade GR, Garfield RE. Cervical light-induced fluorescence in humans decreases throughout gestation and before delivery: preliminary observations. Am J Obstet Gynecol 2003;188:537-41.
31. Junqueira LC, Zugaib M, Montes GS, Toledo OM, Krisztán RM, Shigihara KM. Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation. Am J Obstet Gynecol 1980;138:273-81.
32. Rath W, Winkler M, Kemp B. The importance of extracellular matrix in the induction of preterm delivery. J Perinat Med 1998;26:437-41.
33. Chwalisz K, Garfield RE. Antiprogestins in the induction of labor. Ann N Y Acad Sci 1994;734:387-413.
34. Downing SJ, Sherwood OD. The physiological role of relaxin in the pregnant rat. III. The influence of relaxin on cervical extensibility. Endocrinology 1985; 116:1215-20.
35. Mochizuki M, Maruo T. Effect of dehydroepiandrosterone sulfate on interleukin- 8 receptor during cervical ripening in late pregnancy. Acta Physiol Hung 1985;65:267-74.
36. Mahendroo MS, Cala KM, Russell DW. 5 alpha reduced androgens play a key role in murine parturition. Mol Endocrinol 1996;10:380-92.
37. Mahendroo MS, Porter A, Russell DW, Word RA. The parturition defect in steroid 5a-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol 1999;13:981-92.
38. Sennström MB, Ekman G, Westergren-Thorsson G, et al. Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod 2000;6:375-81.
39. Maul H, Shi L, Marx SG, Garfield RE, Saade GR. Local application of plateletactivating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. Am J Obstet Gynecol 2002;187:829- 33.
40. Shi L, Shi SQ, Saade GR, Chwalisz K, Garfield RE. Studies of cervical ripening in pregnant rats: effects of various treatments. Mol Hum Reprod 2000;6:382-9.
41. Törnblom SA, Maul H, Klimaviciute A, et al. mRNA expression and localization of bNOS, eNOS, and iNOS in human cervix at preterm and term labour. Reprod Biol Endocrinol 2005;3:33.
42. Marx SG, Wentz MJ, Mackay LB, et al. Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix. J Histochem Cytochem 2006;54:623-39.
43. Kniss DA, Iams JD. Regulation of parturition update. Endocrine and paracrine effectors of term and preterm labor. Clin Perinatol 1998;25:819-36.
44. Mowa CN, Papka RE. The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides. J Histochem Cytochem 2004;52:1249-58.
45. Harger JH. Cerclage and cervical insufficiency: an evidence based analysis. Obstet Gynecol 2002;100:1313-27.
46. Leppert PC, Yu SY, Keller S, Cerreta J, Mandl I. Decreased elastic fibers and desmosine content in incompetent cervix. Am J Obstet Gynecol 1987;157: 1134-9.
47. Rechberger T, Uldbjerg N, Oxlund H. Connective tissue changes in the cervix during normal pregnancy and pregnancy complicated by cervical incompetence. Obstet Gynecol 1988;71:563-7.
48. PetersenLK, Uldbjerg N. Cervical collageninnon-pregnantwomenwith previous cervical incompetence. Eur J Obstet Gynecol Reprod Biol 1996;67:41-5.
49. Iams JD, Goldenberg RL, Mercer BM, et al. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The preterm prediction study: can low-risk women destined for spontaneous preterm birth be identified? Am J Obstet Gynecol 2001;184:652-5.
50. Newman RB, Goldenberg RL, Iams JD, et al. National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Preterm prediction study: comparison of the cervical score and Bishop score for prediction of spontaneous preterm delivery. Obstet Gynecol 2008;112:508-15.
51. Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964;24:266-8.
52. Imseis HM, Trout WC, Gabbe SG. The microbiologic effect of digital examination. Am J Obstet Gynecol 1999;180:578-80.
53. Andersen HF, Nugent CE, Wanty SD, Hayashi RH. Prediction of risk for preterm delivery by ultrasonographic measurement of cervical length. Am J Obstet Gynecol 1990;163:859-67.
54. Chung TK, Haines CJ, Kong D, Woo WK, Rogers MS. Transvaginal sonography in the diagnosis and management of cervical incompetence. Gynecol Obstet Invest 1993;36:59-61.
55. Iams JD, Paraskos J, Landon MB, Teteris JN, Johnson FF. Cervical sonography in preterm labor. Obstet Gynecol 1994;84:40-6.
56. Gomez R, Galasso M, Romero R, et al. Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1994;171:956-64.
57. Guzman ER, Houlihan C, Vintzileos A. Sonography and transfundal pressure in the evaluation of the cervix during pregnancy. Obstet Gynecol Surv 1995;50: 395-403.
58. Cook CM, Ellwood DA. A longitudinal study of the cervix in pregnancy using transvaginal ultrasound. Br J Obstet Gynaecol 1996;103:16-8.
59. Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Engl J Med 1996;334:567-72.
60. Krebs-Jimenez J, Neubert AG. The microbiological effects of endovaginal sonographic assessment of cervical length. J Ultrasound Med 2002;21:727-9.
61. Zilianti M, Azuaga A, Calderon F. Monitoriung of the effacement of the uterine cervix by transperineal sonography: a new perspective. J Ultrasound Med 1995;14:719-24.
62. Hassan SS, Romero R, Berry SM, et al. Patients with an ultrasonographic cervical length < or =15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 2000;182:1458-67.
63. Hibbard JU, Tart M, Moawad AH. Cervical length at 16-22weeks' gestation and risk for preterm delivery. Obstet Gynecol 2000;96:972-8.
64. Lockwood CJ, Wein R, Lapinski R, et al. The presence of cervical and vaginal fetal fibronectin predicts preterm delivery in an inner-city obstetric population. Am J Obstet Gynecol 1993;169:798-804.
65. Nageotte MP, Casal D, Senyei AE. Fetal fibronectin in patients at increased risk for premature birth. Am J Obstet Gynecol 1994;170:20-5.
66. Lockwood CJ, Moscarelli RD, Wein R, Lynch L, Lapinski RH, Ghidini A. Low concentrations of vaginal fetal fibronectin as a predictor of deliveries occurring after 41 weeks. Am J Obstet Gynecol 1994;171:1-4.
67. Hellemans P, Gerris J, Verdonk P. Fetal fibronectin detection for prediction of preterm birth in low risk women. Br J Obstet Gynaecol 1995;102:207-12.
68. Iams JD, Casal D, McGregor JA, et al. Fetal fibronectin improves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995;173:141-5.
69. Goldenberg RL, Mercer BM, Iams JD, et al. The preterm prediction study: patterns of cervicovaginal fetal fibronectin as predictors of spontaneous preterm delivery. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet gynecol 1997;177:8-12.
70. McGregor JA, Jackson GM, Lachelin GC, et al. Salivary estriol as risk assessment for preterm labor: a prospective trial.AmJ Obstet Gynecol 1995;173:1337-42.
71. Avis NJ, Lindow SW, Kleinermann F. In vitro multifrequency electrical impedance measurements and modeling of the cervix in late pregnancy. Physiol Meas 1996;17(Suppl. 4A):A97-103.
72. Predanic M. Evaluation of a device for objective determination of cervical consistency: a pilot study of device's validity on uterine specimens obtained by total hysterectomy for benign uterine disease. J PerinatMed 2002;30:364-6.
73. O'Connell MP, Tidy J, Wisher SJ, Avis NJ, Brown BH, Lindow SW. An in vivo comparative study of the pregnant and nonpregnant cervix using electrical impedance measurements. BJOG 2000;107:1040-1.
74. Vuskovic V. Device for in vivo measurement of mechanical properties of internal human soft tissues. Technische Wissenschaften ETH. Zürich No. 14222.
75. Bauer M, Mazza E, Nava A, et al. In vivo characterization of the mechanics of human uterine cervices. Ann N Y Acad Sci 2007;1101:186-202.
76. Undenfriend S. Fluorescence Assay in Biology and Medicine, vol. I. New York: Academic Press; 1962.
77. Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards- Kortum R. Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN). Gynecol Oncol 1994;52:31-8.
78. Glassman W, Byam-Smith M, Garfield RE. Changes in rat cervical collagen during gestation and after antiprogesterone treatment as measured in vivo with light-induced autofluorescence. Am J Obstet Gynecol 1995;173:1550-6.
79. Shi L, Shi SQ, Saade GR, Chwalisz K, Garfield RE. Changes incervical resistanceand collagen fluorescence during gestation in rats. J Perinat Med 1999;27:188-94.
80. Maul H, Saade G, Garfield RE. Prediction of term and preterm parturition and treatment monitoring by measurement of cervical cross-linked collagen using light-induced fluorescence. Acta Obstet Gynecol Scand 2005;84:534-6.
81. Fittkow CT, Maul H, Olson G, et al. Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term. Eur J Obstet Gynecol Reprod Biol 2005;123:62-6.
82. Schlembach D, Maul H, Fittkow C, Olson G, Saade G, Garfield RE. Cross-linked collagen in the cervix of pregnant women with cervical insufficiency. Am J Obstet Gynecol 2003;189(Suppl. S70).
83. Mackay LB, Shi L, Maul H, Maner WL, Garfield RE. The effect of bilateral pelvic neurectomy on cervical ripening in pregnant rats. J Perinat Med 2009 [Epub ahead of print].