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Volumn 21, Issue 3, 2009, Pages 291-298

The BeSt story: On strategy trials in rheumatoid arthritis

Author keywords

Combination therapy; Result driven treatment; Rheumatoid arthritis; Tight control; Treatment strategy

Indexed keywords

ADALIMUMAB; ATLIZUMAB; CYCLOSPORIN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; HYDROXYCHLOROQUINE; INFLIXIMAB; METHOTREXATE; PLACEBO; PREDNISOLONE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR INHIBITOR; ANTIRHEUMATIC AGENT; BIOLOGICAL PRODUCT; MONOCLONAL ANTIBODY;

EID: 67650129875     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32832a2f1c     Document Type: Review
Times cited : (42)

References (37)
  • 1
    • 33845506003 scopus 로고    scopus 로고
    • Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: A metaanalysis
    • Finckh A, Liang MH, Van Herckenrode CM, De Pablo P. Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: a metaanalysis. Arthritis Rheum 2006;55:864-872.
    • (2006) Arthritis Rheum , vol.55 , pp. 864-872
    • Finckh, A.1    Liang, M.H.2    Van Herckenrode, C.M.3    De Pablo, P.4
  • 2
    • 0035886157 scopus 로고    scopus 로고
    • Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: Comparison of two cohorts who received different treatment strategies
    • Lard LR, Visser H, Speyer I, et al. Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. Am J Med 2001;111:446-451.
    • (2001) Am J Med , vol.111 , pp. 446-451
    • Lard, L.R.1    Visser, H.2    Speyer, I.3
  • 3
    • 0030696346 scopus 로고    scopus 로고
    • Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: A randomized, controlled, double-blind, 52 week clinical trial
    • Haagsma CJ, Van Riel PL, De Jong AJ, van de Putte LB. Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial. Br J Rheumatol 1997;36:1082-1088.
    • (1997) Br J Rheumatol , vol.36 , pp. 1082-1088
    • Haagsma, C.J.1    Van Riel, P.L.2    De Jong, A.J.3    van de Putte, L.B.4
  • 4
    • 38749141455 scopus 로고    scopus 로고
    • Systematic review: Comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis
    • This systematic review gives an overview of the effectiveness and toxicity of different DMARDS, alone and in combination
    • Donahue KE, Gartlehner G, Jonas DE, et al. Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis. Ann Intern Med 2008;148:124-134. This systematic review gives an overview of the effectiveness and toxicity of different DMARDS, alone and in combination.
    • (2008) Ann Intern Med , vol.148 , pp. 124-134
    • Donahue, K.E.1    Gartlehner, G.2    Jonas, D.E.3
  • 5
    • 27744466694 scopus 로고    scopus 로고
    • Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: A two-year randomized trial
    • Svensson B, Boonen A, Albertsson K, et al. Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthritis Rheum 2005;52:3360-3370.
    • (2005) Arthritis Rheum , vol.52 , pp. 3360-3370
    • Svensson, B.1    Boonen, A.2    Albertsson, K.3
  • 6
    • 0030751946 scopus 로고    scopus 로고
    • Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
    • Boers M, Verhoeven AC, Markusse HM, et al. Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet 1997;350:309-318.
    • (1997) Lancet , vol.350 , pp. 309-318
    • Boers, M.1    Verhoeven, A.C.2    Markusse, H.M.3
  • 7
    • 0033535754 scopus 로고    scopus 로고
    • FIN-RACo trial group. Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: A randomised trial
    • Möttönen T, Hannonen P, Leirisalo-Repo M, et al., FIN-RACo trial group. Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. Lancet 1999;353:1568-1573.
    • (1999) Lancet , vol.353 , pp. 1568-1573
    • Möttönen, T.1    Hannonen, P.2    Leirisalo-Repo, M.3
  • 8
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000;343:1586-1593.
    • (2000) N Engl J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 9
    • 8444239359 scopus 로고    scopus 로고
    • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial
    • St Clair EW, Van der Heijde DMFM, Smolen JS, et al. Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum 2004;50:3432-3443.
    • (2004) Arthritis Rheum , vol.50 , pp. 3432-3443
    • St Clair, E.W.1    Van der Heijde, D.M.F.M.2    Smolen, J.S.3
  • 10
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • Breedveld FC, Weisman MH, Kavanaugh AF, et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006;54:26-37.
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3
  • 11
    • 42449088470 scopus 로고    scopus 로고
    • Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis
    • Choy EH, Smith CM, Farewell V, et al. Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis. Ann Rheum Dis 2008;67:656-663.
    • (2008) Ann Rheum Dis , vol.67 , pp. 656-663
    • Choy, E.H.1    Smith, C.M.2    Farewell, V.3
  • 12
    • 35648991026 scopus 로고    scopus 로고
    • Intensive treatment with methotrexate in early rheumatoid arthritis: Aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
    • Verstappen SM, Jacobs JW, Van der Veen MJ, et al. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis 2007;66:1443-1449.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1443-1449
    • Verstappen, S.M.1    Jacobs, J.W.2    Van der Veen, M.J.3
  • 13
    • 48149100741 scopus 로고    scopus 로고
    • Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): A randomised, doubleblind, parallel treatment trial
    • This large RCT in recent-onset RA patients showed the benefit of treatment with the combination MTX and etenercept compared with MTX alone
    • Emery P, Breedveld FC, Hall S, et al. Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, doubleblind, parallel treatment trial. Lancet 2008;372:375-382. This large RCT in recent-onset RA patients showed the benefit of treatment with the combination MTX and etenercept compared with MTX alone.
    • (2008) Lancet , vol.372 , pp. 375-382
    • Emery, P.1    Breedveld, F.C.2    Hall, S.3
  • 14
    • 43949125192 scopus 로고    scopus 로고
    • Triple therapy in early active rheumatoid arthritis: A randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies
    • This RCT compared a step-up combination starting with SSZ with the initial combination of MTX, SSZ and HCQ while aiming at low disease activity
    • Saunders SA, Capell HA, Stirling A, et al. Triple therapy in early active rheumatoid arthritis: a randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies. Arthritis Rheum 2008;58:1310-1317. This RCT compared a step-up combination starting with SSZ with the initial combination of MTX, SSZ and HCQ while aiming at low disease activity.
    • (2008) Arthritis Rheum , vol.58 , pp. 1310-1317
    • Saunders, S.A.1    Capell, H.A.2    Stirling, A.3
  • 15
    • 54349126968 scopus 로고    scopus 로고
    • Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial
    • Van Tuyl LH, Lems WF, Voskuyl AE, et al. Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial. Ann Rheum Dis 2008;67:1574-1577.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1574-1577
    • Van Tuyl, L.H.1    Lems, W.F.2    Voskuyl, A.E.3
  • 16
    • 67651139044 scopus 로고    scopus 로고
    • In patients with early RA who fail initial MTX, the addition of anti-TNF yields better ACR and EULAR responses than the addition of conventional DMARDs: 1-years results of the SWEFOT trial
    • abstract #1003
    • Van Vollenhoven RF, Ernestam S, Geborek P, et al. In patients with early RA who fail initial MTX, the addition of anti-TNF yields better ACR and EULAR responses than the addition of conventional DMARDs: 1-years results of the SWEFOT trial [abstract #1003]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Van Vollenhoven, R.F.1    Ernestam, S.2    Geborek, P.3
  • 17
    • 67651143392 scopus 로고    scopus 로고
    • Evaluation of two strategies (initial methotrexate monotherapy versus its combination with adalimumab) in management of early active rheumatoid arthritis during the first year of evolution: Data from the Guepard trial
    • abstract #1640
    • Soubrier M, Puechal X, Sibilia J, et al. Evaluation of two strategies (initial methotrexate monotherapy versus its combination with adalimumab) in management of early active rheumatoid arthritis during the first year of evolution: data from the Guepard trial [abstract #1640]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Soubrier, M.1    Puechal, X.2    Sibilia, J.3
  • 18
    • 67651138217 scopus 로고    scopus 로고
    • Leirisalo-Repo M, Kautiainen H, Laasonen L, et al. A randomized, double-blind, placebo-controlled study on addition of infliximab to the FIN-RACo DMARD combination therapy for initial six months in patients with early active rheumatoid arthritis. The NEO-RACo study [abstract #OP-0009]. EULAR Annual Scientific Meeting 2008;2008.
    • Leirisalo-Repo M, Kautiainen H, Laasonen L, et al. A randomized, double-blind, placebo-controlled study on addition of infliximab to the FIN-RACo DMARD combination therapy for initial six months in patients with early active rheumatoid arthritis. The NEO-RACo study [abstract #OP-0009]. EULAR Annual Scientific Meeting 2008;2008.
  • 19
    • 67651134372 scopus 로고    scopus 로고
    • Similar results of aggressive and conventional therapy in the first year of the STRategies in Early Arthritis Management (STREAM) study
    • abstract #1641
    • Van Eijk IC, Nielen MMJ, Van der Horst-Bruinsma IE, et al. Similar results of aggressive and conventional therapy in the first year of the STRategies in Early Arthritis Management (STREAM) study [abstract #1641]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Van Eijk, I.C.1    Nielen, M.M.J.2    Van der Horst-Bruinsma, I.E.3
  • 20
    • 45149113632 scopus 로고    scopus 로고
    • Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying antirheumatic drugs in early rheumatoid arthritis: Second-year clinical and radiographic results from the CIMESTRA study
    • Hetland ML, Stengaard-Pedersen K, Junker P, et al. Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying antirheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study. Ann Rheum Dis 2008;67:815-822.
    • (2008) Ann Rheum Dis , vol.67 , pp. 815-822
    • Hetland, M.L.1    Stengaard-Pedersen, K.2    Junker, P.3
  • 21
    • 67449133540 scopus 로고    scopus 로고
    • Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent onset rheumatoid arthritis
    • clinical and radiological results of the BeSt study, doi: 10.1136/ARD.2008.092254. Four-year
    • Van der Kooij SM, Goekoop-Ruiterman YPM, De Vries-Bouwstra JK, et al. Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent onset rheumatoid arthritis. Ann Rheum Dis 2008 doi: 10.1136/ARD.2008.092254. Four-year clinical and radiological results of the BeSt study.
    • Ann Rheum Dis , vol.2008
    • Van der Kooij, S.M.1    Goekoop-Ruiterman, Y.P.M.2    De Vries-Bouwstra, J.K.3
  • 22
    • 37149038223 scopus 로고    scopus 로고
    • Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis
    • Van der Heijde DMFM, Klareskog L, Landewé R, et al. Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis. Arthritis Rheum 2007;56:3928-3939.
    • (2007) Arthritis Rheum , vol.56 , pp. 3928-3939
    • Van der Heijde, D.M.F.M.1    Klareskog, L.2    Landewé, R.3
  • 23
    • 67651119628 scopus 로고    scopus 로고
    • Rantalaiho V, Laasonen L, Kautiainen H, et al. Window of opportunity in early rheumatoid arthritis: combination therapy with FIN-RACo strategy during the first 2 years translates into less joint erosions in 11-years radiographs [abstract #2043]. ACR Annual Scientific Meeting 2008;2008.
    • Rantalaiho V, Laasonen L, Kautiainen H, et al. Window of opportunity in early rheumatoid arthritis: combination therapy with FIN-RACo strategy during the first 2 years translates into less joint erosions in 11-years radiographs [abstract #2043]. ACR Annual Scientific Meeting 2008;2008.
  • 24
    • 67651137005 scopus 로고    scopus 로고
    • Rate of progression of the COBRA trial cohort after 11 years follow up
    • abstract #2000
    • Van Tuyl LHD, Voskuyl AE, Lems WF, et al. Rate of progression of the COBRA trial cohort after 11 years follow up [abstract #2000]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Van Tuyl, L.H.D.1    Voskuyl, A.E.2    Lems, W.F.3
  • 25
    • 0036166382 scopus 로고    scopus 로고
    • COBRA combination therapy in patients with early rheumatoid arthritis: Long-term structural benefits of a brief intervention
    • Landewé RB, Boers M, Verhoeven AC, et al. COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum 2002;46:347-356.
    • (2002) Arthritis Rheum , vol.46 , pp. 347-356
    • Landewé, R.B.1    Boers, M.2    Verhoeven, A.C.3
  • 26
    • 27744514865 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
    • Goekoop-Ruiterman YPM, De Vries-Bouwstra JK, Allaart CF, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 2005;52:3381-3390.
    • (2005) Arthritis Rheum , vol.52 , pp. 3381-3390
    • Goekoop-Ruiterman, Y.P.M.1    De Vries-Bouwstra, J.K.2    Allaart, C.F.3
  • 27
    • 58349103956 scopus 로고    scopus 로고
    • Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis
    • Van der Kooij SM, De Vries-Bouwstra JK, Goekoop-Ruiterman YPM, et al. Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis. Arthritis Rheum 2008;61:4-12.
    • (2008) Arthritis Rheum , vol.61 , pp. 4-12
    • Van der Kooij, S.M.1    De Vries-Bouwstra, J.K.2    Goekoop-Ruiterman, Y.P.M.3
  • 28
    • 67651143391 scopus 로고    scopus 로고
    • Clinical and radiological outcomes in recent onset rheumatoid arthritis after 5 years of DAS-steered treatment in the BeSt-study
    • abstract #1996
    • Klarenbeek NB, Güler-Yüksel M, van der Kooij SM, et al. Clinical and radiological outcomes in recent onset rheumatoid arthritis after 5 years of DAS-steered treatment in the BeSt-study [abstract #1996]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Klarenbeek, N.B.1    Güler-Yüksel, M.2    van der Kooij, S.M.3
  • 29
    • 37349037671 scopus 로고    scopus 로고
    • Daily practice effectiveness of a step-down treatment in comparison with a tight step-up for early rheumatoid arthritis
    • Verschueren P, Esselens G, Westhovens R. Daily practice effectiveness of a step-down treatment in comparison with a tight step-up for early rheumatoid arthritis. Rheumatology (Oxford) 2008;47:59-64.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 59-64
    • Verschueren, P.1    Esselens, G.2    Westhovens, R.3
  • 30
    • 67651127067 scopus 로고    scopus 로고
    • The AMBITION study: Superiority of tociluzumab vs. methotrexate monotherapy in patients with reumatoid arthritis
    • abstract #1210
    • Jones G, Lowenstein M, Calvo A, et al. The AMBITION study: superiority of tociluzumab vs. methotrexate monotherapy in patients with reumatoid arthritis [abstract #1210]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Jones, G.1    Lowenstein, M.2    Calvo, A.3
  • 31
    • 67549115310 scopus 로고    scopus 로고
    • Clinical and radiological efficacy of initial versus delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis
    • subanalysis of the BeSt study showed that initial treatment with MTX and infliximab leads to better disease control than introducing the combination after failure on traditional DMARDs, doi: 10.1136/ARD.2008.093294. This
    • Van der Kooij SM, Le Cessie S, Goekoop-Ruiterman YPM, et al. Clinical and radiological efficacy of initial versus delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis. Ann Rheum Dis 2008 doi: 10.1136/ARD.2008.093294. This subanalysis of the BeSt study showed that initial treatment with MTX and infliximab leads to better disease control than introducing the combination after failure on traditional DMARDs.
    • Ann Rheum Dis , vol.2008
    • Van der Kooij, S.M.1    Le Cessie, S.2    Goekoop-Ruiterman, Y.P.M.3
  • 32
    • 3242677099 scopus 로고    scopus 로고
    • Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): A single-blind randomised controlled trial
    • Grigor C, Capell H, Stirling A, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 2004;364:263-269.
    • (2004) Lancet , vol.364 , pp. 263-269
    • Grigor, C.1    Capell, H.2    Stirling, A.3
  • 33
    • 38749151004 scopus 로고    scopus 로고
    • Probability of continued low disease activity in patients with recent onset rheumatoid arthritis treated according to the disease activity score
    • Van der Kooij SM, Goekoop-Ruiterman YPM, De Vries-Bouwstra JK, et al. Probability of continued low disease activity in patients with recent onset rheumatoid arthritis treated according to the disease activity score. Ann Rheum Dis 2008;67:266-269.
    • (2008) Ann Rheum Dis , vol.67 , pp. 266-269
    • Van der Kooij, S.M.1    Goekoop-Ruiterman, Y.P.M.2    De Vries-Bouwstra, J.K.3
  • 34
    • 73449106459 scopus 로고    scopus 로고
    • DASdriven therapy versus routine care in patients with recent-onset active rheumatoid arthritis
    • doi: 10.1136/ARD.2008.097683
    • Goekoop-RuitermanYPM, De Vries-Bouwstra JK, Kerstens PJSM, et al. DASdriven therapy versus routine care in patients with recent-onset active rheumatoid arthritis. Ann Rheum Dis 2009 doi: 10.1136/ARD.2008.097683.
    • Ann Rheum Dis , vol.2009
    • Goekoop-RuitermanYPM, D.1    Vries-Bouwstra, J.K.2    Kerstens, P.J.S.M.3
  • 35
    • 67651142140 scopus 로고    scopus 로고
    • Improved outcomes of drug-free remission with DAS-steered therapy compared to conventional therapy for rheumatoid arthritis
    • abstract #2046
    • Van der Woude D, Visser K, Brand R, et al. Improved outcomes of drug-free remission with DAS-steered therapy compared to conventional therapy for rheumatoid arthritis [abstract #2046]. ACR Annual Scientific Meeting 2008;2008.
    • (2008) ACR Annual Scientific Meeting
    • Van der Woude, D.1    Visser, K.2    Brand, R.3
  • 36
    • 67651134371 scopus 로고    scopus 로고
    • Remission can be achieved in 50% of early rheumatoid arthritis patients after 25 weeks in daily clinical practice
    • abstract #OP-0003
    • Kuper I, Hoekstra M, Ten Klooster P, et al. Remission can be achieved in 50% of early rheumatoid arthritis patients after 25 weeks in daily clinical practice [abstract #OP-0003]. EULAR Annual Congress 2008;2008.
    • (2008) EULAR Annual Congress
    • Kuper, I.1    Hoekstra, M.2    Ten Klooster, P.3
  • 37
    • 34347225097 scopus 로고    scopus 로고
    • Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
    • Van Tuyl LH, Plass AM, Lems WF, et al. Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis? Ann Rheum Dis 2007;66:974-976.
    • (2007) Ann Rheum Dis , vol.66 , pp. 974-976
    • Van Tuyl, L.H.1    Plass, A.M.2    Lems, W.F.3


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