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Lovell DJ, Ruperto N, Goodman S, et al. Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med 2008;359: 810-820. This randomized, double-blind, stratified, placebo-controlled, multicenter study evaluated efficacy and safety of adalimumab in juvenile idiopathic arthritis, using a 16-week open-label lead-in phase, 32-week double-blind withdrawal phase, and open-label extension phase. The study was not powered to determine differences between patients using or not using MTX.
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