The yeast GATA factor Gat1 occupies a central position in nitrogen catabolite repression-sensitive gene activation

Molecular and Cellular Biology

Volumn 29, Issue 13, 2009, Pages 3803-3815

  Georis, Isabelle ^a   Feller, André ^a   Vierendeels, Fabienne ^a   Dubois, Evelyne ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Institut de Recherches du CERIA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN; PROTEIN DAL80; PROTEIN GAT1; PROTEIN GLN3; PROTEIN GZF3; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

ARTICLE; CATABOLITE REPRESSION; CONTROLLED STUDY; FUNGAL METABOLISM; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SACCHAROMYCES CEREVISIAE;

GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, FUNGAL; GLUTAMINE; LEUCINE ZIPPERS; NITROGEN; PROLINE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

SACCHAROMYCES CEREVISIAE;

EID: 67650093251     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00399-09     Document Type: Article

References (41)

1. André, B., C. Hein, M. Grenson, and J. C. Jauniaux. 1993. Cloning and expression of the UGA4 gene coding for the inducible GABA-specific transport protein of Saccharomyces cerevisiae. Mol. Gen. Genet. 237:17-25.
2. André, B., D. Talibi, S. Soussi Boudekou, C. Hein, S. Vissers, and D. Coornaert. 1995. Two mutually exclusive regulatory systems inhibit UASGATA, a cluster of 5 -GAT(A/T)A-3′ upstream from the UGA4 gene of Saccharomyces cerevisiae. Nucleic Acids Res. 23:558-564.
3. Beck, T., and M. N. Hall. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-692.
4. Beck, T., A. Schmidt, and M. N. Hall. 1999. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J. Cell Biol. 146:1227-1238.
5. Bertram, P. G., J. H. Choi, J. Carvalho, W. Ai, C. Zeng, T. F. Chan, and X. F. Zheng. 2000. Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. J. Biol. Chem. 275:35727-35733.
6. Cardenas, M. E., N. S. Cutler, M. C. Lorenz, C. J. Di Como, and J. Heitman. 1999. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:3271-3279.
7. Coffman, J. A., R. Rai, T. Cunningham, V. Svetlov, and T. G. Cooper. 1996. Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogencatabolic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:847-858.
8. Coffman, J. A., R. Rai, D. M. Loprete, T. Cunningham, V. Svetlov, and T. G. Cooper. 1997. Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J. Bacteriol. 179:3416-3429.
9. Cooper, T. G. 2002. Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. FEMS Microbiol. Rev. 26:223-238.
10. Courchesne, W. E., and B. Magasanik. 1988. Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes. J. Bacteriol. 170:708-713.
11. Cox, K. H., R. Rai, M. Distler, J. R. Daugherty, J. A. Coffman, and T. G. Cooper. 2000. Saccharomyces cerevisiae GATA sequences function as TATA elements during nitrogen catabolite repression and when Gln3p is excluded from the nucleus by overproduction of Ure2p. J. Biol. Chem. 275:17611- 17618.
12. Cunningham, T. S., R. Andhare, and T. G. Cooper. 2000. Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae. J. Biol. Chem. 275:14408-14414.
13. Cunningham, T. S., and T. G. Cooper. 1991. Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression. Mol. Cell. Biol. 11:6205-6215.
14. Cunningham, T. S., and T. G. Cooper. 1993. The Saccharomyces cerevisiae DAL80 repressor protein binds to multiple copies of GATAA-containing sequences (URSGATA). J. Bacteriol. 175:5851-5861.
15. Cunningham, T. S., R. A. Dorrington, and T. G. Cooper. 1994. The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae. J. Bacteriol. 176:4718-4725.
16. Cunningham, T. S., R. Rai, and T. G. Cooper. 2000. The level of DAL80 expression down-regulates GATA factor-mediated transcription in Saccharomyces cerevisiae. J. Bacteriol. 182:6584-6591.
17. Deberardinis, R. J., J. J. Lum, G. Hatzivassiliou, and C. B. Thompson. 2008. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7:11-20.
18. Feller, A., M. Boeckstaens, A. M. Marini, and E. Dubois. 2006. Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae. J. Biol. Chem. 281:28546-28554.
19. Georis, I., A. Feller, J. J. Tate, T. G. Cooper, and E. Dubois. 2009. NCR-sensitive transcription as a readout of Tor pathway regulation-the genetic background, reporter gene, and GATA-factor assayed determine the outcomes. Genetics 181:861-874.
20. Georis, I., J. J. Tate, T. G. Cooper, and E. Dubois. 2008. Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae. J. Biol. Chem. 283:8919-8929.
21. Haguenauer-Tsapis, R., and B. André. 2004. Membrane trafficking of yeast transporters: mechanisms and physiological control of downregulation. Topics Curr. Genet. 9:273-323.
22. Hardwick, J. S., F. G. Kuruvilla, J. K. Tong, A. F. Shamji, and S. L. Schreiber. 1999. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA 96:14866-14870.
23. Hofman-Bang, J. 1999. Nitrogen catabolite repression in Saccharomyces cerevisiae. Mol. Biotechnol. 12:35-73.
24. Kulkarni, A., T. D. Buford, R. Rai, and T. G. Cooper. 2006. Differing responses of Gat1 and Gln3 phosphorylation and localization to rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae. FEMS Yeast Res. 6:218-229.
25. Longtine, M. S., A. McKenzie III, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953-961.
26. Magasanik, B. 2005. The transduction of the nitrogen regulation signal in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 102:16537-16538.
27. Magasanik, B., and C. A. Kaiser. 2002. Nitrogen regulation in Saccharomyces cerevisiae. Gene 290:1-18.
28. Minehart, P. L., and B. Magasanik. 1991. Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain. Mol. Cell. Biol. 11:6216-6228.
29. Mitchell, A. P., and B. Magasanik. 1984. Regulation of glutamine-repressible gene products by the GLN3 function in Saccharomyces cerevisiae. Mol. Cell. Biol. 4:2758-2766.
30. Rowen, D. W., N. Esiobu, and B. Magasanik. 1997. Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae. J. Bacteriol. 179:3761-3766.
31. Scherens, B., A. Feller, F. Vierendeels, F. Messenguy, and E. Dubois. 2006. Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability at short and long term. FEMS Yeast Res. 6:777-791.
32. Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18:3091-3092.
33. Shewmaker, F., L. Mull, T. Nakayashiki, D. C. Masison, and R. B. Wickner. 2007. Ure2p function is enhanced by its prion domain in Saccharomyces cerevisiae. Genetics 176:1557-1565.
34. Soussi-Boudekou, S., S. Vissers, A. Urrestarazu, J. C. Jauniaux, and B. André. 1997. Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae. Mol. Microbiol. 23:1157-1168.
35. Springael, J. Y., and M. J. Penninckx. 2003. Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Biochem. J. 371:589-595.
36. Stanbrough, M., D. W. Rowen, and B. Magasanik. 1995. Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc. Natl. Acad. Sci. USA 92:9450-9454.
37. Svetlov, V. V., and T. G. Cooper. 1998. The Saccharomyces cerevisiae GATA factors Dal80p and Deh1p can form homo- and heterodimeric complexes. J. Bacteriol. 180:5682-5688.
38. Talibi, D., M. Grenson, and B. André. 1995. Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Nucleic Acids Res. 23:550-557.
39. Tate, J. J., A. Feller, E. Dubois, and T. G. Cooper. 2006. Saccharomyces cerevisiae Sit4 phosphatase is active irrespective of the nitrogen source provided, and Gln3 phosphorylation levels become nitrogen source-responsive in a sit4-deleted strain. J. Biol. Chem. 281:37980-37992.
40. Volland, C., D. Urban-Grimal, G. Geraud, and R. Haguenauer-Tsapis. 1994. Endocytosis and degradation of the yeast uracil permease under adverse conditions. J. Biol. Chem. 269:9833-9841.
41. Wach, A. 1996. PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae. Yeast 12:259-265.