Novel convenient synthesis of rivastigmine

Synthetic Communications

Volumn 39, Issue 9, 2009, Pages 1527-1533

  Hu, Meng ^a   Zhang, Fu Li ^a   Xie, Mei Hua ^a  

^a Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Acetyl cholinesterase inhibitor; Rivastigmine; Synthesis

Indexed keywords

RIVASTIGMINE;

ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 67650090422     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910802531948     Document Type: Article

References (10)

1. Polinsky, R. J. Clinical pharmacology of rivastigmine: A new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin. Therapeutics 1998, 20 (4), 634-647.
2. Enz, A. Phenyl carbamates. GB Patent 2203040, 1987.
3. Abhay, G.; Mangesh, M.; Sanjay, P. R. Novel process for the preparation of aminoalkyl phenyl carbamates. WO2005/061446, 2005.
4. Boeaio, A. A.; Pytkowicz, J.; Cote, A.; Charette, A. B. Asymmetric, catalytic synthesis of α-chiral amines using a novel bis(phosphine) monoxide chiral ligand. J. Am. Chem. Soc. 2003, 125, 14260-14261.
5. Hana, S.; Josef, H.; Stanislav, S. A method of production of (-)-(S)-3- [1-(dimethylamino)ethyl]phenyl-N-methyl-carbamate. WO2004037771, 2004.
6. Ma, D. W.; Pan, Q. B.; Pan, S. Process for preparation of rivastigmine and tartrate. WO2007025481, 2007.
7. Garrido, M.; Vicente, J.; Montserrat, A.; Miquel; Jorge, M. J. Method of obtaining phenyl carbamates. WO2007014973, 2007.
8. Hu, M.; Zhang, F. L.; Xie, M. H. A simple and efficient synthesis of (S)- and (R)-1-(3-methoxyphenyl)ethylamine. Lett. Org. Chem. 2007, 4, 126-128.
9. Bringmann, G.; Geisler, J. P.; Geuder, T.; Kunkel, G.; Kinzinger, L. Enantio- merically pure oxygenated 1-phenylethylamines from substituted acetophe- nones by reductive amination and regiospecific benzylic cleavage. Liebigs. Ann. Chem. 1990, 795-805.
10. Hansen, K. T.; Faarup, P.; Bundgaard, H. Carbamate ester prodrugs of dopaminergic compounds: Synthesis, stability, and bioconversion. J. Pharm. Sci. 1991, 80 (8), 793-798.