Localization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodents

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

Volumn 312, Issue 4, 2009, Pages 375-387

  Bronckers, Antonius L J J ^a,f   Lyaruu, Donacian M ^a   Jansen, Ineke D C ^f   Medina, Juan F ^b   Kellokumpu, Sakari ^c   Hoeben, Kees A ^d   Gawenis, Lara R ^e   Oude Elferink, Ronald P J ^d   Everts, Vincent ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF UTAH   (United States)

^f VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AE2 ANION EXCHANGER; ANION TRANSPORT PROTEIN; ANTIPORTER;

ANIMAL; CONFERENCE PAPER; FACE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAMSTER; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; RAT; SYRIAN HAMSTER; TOOTH; WISTAR RAT;

ANIMALS; ANION TRANSPORT PROTEINS; ANTIPORTERS; CRICETINAE; FACE; IMMUNOHISTOCHEMISTRY; MESOCRICETUS; MICE; RATS; RATS, WISTAR; TOOTH;

CRICETINAE; MUS; RATTUS; RODENTIA;

EID: 67650088018     PISSN: 15525007     EISSN: 15525015     Source Type: Journal    
DOI: 10.1002/jez.b.21267     Document Type: Conference Paper

References (29)

1. Alper SL. 2002. Genetic diseases of acid base transporters. Annu Rev Physiol 64:899-923.
2. Alper SL, Stuart-Tilley AK, Biemesderfeld D, Shmukler BE, Brown D. 1997. Immunolocalization of Ae2 anion exchanger in rat kidney. Am J Physiol 273:F601-F614.
3. Aranda V, Martinez I, Melero S, Lecanda J, Banales JM, Prieto J, Medina JF. 2004. Shared apical sorting of anion exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes. Biochem Biophys Res Commun 319:1040-1046.
4. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K. 2001. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86:4753-4758.
5. Frische S, Zolotarev AS, Kim YH, Praetorius J, Alper S, Nielsen S, Wall SM. 2004. Ae2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol Renal Physiol 286:F1163-F1170.
6. Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H, Takeda S, Takeuchi Y, Fukumoto S, Kangawa K, Nagata K, Kojima M. 2005. Ghrelin directly regulates bone formation. J Bone Miner Res 20:790-798.
7. 3 exchanger are achlorhydric. J Biol Chem 279:30532-30539.
8. Golding S, Mobasheri A, Wilkins RJ, Ellory JC. 1997. Molecular identification of anion exchanger isoforms Ae2 in articular chondrocytes. Trans Am Orthop Res Soc 22:10.
9. Helfrich MH. 2003. Osteoclast diseases. Microsc Res Tech 61:514-532.
10. Holappa K, Suokas M, Soininen P, Kellokumpu S. 2001. Identification of the full length Ae2 (Ae2a) isoforms as the Golgi associated anion exchanger in fibroblast. J Histochem Cytochem 49:259-269.
11. Holappa K, Munoz MT, Egea G, Kellokumpu S. 2004. The Ae2 anion exchanger is necessary for the structural integrity of the Golgi apparatus in mammalian cells. FEBS Lett 564:97-103.
12. Kellokumpu S, Neff L, Jamsa-Kellokumpu S, Kopito R, Baron R. 1988. A 115 kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi mem-branes. Science 242:1308-1311.
13. Kurschat CE, Shmukler BE, Jiang L, Wilhelm S, Kim EH, Chernova MN, Kinne RK, Stewart AK, Alper SL. 2006. Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain. J Biol Chem 281: 1885-1896.
14. Lecanda J, Urtasun R, Medina JF. 2000. Molecular cloning and genomic organization of the mouse AE2 anion exchan-ger gene. Biochem Biophys Res Commun 276:117-124.
15. +-ATPase and carbonic anhydrase II in ameloblasts at maturation. Calcif Tissue Int 55:38-45.
16. Lyaruu DM, Bronckers AL, Mulder L, Mardones P, Medina JF, Kellokumpu S, Oude Elferink RP, Everts V. 2008. The anion exchanger Ae2 is required for enamel maturation in mouse teeth. Matrix Biol 27:119-127.
17. Medina JF, Lecanda J, Acín A, Ciesielczyk P, Prieto J. 2000. Tissue-specific N-terminal isoforms from overlapping alter-nate promoters of the human AE2 anion exchanger gene. Biochem Biophys Res Commun 267:228-235.
18. Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhof R, Bosma PJ, Bakker CT, Elferink RP. 2003. Anion exchanger 2 is essential for spermiogenesis in mice. Proc Natl Acad Sci USA 100:15847-15852.
19. Mobasheri A, Goldring S, Pagakis SN, Corkey K, Pockock AE, Fermor B, O'Brien MJ, Wilkins RJ, Ellory JC, Francis MJO. 1998. Expression of cation exchanger NHE and anion exchanger Ae isoforms in primary human bone derived osteoblasts. Cell Biol Int 22:551-562.
20. Paine ML, Snead ML, Wang HJ, Abuladze N, Pushkin A, Liu W, Kao LY, Wall SM, Kim YH, Kurtz I. 2008. Role of NBCe1 and Ae2 in secretory ameloblasts. J Dent Res 87:391-395.
21. 3 exchanger Ae2 in rat thick ascending limb of Henle's loop in response to changes in acid base and sodium balance. J Am Soc Nephrol 15:2988-2997.
22. a, b mice. Am J Pathol 169:165-176.
23. Rossmann H, Alper SL, Nader M, Wang Z, Gregor M, Seidler U. 2000. Three 5'-variant mRNAs of anion exchanger Ae2 in stomach, and intestine of mouse, rabbit and rat. Epithelial transport and barrier function. Ann N Y Acad Sci 915:81-91.
24. Simmer JP, Fincham AG. 1995. Molecular mechanism of dental enamel formation. Crit Rev Oral Biol Med 6:84-108.
25. Smith CE. 1998. Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med 9:128-161.
26. Smith CE, Nanci A, Denbesten PK. 1993. Effects of chronic fluoride exposure on morphometric parameters defining the stages of amelogenesis and ameloblast modulation in rat incisors. Anat Rec 237:243-258.
27. Smith CE, Chong DL, Bartlett JD, Margolis HC. 2005. Mineral acquisition rates in developing enamel on maxillary and mandibular incisors of rats and mice: implications to extracellular acid loading as apatite crystals mature. J Bone Miner Res 20:240-249.
28. 3 exchangers are encoded by mRNA transcribed from alternative promoters. J Biol Chem 271:7835-7843.
29. Weinmann JP, Schour I. 1945. Experimental studies in calcification. I. The effect of a rachitogenic diet on the dental tissues of the white rat. Am J Pathol 21:821-831.