Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease

Molecular Vision

Volumn 15, Issue , 2009, Pages 1210-1217

  Young, Stephen P ^a   Nessim, Maged ^a   Falciani, Francesco ^a   Trevino, Victor ^a   Banerjee, Somnath P ^a   Scott, Robert A H ^a   Murray, Philip I ^a   Wallace, Graham R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE;

ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISCRIMINANT ANALYSIS; DISEASE CLASSIFICATION; DISEASE MARKER; EYE INFLAMMATION; GENETIC ALGORITHM; HUMAN; IMAGE QUALITY; LENS INDUCED UVEITIS; METABOLITE; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; UVEITIS; VISUAL SYSTEM EXAMINATION; VITREORETINOPATHY; VITREOUS BODY;

BIOLOGICAL MARKERS; CLUSTER ANALYSIS; DIABETIC RETINOPATHY; EYE DISEASES; HUMANS; INFLAMMATION; LEAST-SQUARES ANALYSIS; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRINCIPAL COMPONENT ANALYSIS; SENSITIVITY AND SPECIFICITY; UVEITIS; VITREORETINOPATHY, PROLIFERATIVE; VITREOUS BODY;

EID: 67650080196     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Rosenbaum JT, Deodhar A, Suhler EB, Smith JR. How do you know? Br J Ophthalmol 2004; 88:980-1.
2. Wallace GR, Farmer I, Church A, Graham EM, Stanford MR. Serum levels of chemokines correlate with disease activity in patients with retinal vasculitis. Immunol Lett 2003; 90:59-64.
3. Chen Y, Vaughan RW, Kondeatis E, Fortune F, Graham EM, Stanford MR, Wallace GR. Chemokine gene polymorphisms associate with gender in patients with uveitis. Tissue Antigens 2004; 63:41-5.
4. Wallace GR, Curnow SJ, Wloka K, Salmon M, Murray PI. The role of chemokines and their receptors in ocular disease. Prog Retin Eye Res 2004; 23:435-48.
5. Kotter I, Koch S, Vonthein R, Ruckwaldt U, Amberger M, Gunaydin I, Zierhut M, Stubiger N. Cytokines, cytokine antagonists and soluble adhesion molecules in patients with ocular Behcet's disease treated with human recombinant interferon-alpha2a. Results of an open study and review of the literature. Clin Exp Rheumatol 2005; 23:S20-6.
6. Witmer AN, Vrensen GF, van Noorden CJ, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 2003; 22:1-29.
7. Curnow SJ, Falciani F, Durrani OM, Cheung CM, Ross EJ, Wloka K, Rauz S, Wallace GR, Salmon M, Murray PI. Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Invest Ophthalmol Vis Sci 2005; 46:4251-9.
8. Stanford MR, Vaughan RW, Kondeatis E, Chen Y, Edelsten CE, Graham EM, Wallace GR. Are cytokine gene polymorphisms associated with outcome in patients with idiopathic intermediate uveitis in the United Kingdom? Br J Ophthalmol 2005; 89:1013-6.
9. Martin TM, Zhang G, Luo J, Jin L, Doyle TM, Rajska BM, Coffman JE, Smith JR, Becker MD, Mackensen F, Khan MA, Levinson RD, Schumacher HR, Wade NK, Rosenbaum JT, Reveille JD. A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease. Arthritis Rheum 2005; 52:269-74.
10. Griffin JL. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Curr Opin Chem Biol 2003; 7:648-54.
11. Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW, Clarke S, Schofield PM, McKilligin E, Mosedale DE, Grainger DJ. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002; 8:1439-44.
12. Yi LZ, Yuan DL, Che ZH, Liang YZ, Zhou ZG, Gao HY, Wang YM. Plasma fatty acid metabolic profile coupled with uncorrelated linear discriminant analysis to diagnose and biomarker screening of type 2 diabetes and type 2 diabetic coronary heart diseases. Metabolomics 2008; 4:30-8.
13. Holmes E, Loo RL, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De IM, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008; 453:396-400.
14. Ippolito JE, Xu J, Jain S, Moulder K, Mennerick S, Crowley JR, Townsend RR, Gordon JI. An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. Proc Natl Acad Sci USA 2005; 102:9901-6.
15. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009; 457:910-4.
16. Tessem MB, Bathen TF, Cejkova J, Midelfart A. Effect of UV-A and UV-B irradiation on the metabolic profile of aqueous Humor in rabbits analyzed by H-1 NMR spectroscopy. Invest Ophthalmol Vis Sci 2005; 46:776-81.
17. Tessem MB, Bathen TF, Löfgren S, Saether O, Mody V, Meyer L, Dong X, Söderberg PG, Midelfart A. Biological response in various compartments of the rat lens after in vivo exposure to UVR-B analyzed by HR-MAS H-1 NMR spectroscopy. Invest Ophthalmol Vis Sci 2006; 47:5404-11.
18. Ngumah QC, Buchthal SD, Dacheux RF. Longitudinal noninvasive proton NMR spectroscopy measurement of vitreous lactate in a rabbit model of ocular hypertension. Exp Eye Res 2006; 83:390-400.
19. Rucker JC, Biousse V, Mao H, Sandbach J, Constantinidis I, Newman NJ. Detection of lactate in the human vitreous body using proton magnetic resonance spectroscopy. Arch Ophthalmol 2003; 121:909-11.
20. Viant MR. Improved methods for the acquisition and interpretation of NMR metabolomic data. Biochem Biophys Res Commun 2003; 310:943-8.
21. Martens H, Naes T. Multvariate calibration. New York: John Wiley & Sons; 1989.
22. Chauchard F, Cogdill R, Roussel S, Roger JM, Bellon-Maurel V. Application of LS-SVM to non-linear phenomena in NIR spectroscopy: development of a robust and portable sensor for acidity prediction in grapes. Chemom Intell Lab Syst 2004; 71:141-50.
23. Trevino V, Falciani F. GALGO: an R package for multivariate variable selection using genetic algorithms. Bioinformatics 2006; 22:1154-6.
24. Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly MA, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau D, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan GE, MacInnis GD, Weljie AM, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes BD, Vogel HJ, Querengesser L. HMDB: the Human Metabolome Database. Nucleic Acids Res 2007; 35:D521-6.
25. Tang H, Wang Y, Nicholson JK, Lindon JC. Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma. Anal Biochem 2004; 325:260-72.
26. Gelderman MP, Charukamnoetkanok P, Brady JP, Hung L, Zigler JS, Wawrousek EF, Vistica BP, Fortin E, Chan CC, Gery I. A novel inflammatory eye disease induced by lymphocytes from knockout mice sensitized against the deleted ocular antigen. Clin Exp Immunol 2003; 133:177-81.
27. Murray PI, Clay CD, Mappin C, Salmon M. Molecular analysis of resolving immune responses in uveitis. Clin Exp Immunol 1999; 117:455-61.
28. Muhaya M, Calder V, Towler HM, Shaer B, Mclauchlan M, Lightman S. Characterization of T cells and cytokines in the aqueous humour (AH) in patients with Fuchs' heterochromic cyclitis (FHC) and idiopathic anterior uveitis (IAU). Clin Exp Immunol 1998; 111:123-8.
29. Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. Am J Ophthalmol 2004; 138:46-54.
30. de Groot-Mijnes JD. de VL, Rothova A, Schuller M, van Loon AM, Weersink AJ. Rubella virus is associated with fuchs heterochromic iridocyclitis. Am J Ophthalmol 2006; 141:212-4.
31. Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes. Biochem Biophys Res Commun 2000; 275:715-9.
32. Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 2000; 164:6166-73.
33. Kahnert A, Seiler P, Stein M, Bandermann S, Hahnke K, Mollenkopf H, Kaufmann SH. Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. Eur J Immunol 2006; 36:631-47.
34. Bachetti T, Comini L, Francolini G, Bastianon D, Valetti B, Cadei M, Grigolato P, Suzuki H, Finazzi D, Albertini A, Curello S, Ferrari R. Arginase pathway in human endothelial cells in pathophysiological conditions. J Mol Cell Cardiol 2004; 37:515-23.
35. Banerjee S, Savant V, Scott RA, Curnow SJ, Wallace GR, Murray PI. Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders. Invest Ophthalmol Vis Sci 2007; 48:2203-7.