A numerical study on the flow of blood and the transport of LDL in the human aorta: The physiological significance of the helical flow in the aortic arch

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Liu, Xiao ^a   Pu, Fang ^a   Fan, Yubo ^a   Deng, Xiaoyan ^a   Li, Deyu ^a   Li, Shuyu ^a  

^a BEIHANG UNIVERSITY   (China)

Author keywords

Atherosclerosis; Concentration polarization; Helical flow; Low density lipoprotein; Shear stress

Indexed keywords

LOW DENSITY LIPOPROTEIN;

AORTA ARCH; AORTA FLOW; ARTICLE; ASCENDING AORTA; ATHEROSCLEROSIS; DESCENDING AORTA; HUMAN; LIPID ANALYSIS; PRIORITY JOURNAL; STEADY STATE;

ADULT; ALGORITHMS; AORTA; AORTA, THORACIC; ATHEROSCLEROSIS; HUMANS; LIPOPROTEINS, LDL; MAGNETIC RESONANCE IMAGING; MALE; MODELS, ANATOMIC; MODELS, STATISTICAL; MYOCARDIUM; REGIONAL BLOOD FLOW; SHEAR STRENGTH;

EID: 67650079882     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00266.2009     Document Type: Article

References (41)

1. Berceli SA, Warty VS, Sheppeck RA, Mandarino WA, Tanksale SK, Borovetz HS. Hemodynamics and low density lipoprotein metabolism. Rates of low density lipoprotein incorporation and degradation along medial and lateral walls of the rabbit aorto-iliac bifurcation. Arteriosclerosis 10: 686-694, 1990.
2. Bogren HG, Buonocore MH. 4D magnetic resonance velocity mapping of blood flow patterns in the aorta in young vs. elderly normal subjects. J Magn Reson Imaging 10: 861-869, 1999.
3. Bogren HG, Buonocore MH. Blood flow measurements in the aorta and major arteries with MR velocity mapping. J Magn Reson Imaging 4: 119-130, 1994.
4. Caro CG, Cheshire NJ, Watkins N. Preliminary comparative study of small amplitude helical and conventional ePTFE arteriovenous shunts in pigs. J R Soc Interface 2: 261-266, 2005.
5. Caro CG, Doorly DJ, Tarnawski M, Scott KT, Long Q, Dumoulin CL. Non-planar curvature and branching of arteries and non-planar-type flow. Proc R Soc Lond A 452: 185-197, 1996.
6. Caro CG, Fitz-Gerald JM, Schroter RC. Atheroma and arterial wall shear. Observation, correlation, and proposal for a shear dependent mass transfer mechanism for atherogenesis. Proc R Soc Lond B Biol Sci 117: 109-159, 1971.
7. Chandran KB. Flow dynamics in the human aorta. J Biomech Eng 115: 611-616, 1993.
8. Choi US, Talbot L, Cornet I. Experimental study of wall shear rates in the entry region of a curved tube. J Fluid Mech 93: 465-489, 1979.
9. Deng XY, Marois Y, How T, Merhi Y, King M, Guidoin R, Karino T. Luminal surface concentration of lipoprotein (LDL) and its effect on the wall uptake of cholesterol by canine carotid arteries. J Vasc Surg 21: 135-145, 1995.
10. Fan YB, Xu ZP, Jiang WT, Deng XY, Wan K, Sun AQ. S-type bypass can improve the hemodynamics in the bypassed arteries and suppress intimal hyperplasia along the host artery floor. J Biomech 41: 2498-2505, 2008.
11. Frazin LJ, Vonesh MJ, Chandran KB, Shipkowitz T, Yaacoub AS, McPherson DD. Confirmation and initial documentation of thoracic and abdominal aortic helical flow. An ultrasound study. ASAIO J 42: 951-956, 1996.
12. Friedman MH. Geometric risk factors for arteriosclerosis. Arteriosclerosis 4: 85-94, 1983.
13. Friedman MH, Bargeron CB, Duncan DD, Hutchins GM, Mark FF. Effects of arterial compliance and non-Newtonian rheology on correlations between intimal thickness and wall shear. J Biomech Eng 114: 317-320, 1992.
14. Fung YC. Biomechanics: Circulation (2nd ed.). New York: Springer, 1997, p. 108-108.
15. Gould SE. Pathology of the Heart and Blood Vessels. Springfield, IL: Charles & Thomas, 1968, p. 953-960.
16. Hope TA, Markl M, Wigström L, Alley MT, Miller DC, Herfkens RJ. Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping. J Magn Reson Imaging 26: 1471-1479, 2007.
17. Houston JG, Gandy SJ, Sheppard DG, Dick JB, Belch JJ, Stonebridge PA. Two-dimensional flow quantitative MRI of aortic arch blood flow patterns: effect of age, sex, and presence of carotid atheromatous disease on prevalence of spiral blood flow. J Magn Reson Imaging 18: 169-174, 2003.
18. Hyun S, Kleinstreuer C, Archie JP Jr. Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy. Comput Biol Med 31: 365-384, 2001.
19. Jin S, Oshinski J, Giddens DP. Effects of wall motion and compliance on flow patterns in the ascending aorta. J Biomech Eng 125: 347-354, 2003.
20. Karino T, Asakura T, Mabuchi S. Role of hemodynamic factors in atherogenesis. Adv Exp Med Biol 242: 51-57, 1988.
21. Karino T, Goldsmith HL, Motomiya M, Mabuchi S, Sohara Y. Flow patterns in vessels of simple and complex geometries. Ann NY Acad Sci 516: 422-441, 1987.
22. Kilner PJ, Yang GZ, Mohiaddin RH, Firmin DN, Longmore DB. Helical and retrograde secondary flow patterns in the aortic arch studied by three-directional magnetic resonance velocity mapping. Circulation 88: 2235-2247, 1993.
23. Kleinstreuer C, Hyun S, Buchanan JR Jr, Longest PW, Archie JP Jr, Truskey GA. Hemodynamic parameters and early intimal thickening in branching blood vessels. Crit Rev Biomed Eng 29: 1-64, 2001.
24. Ku DN. Blood flow in arteries. Annu Rev Fluid Mech 29: 399-434, 1997.
25. Ku DN, Giddens DP. Pulsatile flow in a model carotid bifurcation. Arteriosclerosis 3: 31-39, 1983.
26. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 282: 2035-2042, 1999.
27. Moore JE Jr, Maiser SE, Ku DN, Boesiger P. Hemodynamics in the abdominal aorta: a comparison of in vitro and in vivo measurements. J Appl Physiol 76: 1520-1527, 1994.
28. Morbiducci U, Ponzini R, Grigioni M, Redaelli A. Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study. J Biomech 40: 519-534, 2007.
29. Nerem RM. Vascular fluid mechanics, the arterial wall, and atherosclerosis. J Biomech Eng 114: 274-282, 1992.
30. Qiao AK, Guo XL, Wu SG, Zeng YJ, Xu XH. Numerical study of nonlinear pulsatile flow in S-shaped curved arteries. Med Eng Phys 26: 545-552, 2004.
31. Rodkiewicz CM. Localization of early atherosclerotic lesions in the aortic arch in the light of fluid flow. J Biomech 8: 149-156, 1975.
32. Sabbah HN, Khaja F, Brymer JF, Hawkins ET, Stein PD. Blood velocity in the right coronary: relation to the distribution of atherosclerotic lesions. Am J Cardiol 53: 1008-1012, 1984.
33. Seed WA, Wood NB. Velocity patterns in the aorta. Cardiovasc Res 5: 319-330, 1971.
34. Segadal L, Matre K. Blood velocity distribution in the human ascending aorta. Circulation 76: 90-100, 1987.
35. Shahcheraghi N, Dwyer HA, Cheer AY, Barakat AI, Rutaganira T. Unsteady and three-dimensional simulation of blood flow in the human aortic arch. J Biomech Eng 124: 378-387, 2002.
36. Stonebridge PA, Hoskins PR, Allan PL, Belch JF. Spiral laminar flow in vivo. Clin Sci (Lond) 91: 17-21, 1996.
37. Uchida Y, Tomaru T, Nakamura F, Furuse A, Fujimori Y, Hasegawa K. Percutaneous coronary angioscopy in patients with ischemic heart disease. Am Heart J 114: 1216-1222, 1987.
38. Wada S, Karino T. Theoretical prediction of low-density lipoproteins concentration at the luminal surface of an artery with a multiple bend. Ann Biomed Eng 30: 778-791, 2002.
39. Wang GX, Deng XY, Guidoin R. Concentration polarization of macromolecules in canine carotid arteries and its implication for the localization of atherogenesis. J Biomech 36: 45-51, 2003.
40. Yashiro K, Shiratori H, Hamada H. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature 450: 285-288, 2007.
41. Zabielski L, Mestel AJ. Helical flow around arterial bends for varying body mass. J Biomech Eng 122: 135-142, 2000.