Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain

Journal of Clinical Microbiology

Volumn 47, Issue 7, 2009, Pages 2033-2039

  Cano, M E ^a   Rodriguez Martinez J M ^b   Aguero J ^a,c   Pascual, A ^b,d   Calvo, J ^a   Garcia Lobo J M ^c   Velasco, C ^b   Francia, M V ^a   Martinez Martinez L ^a,c  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b School of Medicine   (Spain)

^c University School of Medicine   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE AMPC; CIPROFLOXACIN; EXTENDED SPECTRUM BETA LACTAMASE; NALIDIXIC ACID; QUINOLONE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM DETECTION; BACTERIUM ISOLATION; DRUG SENSITIVITY; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENZYME SYNTHESIS; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; NONHUMAN; PHENOTYPIC VARIATION; PLASMID; PRIORITY JOURNAL; SPAIN;

ANTI-BACTERIAL AGENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTIONS; GENES, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; PLASMIDS; POLYMERASE CHAIN REACTION; QUINOLONES; SEQUENCE ANALYSIS, DNA; SPAIN;

ENTEROBACTER; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE;

EID: 67650074208     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.02229-08     Document Type: Article

References (44)

1. Barton, B. M., G. P. Harding, and A. J. Zuccarelli. 1995. A general method for detecting and sizing large plasmids. Anal. Biochem. 226:235-240.
2. Caddick, J. M., M. Lindgren, M. A. Webber, P. Kotilainen, A. Siitonen, A. J. Hakanen, and L. J. V. Piddock. 2008. Mechanisms of resistance in nontyphoidal Salmonella enterica exhibiting a novel quinolone resistance phenotype, abstr. P-1536. Abstr. 18th Eur. Cong. Clin. Microbiol. Infect. Dis., Barcelona, Spain.
3. Cano, M. E., J. Calvo, J. Agüero, J. M. Rodríguez- Martínez, A. Pascual, and L. Martínez-Martínez. 2007. Plasmid-mediated quinolone resistance among enterobacteria with reduced susceptibility or resistant to ciprofloxacin but susceptible to nalidixic acid. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother, Chicago, IL.
4. Cavaco, L. M., H. Hasman, S. Xia, and F. M. Aarestrup. 2009. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob. Agents Chemother. 53:603-608.
5. Chen, Y. T., H. Y. Shu, L. H. Li, T. L. Liao, K. M. Wu, Y. R. Shiau, J. J. Yan, I. J. Su, S. F. Tsai, and T. L. Lauderdale. 2006. Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate. Antimicrob. Agents Chemother. 50:3861-3866.
6. Hakanen, A. J., M. Lindgren, P. Huovinen, J. Jalava, A. Siitonen, and P. Kotilainen. 2005. New quinolone resistance phenomenon in Salmonella enterica: nalidixic acid-susceptible isolates with reduced fluoroquinolone susceptibility. J. Clin. Microbiol. 43:5775-5778.
7. Hata, M., M. Suzuki, Matsumoto, M. Takahashi, K. Sato, S. Ibe, and K. Sakae. 2005. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob. Agents Chemother. 49: 801-803.
8. Hooper, D. C. 2001. Emerging mechanisms of fluoroquinolone resistance. Emerg. Infect. Dis. 7:337-341.
9. Jacoby, G., V. Cattoir, D. Hooper, L. Martínez-Martínez, P. Nordmann, A. Pascual, L. Poirel, and M. Wang. 2008. qnr gene nomenclature. Antimicrob. Agents Chemother. 52:2297-2299.
10. Jacoby, G. A., N. Chow, and K. B. Waites. 2003. Prevalence of plasmid-mediated quinolone resistance. Antimicrob. Agents Chemother. 47:559-562.
11. Jacoby, G. A., K. E. Walsh, D. M. Mills, V. J. Walker, H. Oh, A. Robicsek, and D. C. Hooper. 2006. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 50:1178-1182.
12. Jun, J., Y. Kwak, S. Kim J. Lee, S. Choi, J. Jeong, Y. Kim, and J. Woo. 2005. Prevalence of plasmid-mediated quinolone resistance in clinical isolates of Enterobacter cloacae from Korea, abstr. C2-787. Abstr. 45th Intersci. Conf. Antimicrob. Agents Chemother., Washington, DC.
13. Karisik, E., M. J. Ellington, R. Pike, R. E. Warren, D. M. Livermore, and N. Woodford. 2006. Wide occurrence of the fluoroquinolone-modifying acetyltransferase gene aac(6′)-Ib-cr in CTX-M-positive Escherichia coli from the United Kingdom. 2513. Abstr. 45th Intersci. Conf. Antimicrob. Agents Chemother., Washington, DC.
14. Kehrenberg, C., S. Friederichs, A. de Jong, G. B. Michael, and S. Schwarz. 2006. Identification of the plasmid-borne quinolone resistance gene qnrS in Salmonella enterica serovar Infantis. J. Antimicrob. Chemother. 58:18-22.
15. Kehrenberg, C., K. L. Hopkins, E. J. Threlfall, and S. Schwarz. 2007. Complete nucleotide sequence of a small qnrS1-carrying plasmid from Salmonella enterica subsp. enterica Typhimurium DT193. J. Antimicrob. Chemother. 60:903-905.
16. Lu, X., X. Ma, and R. Yu. 2007. Study of qnrB among Cephalosporin-Resistant Enterobacteriaceae species in West China. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother., Chicago, IL.
17. Machado, E., T. M. Coque, R. Cantón, F. Baquero, J. C. Sousa, L. Peixe, et al. 2006. Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6′)-Ib-cr gene, which encodes an aminoglycoside- and fluoroquinolone-modifying enzyme. Antimicrob. Agents Chemother. 50:3220-3221.
18. Martínez-Martínez, L., M. E. Cano, J. M. Rodríguez-Martínez, J. Calvo, and A. Pascual. 2008. Plasmid-mediated quinolone resistance. Expert. Rev. Anti-Infect. Ther. 6:685-711.
19. Martínez-Martínez, L., A. Pascual, I. García, J. Tran, and G. A. Jacoby. 2003. Interaction of plasmid and host quinolone resistance. J. Antimicrob. Chemother. 51:1037-1039.
20. Martínez-Martínez, L. A. Pascual, and G. A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797-799.
21. Murray, A., H. Mather, J. E. Coia, and D. J. Brown. 2008. Plasmid-mediated quinolone resistance in nalidixic-acid-susceptible strains of Salmonella enterica isolated in Scotland. J. Antimicrob. Chemother. 62:1153-1155.
22. Paauw, A, A. C. Fluit, J. Verhoef, and M. A. Leverstein-van Hall. 2006. Enterobacter cloacae outbreak and emergence of quinolone resistance gene in Dutch hospital. Emerg. Infect. Dis. 12:807-812.
23. Park, C. H., A. Robicsek, G. A. Jacoby, D. Sahm, and D. C. Hooper. 2006. Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob. Agents Chemother. 50:3953-3955.
24. Paterson, D. L. 2006. Resistance in gram-negative bacteria: enterobacteriaceae. Am. J. Med. 119(Suppl. 1):S20-S28.
25. Périchon, B., P. Courvalin, and M. Galimand. 2007. Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob. Agents Chemother. 51:2464-2469.
26. Poirel, L., V. Cattoir, A. Soares, C. J. Soussy, and P. Nordmann. 2007. Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. Antimicrob. Agents Chemother. 51:631-637.
27. Poirel, L., C. Leviandier, and P. Nordmann. 2006. Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital. Antimicrob. Agents Chemother. 50:3992-3997.
28. Poirel, L., J. D. Pitout, L. Calvo, J. M. Rodriguez-Martinez, D. Church, and P. Nordmann. 2006. In vivo selection of fluoroquinolone- resistant Escherichia coli isolates expressing plasmid-mediated quinolone resistance and expanded-spectrum beta-lactamase. Antimicrob. Agents Chemother. 50:1525-1527.
29. Robicsek, A., G. A. Jacoby, and D. C. Hooper. 2006. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis. 6:629-640.
30. Robicsek, A., D. F. Sahm, J. Strahilevitz, G. A. Jacoby, and D. C. Hooper. 2005. Broader distribution of plasmid-mediated quinolone resistance in the United States. Antimicrob. Agents Chemother. 49:3001-3003.
31. Robicsek, A., J. Strahilevitz, G. A. Jacoby, M. Macielag, D. Abbanat, C. H. Park, K. Bush, and D. C. Hooper. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12:83-88.
32. Robicsek, A., J. Strahilevitz, D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2006. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob. Agents Chemother. 50:2872-2874.
33. Ruiz, J. 2003. Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. J. Antimicrob. Chemother. 51:1109-1117.
34. Sabaté, M., F. Navarro, E. Miró, S. Campoy, B. Mirelis, J. Barbé, and G. Prats. 2002. Novel complex sul1-type integron in Escherichia coli carrying blaCTX-M-9. Antimicrob. Agents Chemother. 46:2656-2661.
35. Strahilevitz, J., D. Engelstein, A. Adler, V. Temper, A. E. Moses, C. Block, and A. Robicsek. 2007. Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005. Antimicrob. Agents Chemother. 51:3001-3003.
36. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
37. Toleman, M. A., P. M. Bennett, and T. R. Walsh. 2006. ISCR elements: novel gene-capturing systems of the 21st century? Microbiol. Mol. Biol. Rev. 70:296-316.
38. Tran, J. H., G. A. Jacoby, and D. C. Hooper. 2005. Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob. Agents Chemother. 49:118-125.
39. Tran, J. H., and G. A. Jacoby. 2002. Mechanism of plasmid-mediated quinolone resistance. Proc. Natl. Acad. Sci. USA 99:5638-5642.
40. Vila, J., M. A. Marcos, and M. T. Jiménez de Anta. 1996. A comparative study of different PCR-based DNA fingerprinting techniques for typing of the Acinetobacter calcoaceticus-A. baumannii complex. J. Med. Microbiol. 44:482-489.
41. Vila, J., J. Ruiz, P. Goñi, M. A Marcos, and M. T. Jiménez de Anta. 1995. Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 39:1201-1203.
42. Wang, C. X., P. Q. Cai, Y. Guo, Z. M. Huang, and Z. H. Mi. 2006. Emerging plasmid-mediated quinolone resistance associated with the qnrA gene in Enterobacter cloacae clinical isolates in China. J. Hosp. Infect. 63:349-350.
43. Wang, M., D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2004. Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. Antimicrob. Agents Chemother. 48:1295-1299.
44. Wang, M. H., X. Xu, S. Wu, D. Zhu, and M. Wang. 2008. A new plasmid-mediated gene for quinolone resistance, qnrC, abstr. O207. Abstr. 18th Eur. Cong. Clin. Microbiol. Infect. Dis., Barcelona, Spain.