Role of antithrombotic therapy and nonsteroidal anti-inflammatory drug use in bleeding gastroduodenal ulcers

Internal Medicine

Volumn 48, Issue 9, 2009, Pages 631-637

  Shimizu, Shohei ^a   Nakamura, Shinichi ^a   Kishino, Maiko ^a   Konishi, Hiroyuki ^a   Shiratori, Keiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Antithrombotic therapy; Gastrointestinal bleeding; Low dose aspirin; Nonsteroidal anti inflammatory drugs (NSAIDs); Warfarin

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTIULCER AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROTON PUMP INHIBITOR; WARFARIN;

ADULT; AGE DISTRIBUTION; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG EFFICACY; DUODENAL ULCER BLEEDING; ENDOSCOPIC SURGERY; FEMALE; GASTRIC ULCER BLEEDING; GASTRODUODENAL ULCER; GASTROINTESTINAL HEMORRHAGE; HELICOBACTER INFECTION; HEMOSTASIS; HUMAN; INCIDENCE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; SEX DIFFERENCE;

AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FEMALE; FIBRINOLYTIC AGENTS; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PEPTIC ULCER; RETROSPECTIVE STUDIES;

EID: 67650070292     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.1793     Document Type: Article

References (20)

1. Guidelines for management of anticoagulant and antiplatelet therapy in cardiovascular disease. Circ J 68 (Suppl. IV): 2004 (in Japanese).
2. Patrono C, Garcia Rodriguez LA, Landolfi R, et al. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 353: 2373-2383, 2005.
3. Garcia-Rodriguez LA, Hernandez-Diaz S, de Abajo FJ. Association between aspirin and upper gastrointestinal complications: systemic review of epidemiologic studies. Br J Clin Pharmacol 52: 563-571, 2001.
4. Ootani H, Iwakiri R, Shimoda R, et al. Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use in bleeding peptic ulcers in Japan. J Gastroenterol 41: 41-46, 2006.
5. Ishikawa S, Inaba T, Noma Y, et al. A clinical study of Japanese patients with severe bleeding ulcers induced by non-steroidal anti-inflammatory drugs. Gastroenterol Endosc 49: 314-323, 2007 (in Japanese, Abstract in English).
6. Sakamoto C, Sugano K, Ota S, et al. Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan. Eur J Clin Pharmacol 62: 765-772, 2006.
7. Forrest JAN, Finlayson NDC, Sherman DJC. Endoscopy in gastrointestinal bleeding. Lancet 2: 394-397, 1974.
8. Taha AS, Angerson WJ, Knill-Jones RP, et al. Upper gastrointestinal haemorrhage associated with low-dose aspirin and anti-thrombotic drugs-a 6-year analysis and comparison with non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 22: 285-289, 2005.
9. Yeomans ND, Lanas AI, Talley NJ, et al. Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther 22: 795-801, 2005.
10. Niv Y, Battler A, Abuksis G, et al. Endoscopy in asymptomatic minidose aspirin consumers. Dig Dis Sci 50: 78-80, 2005.
11. Serrano P, Lanas A, Arroyo MT, et al. Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular disease. Aliment Pharmacol Ther 16: 1945-1953, 2002.
12. Weisman SM, Graham DY. Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Arch Intern Med 162: 2197-2202, 2002.
13. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Br Med J 321: 1183-1187, 2000.
14. Travis AC, Wasan SK, Saltzman JR. Model to predict rebleeding following endoscopic therapy for non-variceal upper gastrointestinal hemorrhage. J Gastroenterol Hepatol 23:1505-1510, 2008.
15. Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatients therapy. Am J Med 87: 144-152, 1989.
16. Landefeld CS, Rosenblatt MW, Goldman L. Major bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions. Am J Med 87: 153-159, 1989.
17. Sam C, Massaro JM, D'Agostino RB, et al. Warfarin and aspirin use and the predictors of major bleeding complications in atrial fibrillation (the Framingham Heart Study). Am J Cardiol 94: 947-951, 2004.
18. Guidelines for management of gastric ulcer. 2nd edition. Jiho, 2007 (in Japanese).
19. Lanas A, Scheiman J. Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin 23: 163-173, 2007.
20. Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 Expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol 103: 1-18, 2008.