Drug delivery to the skin from sub-micron polymeric particle formulations: Influence of particle size and polymer hydrophobicity

Pharmaceutical Research

Volumn 26, Issue 8, 2009, Pages 1995-2001

  Wu, Xiao ^a,b   Biatry, Bruno ^c   Cazeneuve, Colette ^c   Guy, Richard H ^a  

^a University of Bath   (United Kingdom)

^b University of Kentucky   (United States)

^c L ORÉAL RECHERCHE   (France)

Author keywords

Laser scanning confocal microscopy (LSCM); Skin; Sub micron particles; Tape stripping

Indexed keywords

CAB 551 0 01; CAPA 6100; CELLABURATE; MW 10000; MW 16000; MW 50000; POLYCAPROLACTONE; POLYMER; POLYSTYRENE; UNCLASSIFIED DRUG;

ARTICLE; CONFOCAL MICROSCOPY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; HAIR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LASER MICROSCOPY; LIPOPHILICITY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SKIN; SKIN PERMEABILITY; SKIN SURFACE; STRATUM CORNEUM;

ANIMALS; DRUG DELIVERY SYSTEMS; MICROSCOPY, CONFOCAL; PARTICLE SIZE; PERMEABILITY; PHARMACOKINETICS; POLYMERS; SKIN; SWINE;

EID: 67650069769     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9915-1     Document Type: Article

References (22)

1. S Magdassi 1997 Delivery systems in cosmetics Pharmaceutical Research 123-124 671 679 10.1016/S0927-7757(97)03792-8
2. B Luppi T Cerchiara F Bigucci R Basile V Zecchi 2004 Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of sunscreens J Pharm Pharmacol 56 407 411 10.1211/0022357022926
3. IP Kaur R Agrawal 2007 Nanotechnology: a new paradigm in cosmeceuticals Recent Pat Drug Deliv Formul 1 171 182 10.2174/187221107780831888
4. Shefer A, Shefer S. Controlled delivery system for hair care products. U.S. patent 6,491,902.
5. Soane DS, Linford MR. Nanoscopic hair care products. U.S. patent 6,821,509.
6. Quellet C, Hotz J, Balmer M. Polymeric nanoparticles including olfactive components. U.S. patent 7,205,340.
7. R Alvarez-Roman G Barre RH Guy H Fessi 2001 Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection Eur J Pharm Biopharm 52 191 195 10.1016/S0939-6411(01) 00188-6 (Pubitemid 32755898)
8. Wertz PW, Downing DT. Stratum corneum: biological and biochemical considerations. In: Hadgraft J, Guy RH, editors. Transdermal drug delivery. New York: Marcel Dekker, Inc; 1989. p. 1-22.
9. DT Downing ME Stewart PW Wertz SW Colton W Abraham JS Strauss 1987 Skin lipids: an update J Invest Dermatol 88 2s 6s 10.1111/1523-1747.ep12468850 (Pubitemid 17031716)
10. RO Potts RH Guy 1992 Predicting skin permeability Pharm Res 9 663 669 10.1023/A:1015810312465
11. YV Chernysheva VG Babak NR Kildeeva F Boury JP Benoit N Ubrich P Maincent 2003 Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification - solvent evaporation Mendeleev Commun 13 65 67 10.1070/MC2003v013n02ABEH001690
12. YN Kalia F Pirot RH Guy 1996 Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo Biophys J 71 2692 2700 10.1016/S0006-3495(96) 79460-2 (Pubitemid 26367731)
13. RL Anderson JM Cassidy 1973 Variation in physical dimensions and chemical composition of human stratum corneum J Invest Dermatol 61 30 32 10.1111/1523-1747.ep12674117
14. YN Kalia I Alberti N Sekkat C Curdy A Naik RH Guy 2000 Normalization of stratum corneum barrier function and transepidermal water loss in vivo Pharm Res 17 1148 1150 10.1023/A:1026474200575 (Pubitemid 30822402)
15. YN Kalia I Alberti A Naik RH Guy 2001 Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness Skin Pharmacol Appl Skin Physiol 14 Suppl 1 82 86 10.1159/000056394
16. V Jenning A Gysler M Schafer-Korting SH Gohla 2000 Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin Eur J Pharm Biopharm 49 211 218 10.1016/S0939-6411(99) 00075-2 (Pubitemid 30229868)
17. R Alvarez-Roman A Naik YN Kalia RH Guy H Fessi 2004 Skin penetration and distribution of polymeric nanoparticles J Control Release 99 53 62 10.1016/j.jconrel.2004.06.015
18. DM Shotton 1989 Confocal scanning optical microscopy and its application for biological specimens J Cell Sci 94 175 206 (Pubitemid 19272959)
19. E Christophers 1971 Cellular architecture of the stratum corneum J Invest Dermatol 56 165 169 10.1111/1523-1747.ep12260765
20. JC Mackenzie 1969 Ordered structure of the stratum corneum of mammalian skin Nature 222 881 882 10.1038/222881a0
21. AJ Hoogstraate C Cullander JF Nagelkerke F Spies J Verhoef AHGJ Schrijvers HE Junginger HE Bodde 1996 A novel in-situ model for continuous observation of transient drug concentration gradients across buccal epithelium at the microscopical level J Control Release 39 71 78 10.1016/0168-3659(95) 00140-9 (Pubitemid 26135551)
22. M Laurent G Johannin N Gillbert L Lucas D Cassio PX Petit A Fleury 1994 Power and limits of laser scanning confocal microscopy Biol Cell 80 229 240 10.1016/0248-4900(94) 90046-9 (Pubitemid 24237433)