Effect of esophageal acid exposure on the cortical swallowing network in healthy human subjects

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 297, Issue 1, 2009, Pages

  Kern, Mark ^a   Chai, Krisna ^a   Lawal, Adeyemi ^a   Shaker, Reza ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Acidification; Deglutition; Esophagus; Functional MRI; Subliminal

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ESOPHAGUS; EXPOSURE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEARTBURN; HUMAN; HUMAN EXPERIMENT; INSULA; LEFT HEMISPHERE; MOTOR CORTEX; NEUROIMAGING; NORMAL HUMAN; PERFUSION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SENSORY CORTEX; SIGNAL TRANSDUCTION; STIMULATION; SWALLOWING;

ADULT; BRAIN MAPPING; CEREBRAL CORTEX; DEGLUTITION; ESOPHAGUS; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; HUMANS; HYDROCHLORIC ACID; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURAL PATHWAYS; REFERENCE VALUES; REFLEX; SENSORY RECEPTOR CELLS; STIMULATION, CHEMICAL; SUBLIMINAL STIMULATION; VOLITION; YOUNG ADULT;

EID: 67650066783     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00062.2009     Document Type: Article

References (36)

1. Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev 22:229-244, 1996.
2. Birn RM, Bandettini PA, Cox RW, Shaker R. Event-related fMRI of tasks involving brief motion. Hum Brain Mapp 7: 106-114, 1999.
3. Chai K, Kern M, Kounev V, Shaker R. Subliminal esophageal acid stimulation sensitizes the cortical swallowing network in healthy individuals but not GERD patients (Abstract). Neurogastroenterol Motil 18: 680, 2006.
4. Cox RW. AFNI software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29: 162-173, 1996.
5. Critchley HD, Mathias CJ, Josephs O, O'Doherty J, Zanini S, Dewar BK, Cipolotti L, Shallice T, Dolan RJ. Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain 126: 2139-2152, 2003.
6. Dai TH, Lui JZ, Sahgal V, Brown RW, Yue GH. Relationship between muscle output and functional-MRI brain activation. Exp Brain Res 140: 290-300, 2001.
7. Dettmers C, Fink GR, Lemon RN, Stephan KM, Passingham RE, Silbersweig D, Holmes A, Ridding MC, Brooks DJ, Frackowiak RS. Relation between cerebral activity and force in the motor areas of the human brain. J Neurophysiol 74: 802-808, 1995.
8. Drewes AM, Reddy H, Staahl C, Pedersen J, Funch-Jensen P, Arendt-Nielsen L, Gregersen H. Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid. World J Gastroenterol 11: 4367-4374, 2005.
9. Drewes AM, Pedersen J, Reddy H, Rasmussen K, Funch-Jensen P, Arendt-Nielsen L, Gregersen H. Central sensitization in patients with non-cardiac chest pain: a clinical experimental study. Scand J Gastroenterol 41: 640-649, 2006.
10. Dziewas R, Sörös P, Ishii R, Chau W, Henningsen H, Ringelstein EB, Knecht S, Pantev C. Neuroimaging evidence for cortical involvement in the preparation and in the act of swallowing. Neuroimage 20: 135-144, 2003.
11. Hamdy S, Mikulis DJ, Crawley A, Xue S, Lau H, Henry S, Diamant NE. Cortical activation during human volitional swallowing: an event-related fMRI study. Am J Physiol Gastrointest Liver Physiol 277: G219-G225, 1999.
12. Kern M, Arndorfer RC, Hyde JS, Shaker R. Cerebral cortical representation of external anal sphincter contraction: effect of effort. Am J Physiol Gastrointest Liver Physiol 286: G304-G311, 2004.
13. Kern M, Birn R, Jaradeh S, Jesmanowicz A, Cox R, Hyde J, Shaker R. Swallow-related cerebral cortical activity maps are not specific to deglutition. Am J Physiol Gastrointest Liver Physiol 280: G531-G538, 2001.
14. Kern MK, Birn RM, Jaradeh S, Jesmanowicz A, Cox RW, Hyde JS, Shaker R. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology 115: 1353-1362, 1998.
15. Kern MK, Hofmann C, Hyde J, Shaker R. Characterization of the cerebral cortical representation of heartburn in GERD patients. Am J Physiol Gastrointest Liver Physiol 286: G174-G181, 2004.
16. Kern MK, Jaradeh S, Arndorfer RC, Shaker R. Cerebral cortical representation of reflexive and volitional swallowing in humans. Am J Physiol Gastrointest Liver Physiol 280: G354-G360, 2001.
17. Kern MK, Lawal A, Sanjeevi A, Jesmanowicz A, Shaker R. Esophageal acid stimulation sensitizes the swallow-related insular but not cingulate gyrus neural circuitry. Gastroenterology 128, Suppl 2: A373-A374, 2005.
18. Lawal A, Kern M, Sanjeevi A, Antonik S, Mepani R, Rittmann T, Hussaini S, Hofmann C, Tatro L, Jesmanowicz A, Verber M, Shaker R. Neurocognitive processing of esophageal central-sensitization in the insula and cingulate gyrus. Am J Physiol Gastrointest Liver Physiol 294: G787-G794, 2008.
19. Martin R, Barr A, MacIntosh B, Smith R, Stevens T, Taves D, Gati J, Menon R, Hachinski V. Cerebral cortical processing of swallowing in older adults. Exp Brain Res 176: 12-22, 2007.
20. Martin RE, Goodyear BG, Gati Jus Menon RS. Cerebral cortical representation of automatic and volitional swallowing in humans. J Neurophysiol 85: 938-950, 2001.
21. Martin RE, Macintosh BJ, Smith RC, Barr AM, Stevens TK, Gati JS, Menon RS. Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study. J Neurophysiol 92: 2428-2443, 2004.
22. Medda BK, Sengupta JN, Lang M, Shaker R. Response properties of the brainstem of the cat following intra-esophageal acid-pepsin infusion. Neuroscience 135: 1285-1294, 2005.
23. Mosier KM, Liu WC, Maldjian JA, Shah R, Modi B. Lateralization of cortical function in swallowing: a functional MR imaging study. AJNR Am J Neuroradiol 20: 1520-1526, 1999.
24. Mosier K, Patel R, Liu WC, Kalnin A, Maldjian J, Baredes S. Cortical representation of swallowing in normal adults: functional implications. Laryngoscope 109: 1417-1423, 1999.
25. Paine PA, Hamdy S, Chitnis X, Gregory LJ, Giampietro V, Brammer M, Williams S, Aziz Q. Modulation of activity in swallowing motor cortex following esophageal acidification: a functional magnetic resonance imaging study. Dysphagia 23: 146-154, 2008.
26. Reddy H, Staahl C, Arendt-Nielsen L, Gregersen H, Mohr Drewes A, Funch-Jensen P. Sensory and biomechanical properties of the esophagus in non-erosive reflux disease. Scand J Gastroenterol 42: 432-440, 2007.
27. Saab CY, Willis WD. Nociceptive visceral stimulation modulates the activity of cerebellar Purkinje cells. Exp Brain Res 140: 122-126, 2001.
28. Sami SAK, Rossel P, Dimcevski G, Dremstrup Nielsen K, Funch-Jensen P, Valeriani M, Arendt-Nielsen L, Drewes AM. Cortical changes to experimental sensitization of the human esophagus. Neuroscience 140: 269-279, 2006.
29. Sarkar S, Hobson AR, Furlong PL, Woolf CJ, Thompson DG, Aziz Q. Central neural mechanisms mediating human visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 281: G1196-G1202, 2001.
30. Sarkar S, Hobson AR, Hughes A, Growcott J, Woolf CJ, Thompson DG, Aziz Q. The prostaglandin E2 Receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology 124: 18-25, 2003.
31. Toogood JA, Barr AM, Stevens TK, Gati JS, Menon RS, Martin RE. Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) "Go, No-Go" study. Exp Brain Res 161: 81-90, 2005.
32. Vogt BA, Berger GR, Derbyshire SWG. Structural and functional dichotomy of human midcingulate cortex. Eur J Neurosci 18: 3134-3144, 2003.
33. Vogt BA, Vogt L, Laureys S. Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage 29: 452-466, 2006.
34. Willert RP, Delaney C, Kelly K, Sharma A, Aziz Q, Hobson AR. Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification- evidence of central sensitization. Neurogastroenterol Motil 19: 270-278, 2007.
35. Willert RP, Woolf CJ, Hobson AR, Delaney C, Thompson David G, Aziz Q. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Gastroenterology 126: 683-692, 2004.
36. Yang M, Li ZS, Xu XR, Fang DC, Zou DW, Xu GM, Sun ZX, Tu ZX. Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn. Neurogastroenterol Motil 18: 292-299, 2006.