Role of the sulfonium center in determining the ligand specificity of human S-adenosylmethionine decarboxylase

Biochemistry

Volumn 48, Issue 27, 2009, Pages 6423-6430

  Bale, Shridhar ^a   Brooks, Wesley ^b   Hanes, Jeremiah W ^a   Mahesan, Arnold M ^a   Guida, Wayne C ^b,c   Ealick, Steven E ^a  

^a Department of Obstetrics Gynecology   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOMETDC; AROMATIC SIDE CHAINS; BIOSYNTHETIC PATHWAY; CANCER CHEMOTHERAPY; KEY ENZYMES; LIGAND SPECIFICITY; POLYAMINE; POLYAMINE LEVELS; POSITIVE CHARGES; QUANTUM CHEMICAL CALCULATIONS; S-ADENOSYLMETHIONINE; S-ADENOSYLMETHIONINE DECARBOXYLASE; STOPPED FLOW EXPERIMENTS; STOPPED-FLOW KINETICS; SUBSTRATE BINDING;

AMINES; CHEMOTHERAPY; CRYSTALLOGRAPHY; ENZYMES; POSITIVE IONS; QUANTUM CHEMISTRY;

LIGANDS;

5' DEOXY 5' (N DIMETHYL)AMINO 8 METHYLADENOSINE; 5' DEOXY 5' DIMETHYLTHIOADENOSINE; ADENOSINE DERIVATIVE; ADENOSYLMETHIONINE DECARBOXYLASE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR STABILITY; PRIORITY JOURNAL; QUANTUM CHEMISTRY;

ADENOSYLMETHIONINE DECARBOXYLASE; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LIGANDS; PROTEIN CONFORMATION; QUANTUM THEORY; SUBSTRATE SPECIFICITY; SULFONIUM COMPOUNDS; THERMODYNAMICS;

EID: 67650066464     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900590m     Document Type: Article

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