How do psychiatric drugs work?

BMJ (Online)

Volumn 338, Issue 7710, 2009, Pages 1535-1537

  Moncrieff, Joanna ^a   Cohen, David ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHLORPROMAZINE; CLOZAPINE; DOPAMINE RECEPTOR; LITHIUM; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AFFECTIVE PSYCHOSIS; AGITATION; ARTICLE; CLINICAL PRACTICE; DEPRESSION; DRUG MECHANISM; HUMAN; MANIA; MEDICAL DECISION MAKING; PRIORITY JOURNAL; PSYCHIATRY; SCHIZOPHRENIA; SEDATION;

HUMANS; MENTAL DISORDERS; MODELS, CHEMICAL; PSYCHOTROPIC DRUGS;

EID: 67650064696     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Moncrieff J. The myth of the chemical cure: a critique of psychiatric drug treatment. Basingstoke: Palgrave Macmillan, 2008.
2. Deniker P. Experimental neurological syndromes and the new drug therapies in psychiatry. Compr Psychiatry 1960;1:92-102.
3. Cohen D. A critique of the use of neuroleptic drugs in psychiatry. In: Fisher S, Greenberg RP, eds. From placebo to panacea. New York: John Wiley, 1997:173-228.
4. Healy D. Neuroleptics and psychic indifference: a review. J R Soc Med 1989;82:615-9.
5. Mizrahi R, Bagby RM, Zipursky RB, Kapur S. How antipsychotics work: the patients' perspective. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:859-64.
6. Jacobs D, Cohen D. What is really known about the psychological alterations produced by psychiatric drugs? Int J Risk Safety Med 1999;12:37-47.
7. Wolkowitz OM, Pickar D. Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry 1991;148:714-26.
8. Abse DW, Dahlstrom WG, Tolley AG. Evaluation of tranquilizing drugs in the management of acute mental disturbance. Am J Psychiatry 1960;116:973-80.
9. Moncrieff J, Kirsch I. Efficacy of antidepressants in adults. BMJ 2005 16;331:155-7.
10. Moncrieff J. Lithium: evidence reconsidered. Br J Psychiatry 1997;171:113-9.
11. Johnstone EC, Crow TJ, Frith CD, Owens DG. The Northwick Park "functional" psychosis study: diagnosis and treatment response. Lancet 1988 16;ii:119-25.
12. Prien RF, Caffey EM Jr, Klett CJ. Comparison of lithium carbonate and chlorpromazine in the treatment of mania. Report of the Veterans Administration and National Institute of Mental Health Collaborative Study Group. Arch Gen Psychiatry 1972;26:146-53.
13. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003;160:13-23.
14. Moncrieff J. A critique of the dopamine hypothesis of schizophrenia and psychosis. Harv Rev Psychiatry (in press).
15. Belmaker RH, Agam G. Major depressive disorder. N Engl J Med 2008;358:55-68.
16. Cohen D, Jacobs D. Randomized controlled trials of antidepressants: clinically and scientifically irrelevant. Debates Neurosci 2007;1:44-54.
17. Dumont GJ, de Visser SJ, Cohen AF, van Gerven JM. Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects. Br J Clin Pharmacol 2005;59:495-510.
18. Opbroek A, Delgado PL, Laukes C, McGahuey C, Katsanis J, Moreno FA, et al. Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses? Int J Neuropsychopharmacol 2002;5:147-51.
19. American Psychiatric Association. Mental illness stigmas are receding, but misconceptions remain. Press release, 4 May 2005. http://psych.org/ MainMenu/Newsroom/NewsReleases/2005NewsReleases/05-24apanewsreleaseonpoll- %20final.aspx.
20. Moncrieff J, Cohen D, Mason JP. The subjective experience of taking antipsychotic medication: a content analysis of internet data. Acta Psychiatr Scand 2009 Feb 12 [Epub ahead of print].