Tonabersat for migraine prevention: new life or last gasp?

The Lancet Neurology

Volumn 8, Issue 8, 2009, Pages 693-695

  Dodick, David W ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYSERGIDE; TONABERSAT;

CLINICAL TRIAL; DOSE RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; LETTER; MIGRAINE; MIGRAINE AURA; NONHUMAN; PRIORITY JOURNAL; TREATMENT FAILURE;

BENZAMIDES; BENZOPYRANS; CLINICAL TRIALS, PHASE II AS TOPIC; DRUG ADMINISTRATION SCHEDULE; HUMANS; MIGRAINE DISORDERS;

EID: 67650046242     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70174-7     Document Type: Letter

References (11)

1. Hadjikhani N., Del Rio M.S., Wu O., et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA 98 (2001) 4687-4692
2. Bolay H., Reuter U., Dunn A.K., Huang Z., Boas D.A., and Moskowitz M.A. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8 (2002) 136-142
3. Ayata C., Jin H., Kudo C., Dalkara T., and Moskowitz M.A. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 59 (2006) 652-661
4. Hague A.W., Asghar M.S., Schytz H.W., Christensen K., and Olesen J. Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. Lancet Neurol (2009) 10.1016/S1474-4422(09)70135-8 published online June 30.
5. Smith M.I., Read S.J., Chan W.N., et al. Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453. Cephalalgia 20 (2000) 546-553
6. Durham P.L., Damodoram S., Thalakoti S., Freeman S.E., and Garrett F.G. Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signaling. Headache 48 (2008) S5
7. Schwedt T.J., and Dodick D.W. Advanced neuroimaging in migraine. Lancet Neurol 8 (2009) 560-568
8. Kruit M.C., van Buchem M.A., Hofman P.A., et al. Migraine as a risk factor for subclinical brain lesions. JAMA 291 (2004) 427-434
9. Schmitz N., Admiraal-Behloul F., Arkink E.B., et al. Attack frequency and disease duration as indicators for brain damage in migraine. Headache 48 (2008) 1044-1055
10. MacClellan L.R., Giles W., Cole J., et al. Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke 38 (2007) 2438-2445
11. Kurth T., Schürks M., Logroscino G., and Buring J.E. Migraine frequency and risk of cardiovascular disease in women. Neurology (2009) 10.1212/WNL.0b013e3181ab2c20 published online June 24.