Histologic grading of invasive lobular carcinoma: does use of a 2-tiered nuclear grading system improve interobserver variability?

Annals of Diagnostic Pathology

Volumn 13, Issue 4, 2009, Pages 223-225

  Adams, Amy L ^a   Chhieng, David C ^b   Bell, Walter C ^c   Winokur, Tom ^c   Hameed, Omar ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Breast cancer; Interobserver variability; Lobular carcinoma; Nottingham grade

Indexed keywords

2 TIERED NUCLEAR GRADE; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; INVASIVE CARCINOMA; INVASIVE LOBULAR CARCINOMA; NOTTINGHAM HISTOLOGIC GRADE; OBSERVER VARIATION; PATHOLOGIST; PRIORITY JOURNAL; PROGNOSIS;

BREAST NEOPLASMS; CARCINOMA, LOBULAR; CELL NUCLEUS; FEMALE; HUMANS; NEOPLASM INVASIVENESS; OBSERVER VARIATION; PROGNOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 67650021327     PISSN: 10929134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2009.03.004     Document Type: Article

References (16)

1. Elston C.W., and Ellis I.O. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19 5 (1991) 403-410
2. Pereira H., Pinder S.E., Sibbering D.M., et al. Pathological prognostic factors in breast cancer. IV: should you be a typer or a grader? A comparative study of two histological prognostic features in operable breast carcinoma. Histopathology 27 3 (1995) 219-226
3. Haybittle J.L., Blamey R.W., Elston C.W., et al. A prognostic index in primary breast cancer. Br J Cancer 45 3 (1982) 361-366
4. Balslev I., Axelsson C.K., Zedeler K., Rasmussen B.B., Carstensen B., and Mouridsen H.T. The Nottingham Prognostic Index applied to 9,149 patients from the studies of the Danish Breast Cancer Cooperative Group (DBCG). Breast Cancer Res Treat 32 3 (1994) 281-290
5. D'Eredita G., Giardina C., Martellotta M., Natale T., and Ferrarese F. Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution. Eur J Cancer 37 5 (2001) 591-596
6. Galea M.H., Blamey R.W., Elston C.E., and Ellis I.O. The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Res Treat 22 3 (1992) 207-219
7. Okugawa H., Yamamoto D., Uemura Y., et al. Prognostic factors in breast cancer: the value of the Nottingham Prognostic Index for patients treated in a single institution. Surg Today 35 11 (2005) 907-911
8. Adams AL, Li Y, Pfeifer JD, Hameed O. Nuclear grade and survival in invasive lobular carcinoma: a case series with long-term follow-up. Breast J (In Press).
9. Bloom H.J., and Richardson W.W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11 3 (1957) 359-377
10. Rakha E.A., El-Sayed M.E., Menon S., Green A.R., Lee A.H., and Ellis I.O. Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast. Breast Cancer Res Treat (2007)
11. Sinha P.S., Bendall S., and Bates T. Does routine grading of invasive lobular cancer of the breast have the same prognostic significance as for ductal cancers?. Eur J Surg Oncol 26 8 (2000) 733-737
12. Talman M.L., Jensen M.B., and Rank F. Invasive lobular breast cancer. Prognostic significance of histological malignancy grading. Acta Oncol 46 6 (2007) 803-809
13. Frierson Jr. H.F., Wolber R.A., Berean K.W., et al. Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma. Am J Clin Pathol 103 2 (1995) 195-198
14. Longacre T.A., Ennis M., Quenneville L.A., et al. Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study. Mod Pathol 19 2 (2006) 195-207
15. Meyer J.S., Alvarez C., Milikowski C., et al. Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index. Mod Pathol 18 8 (2005) 1067-1078
16. Sloane J.P., Amendoeira I., Apostolikas N., et al. Consistency achieved by 23 European pathologists from 12 countries in diagnosing breast disease and reporting prognostic features of carcinomas. European Commission Working Group on Breast Screening Pathology. Virchows Arch 434 1 (1999) 3-10