A natural pertactin deficient strain of Bordetella pertussis shows improved entry in human monocyte-derived dendritic cells

New Microbiologica

Volumn 32, Issue 2, 2009, Pages 159-166

  Stefanelli, Paola ^a   Fazio, Cecilia ^a   Fedele, Giorgio ^a   Spensieri, Fabiana ^a   Ausiello, Clara Maria ^a   Mastrantonio, Paola ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Bordetella; Dendritic cells; Pertactin

Indexed keywords

B7 ANTIGEN; BORDETELLA VIRULENCE FACTOR; CD83 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN DERIVATIVE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; PERTACTIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BORDETELLA PERTUSSIS; CULTURE TECHNIQUE; CYTOLOGY; DENDRITIC CELL; HUMAN; IMMUNOLOGY; INFANT; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MONOCYTE; MOUSE; PATHOGENICITY; PERTUSSIS; VIRULENCE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; BACTERIAL OUTER MEMBRANE PROTEINS; BORDETELLA PERTUSSIS; CELL CULTURE TECHNIQUES; DENDRITIC CELLS; HLA-DR ANTIGENS; HUMANS; IMMUNOGLOBULINS; INFANT; INTERLEUKINS; MEMBRANE GLYCOPROTEINS; MICE; MONOCYTES; VIRULENCE; VIRULENCE FACTORS, BORDETELLA; WHOOPING COUGH;

BORDETELLA; BORDETELLA PERTUSSIS; MUS;

EID: 67650004050     PISSN: 11217138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. AUSIELLO CM., FEDELE G., URBANI F., LANDE R., DI CARLO B., CASSONE A. (2002). Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses.J. Infect. Dis. 186, 351-360.
2. AUSIELLO CM., LANDE R., STEFANELLI R, FAZIO C, FEDELE G., PALAZZO R., URBANI E, MASTRANTONIO P. (2003). T-cell response assessment as a complement to serology and intranasal protection assays in determining the protective immunity induced by acel- lular pertussis vaccines in mice. Clinic. Diagn. Lab. Immunol. 10, 637-642.
3. AUSIELLO CM., URBANI F., LA SALA A., LANDE R., PISCITELLI A., CASSONE A. (1997). Acellular vaccines induce cellular-mediated immunity to Bordetella pertussis antigens in infants undergoing primary vaccination against pertussis. Dev. Biol. Stand. 89, 315-320.
4. AUSIELLO CM., LANDE R., URBANI F, LA SALA A., STEFANELLI P., SALMASO S., MASTRANTONIO P., CASSONE A. (1999). Cell-mediated immune responses in four-year-old children after primary immunization witb acellular pertussis vaccines. Infect. Immim. 67, 4064-4071.
5. BASSINET L., GUEIRARD P., MAITRE B., HOUSSET B., GOUNON P., GUISO N. (2000). Role of adhesins and toxins in invasion of human tracheal epithelial cells by Bordetella pertussis. Infect. Immun. 68, 1934- 1941.
6. CASSONE A., AUSIELLO C.M.,URBANI E, ET AL. (1997). Cell- mediated and antibody responses to Bordetella per-tussis antigens in children vaccinated with acellular or whole-cell pertussis vaccines. The Progetto Pertosse-CMI Working Group. Arch. Pediatr. Adolesc. Med. 151, 283-289.
7. CHARLES I.G., LI J.L., ROBERTS M., BEESLEY K., ROMANOS M., PICKARD D.J., FRANCIS M., CAMPBELL D., DOUGAN G., BRENNAN M.J., ET AL. (1991). Identification and characterization of a protective immunodominant B cell epitope of pertactin (P.69) from Bordetella pertussis. Eur. J. Immunol. 21, 1147-1153.
8. FEDELE G., STEFANELLI P., SPENSIERI R, FAZIO C, MASTRANTONIO P., AUSIELLO CM. (2005). Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Thl polarization and interleukin-23 expression. Infect. Immun. 73, 1590-1597.
9. GEUIJEN C.A., WILLEMS R.J., BONGAERTS M., TOP J., GIELEN H., MooI F.R. (1997). Role of the Bordetella pertussis minor fimbrial subunit, FimD, in colonization of the mouse respiratory tract. Infect. Immun. 65, 4222-4228.
10. GODFROID E, DENOËL P., DE GRAVE D., SCHUERMAN L., POOLMAN J. (2004). Diphteria-tetanus- pertussis (DTP) combination vaccines and evaluation of pertussis immune responses. Intern. J. of Medical Microbiol. 294, 269-276.
11. GRECO D., SALMASO S., MASTRANTONIO P., GIULIANO M., TOZZI A.E., ANEMONA, A., CIOFI DEGLI ATTI M.L., GIAMMANCO A., PANEI P., BLACKWELDER W.C., KLEIN D.L., WASSILAK S.G. (1996). A controlled trial of two acellular vaccines and one whole cell vaccine against pertussis. N. Engl. J. Med. 334, 341-348.
12. GUISO N., CAPIAU C, CARLETTI G., POOLMAN J., HAUSER P. (1999). Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines. Vaccine. 14, 2366-2376.
13. HELLWIG S.M., RODRIGUEZ M.E., BERBERS G.A., VAN DE WINKEL J.K., MOOI F.R. (2003). Crucial role of antibodies to pertactin in Bordetella pertussis immunity.J. Infect. Dis. 188, 738-742.
14. ISHIBASHI Y., RELMAN D.A., NISHIKAWA A. (2001). Invasion of human respiratory epithelial cells by Bordetella pertussis: possible role for a filamentous hemagglutinin Arg-Gly-Asp sequence and 51 inte- grin. Microb. Pathog. 30, 279-288.
15. KHELEF N., GUISO N. (1995). Induction of macrophages apoptosis by Bordetella pertussis adenylate cyclase- hemolysin. FEMS Microbiol. Lett. 134, 27-32.
16. LAEMMLI U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227, 680-685.
17. LEININGER E., ROBERTS M., KENIMER EG., CHARLES I.G., FAIRWEATHER N., NOVOTNY P., BRENNAN M.J. (1991). Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc. Natl. Acad. Sci. USA 88, 345-349.
18. LENZ D.H., WEINGART C.L., WEISS A.A. (2000). Phagocytosed Bordetella pertussis fails to survive in human neutrofils. Infect. Immun. 68, 956-959.
19. MACLAFFERTY M.A., HARCUS D.R., HEWLETT E.L. (1988). Nucleotide sequence and characterization of a repetitive DNA element from the genome of Bordetella pertussis with characteristics of an insertion sequence./. Gen. Microbiol. 134, 2297-2306.
20. MASTRANTONIO P., SPIGAGLIA P., VAN OIRSCHOT H., VAN DER HEIDE H.G.J., HEUVELMAN K., STEFANELLI P., Mooi F.R. (1999). Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvacci- nated children. Microbiology. 145, 2069-2075.
21. MCGUIRK P., MCCANN C, MILLS K.H. (2002). Pathogen- specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195, 221-231.
22. MILLS K.H. (2001). Immunity to Bordetella pertussis. Microb. Infect. 3, 655-677.
23. OLIN P., RASMUSSEN E, GUSTAFSSON L., HALLANDER H.O., HEIJBEL H. (1997). Randomised controlled trial of two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Lancet. 350,1569-1577.
24. ROBERTS M., FAIRWEATHER N.F., LEININGER D., ET AL. (1991). Construction and characterization of Bordetella pertussis mutants lacking the vir-regu- lated P.69 outer membrane protein. Mol. Microbiol. 5, 1393-1404.
25. ROBERTS, M., TITE, J.P., FAIRWEATHER, N.F., DOUGAN, G., CHARLES, I.G.(1992). Recombinant P.69/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection. Vaccine. 10, 43-48.
26. ROBERTS M., CROPLEY I., CHATFIELD S., DOUGAN G. (1993). Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA. Vaccine. 11, 866-872.
27. RYAN M., MURPHY G., RYAN E., NILSSON L., SHACKLEY E, GOTHEFORS L., OYMAR K., MILLER E., STORSAETER J., MILLS K.H. (1998). Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children. Immunology. 93, 1-10.
28. SCHAEFFER L.M., WEISS A.A. (2001). Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes. Infect. Immun. 69, 7635-7641.
29. SHUMILLA J.A., LACAILLE V., HORNELL T.M., HUANG J., NARASIMHAN S., RELMAN D.A., MELLINS E.D. (2004). Bordetella pertussis infection of primary human monocytes alters HLA-DR expression. Infect. Immun. 72, 1450-1462.
30. SPENSIERI E, FEDELE G., FAZIO C, NASSO M., STEFANELLI P., MASTRANTONIO P., AUSIELLO CM. (2006). Bordetella pertussis inhibition of interleukin-12 (IL- 12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin- dependent cyclic AMP induction. Infect. Immun. 74, 2831-2838.
31. STEFANELLI P., DE MARZI L., ROBINO. L., ET AL. (1999). Characterization of Bordetella pertussis strains of recent isolation. Microbiologica. 22, 187-194.
32. STEFANELLI P., IPPOLITI R., FAZIO C, MASTRANTONIO P. (2002). Role of immune sera in the in-vitro phagocytosis of Bordetella pertussis strains. Microb. Patog. 32,135-141.
33. STEINMAN R.M., HEMMI H. (2006). Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311, 17-58.
34. TONON S., GORIELY S., AKSOY E., PRADIER O., DEL GIUDICE G., TRANNOY E., WILLEMS F, GOLDMAN M., DE WIT D. (2002). Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. Eur. J. Immunol. 32, 3118-3125.
35. VANDEBRIEL R.J., HELLWIG S.M., VERMEULEN J.R, ET AL. (2003). Association of Bordetella pertussis with host immune cells in the mouse lung. Microb. Pathog. 35, 19-29.
36. VAN DEN BERG, B.M., BEEKHUIZEN, h., WILLEMS, R.J.L., MOOI, F.R., VAN FURTH, R. (1999). Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. Infect. Immun. 67, 1056-1062.
37. WEINGART C.L., WEISS A.A. (2000). Bordetella pertussis virulence factors affect phagocytosis by human neutrophils. Infect. Immun. 68, 1735-1739.