Intravenous immunoglobulin therapy for autoantibody-positive cerebellar ataxia

Internal Medicine

Volumn 48, Issue 10, 2009, Pages 783-790

  Nanri, Kazunori ^a   Okita, Mitsunori ^a   Takeguchi, Masafumi ^a   Taguchi, Takeshi ^a   Ishiko, Tomoko ^a   Saito, Hirohiko ^a   Otsuka, Takao ^a   Mitoma, Hiroshi ^b   Koizumi, Kiyoshi ^a  

^a TOKYO MEDICAL UNIVERSITY HACHIOJI MEDICAL CENTER   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Anti GAD antibody; Anti gliadin antibody; Anti thyroid antibody; Cerebellar ataxia; IVIg; SCA3; SPECT

Indexed keywords

ATAXIN 3; GLIADIN ANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN; PLACEBO;

ADULT; AGED; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; BRAIN ATROPHY; BRAIN BLOOD FLOW; BRAIN PERFUSION; CEREBELLAR ATAXIA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; FEMALE; HUMAN; MALE; OUTCOME ASSESSMENT; SHY DRAGER SYNDROME; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; AUTOANTIBODIES; CEREBELLAR ATAXIA; CYSTEINE; FEMALE; GLIADIN; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IODIDE PEROXIDASE; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 67650002097     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.1802     Document Type: Article

References (36)

1. Birand B, Cabre P, Bonnan M, Olindo S, Smagja D. A new case of cerebellar ataxia with anti-GAD antibodies treated with corticosteroids and initially seronegative. Rev Med Interne 27: 616-619, 2006.
2. Chang CC, Eggers SD, Johnson JK, Haman A, Miller BL, Geschwind MD. Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease. Clin Neurol Neurosurg 109: 54-57, 2007.
3. Sander HW, Magda P, Chin RL, et al. Cerebellar ataxia and coeliac disease. Lancet 362: 1548, 2008.
4. Stangel M, Hartung HP, Marx P, Gold RJ. Intravenous immunoglobulin treatment of neurological autoimmune diseases. J Neurol Sci 153: 203-214, 1998.
5. Dalakas MC. Intravenous immunoglobulin in autoimmune neuromuscular diseases. JAMA 291: 2367-2375, 2004.
6. Abele M, Weller M, Mescheriakov S, Burk K, Dichgans J, Klockgether T. Cerebellar ataxia with glutamic acid decarboxylase autoantibodies. Neurology 52: 857-859, 1999.
7. Ances BM, Dalmau JO, Tsai J, Hasbani MJ, Galetta SL. Down-beating nystagmus and muscle spasms in a patient with glutamicacid decarboxylase antibodies. Am J Ophthalmol 140: 142-144, 2005.
8. Burk K, Melms A, Schulz JB, Dichgans J. Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 50: 827-828, 2001.
9. Lauria G, Pareyson D, Pitzolu MG, Bazzigaluppi E. Excellent response to steroid treatment in anti-GAD cerebellar ataxia. Lancet Neurol 2: 634-635, 2008.
10. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. A quantitative approach to techetium-99m hexamethylpropylene amine oxime. Eur J Nucl Med 19: 195-200, 1992.
11. 99mTc-ECD SPECT. Eur J Nucl Med 29: 331-341, 2002.
12. Dalakas MC, Li M, Fujii M, Jacobowitz DM. Stiff-person syndrome. Quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 57: 780-784, 2001.
13. Vulliemoz S, Vanini G, Truffert A, Chizzolini C, Seeck M. Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies. J Neurol Neurosurg Psychiatry 78: 187-189, 2007.
14. Ishida K, Mitoma H, Wada Y, et al. Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia. J Neurol Neurosurg Psychiatry 78: 190-192, 2007.
15. Hadjivassiliou M, Grunewald R, Sharrack B, et al. Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Brain 126: 685-691, 2003.
16. Selim M, Drachman DA. Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis. J Neurol Neurosurg Psychiatry 71: 81-87, 2001.
17. Nakagawa H, Yoneda M, Fujii A, Kinomoto K, Kuriyama M. Hashimoto's encephalopathy presenting with progressive cerebellar ataxia. J Neurol Neurosurg Psychiatry 78: 196-197, 2007.
18. Shimomura T, Kuno N, Takenaka T, Maeda M, Takahashi K. Purkinje cell antibody in lupus ataxia. Lancet 342: 375-376, 1993.
19. Hitoshi S, Kusunoki S, Chiba A, et al. Cerebellar ataxia and polyneuropathy in a patient with IgM M-protein specific to the Gal (β1-3) GalNAc epitope. J Neurol Sci 126: 219-224, 1994.
20. Collison K, Rees J. A symmetric cerebellar ataxia and limbic encephalitis as a presenting feature of primary Sjögren's syndrome. J Neurol 254: 1609-1611, 2007.
21. Hirose M. A possible variant of neuro-Behçet disease presenting chronic progressive ataxia without mucocutaneo-ocular syndrome. Rheumatol Int 27: 61, 2006.
22. Honnorat J, Saiz A, Giometto B, et al. Cerebellar ataxia with antiglutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol 58: 225-230, 2001.
23. Takenoshita H, Shizuka-Ikeda M, Mitoma H, et al. Presyanaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiatry 70: 386-389, 2001.
24. Manto M, Laute M, Aguera M, Rogemond V, Pandolfo M, Honnorat J. Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol 61: 544-551, 2007.
25. Dalakas MC. The role of IVIg in the treatment of patients with stiff person syndrome and other neurological diseases associated with anti-GAD antibodies. J Neurol 252 Suppl 1: I19-I25, 2005.
26. Ikeda J, Harada T, Kamei H, Nakamura S. Autoantibody to glutamate decarboxylase in a patient with spinocerebellar degeneration and Sjögren syndrome. No To Shinkei 50: 177-180, 1998.
27. Saiz A, Blanco Y, Sabater L, et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131: 2553-2563, 2008.
28. Ihara M, Makino F, Sawada H, et al. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med 45: 135-140, 2006.
29. Leach JP, Chadwick DW, Miles JB, Hart IK. Improvement in adult-onset Rasmussen's encephalitis with long-term immunomodulatory therapy. Neurology 52: 738-742, 1999.
30. Vinjamuri S, Leach JP, Hart IK. Serial perfusion brain tomographic scans detect reversible focal ischaemia in Rasmussen's encephalitis. Postgrad Med J 76: 33-35, 2000.
31. Baron Y, Bargemann T, Harten P, Gutschmidt HJ. Thrombocytopenic thrombotic purpura: severe clinic with no CT, minor MRI, but a SPECT correlate. Eur J Radiol 31: 56-62, 1999.
32. Tsurikisawa N, Kurosaka N, Takeichi Y, et al. A case report of Churg-Strauss syndrome in whom symptoms of dementia improved with IVIG therapy. Peripheral Nerve 17: 74-82, 2006.
33. Jacob S, Zarei M, Kenton A, Allroggen H. Gluten sensitivity and neuromyelitis optica: two case reports. J Neurol Neurosurg Psychiatry 76: 1028-1030, 2005.
34. Duffey P, Yee S, Reid IN, Bridges LR. Hashimoto's encephalopathy: postmortem findings after fatal status epilepticus. Neurology 61: 1124-1126, 2003.
35. Addolorato G, Di Giuda D, De Rossi G, et al. Regional cerebral hypoperfusion in patients with celiac disease. Am J Med 116: 312-317.
36. Zettinig G, Asenbaum S, Fueger BJ, et al. Increased prevalence of subclinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto's encephalitis? Clin Endocrinol (Oxf) 59: 637-643, 2003.