Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: In vitro, in vivo, and crystallographic results

Journal of Medicinal Chemistry

Volumn 52, Issue 13, 2009, Pages 3869-3880

  Song, Yongcheng ^a   Liu, Chia I ^b,c,d   Lin, Fu Yang ^a   Joo, Hwan No ^a   Hensler, Mary ^e   Liu, Yi Liang ^a   Jeng, Wen Yih ^b,c,d   Low, Jennifer ^f   Liu, George Y ^f   Nizet, Victor ^e   Wang, Andrew H J ^b,c,d   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 6 (4 PHENOXYPHENYL)HEXYLPHOSPHONIC ACID DIPOTASSIUM SALT; 3 (3 PHENOXYPHENYL)PROPYL PHOSPHONOACETATE DIPOTASSIUM SALT; 3 (3 PHENOXYPHENYL)PROPYLPHOSPHINYLMETHYLPHOSPHONIC ACID TRIPOTASSIUM SALT; ANTIBIOTIC AGENT; N [2 (3 PHENOXYPHENYL)ETHYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N [3 (3 (3,4 DICHLOROPHENOXY)PHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N [3 (3 (4 CHLOROPHENOXY)PHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONODIMETHYLACETAMIDE DIPOTASSIUM SALT; N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONOMALONAMIDE POTASSIUM SALT; N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONOMETHYLSUFAMIDE DIPOTASSIUM SALT; N [3 (3 PHENOXYPHENYL)PROPYL]SULFOACETAMIDE; N [3 (4 BIPHENYL)PROPYL]PHOSPHONOACETAMIDE; N [4 (3 PHENOXYPHENYL)BUTYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N HYDROXY 2 PHOSPHONO 5 (3 PHENOXYPHENYL)PENTAMIDE DIPOTASSIUM SALT; N HYDROXY N [3 (3 (3,4 DICHLOROPHENOXY)PHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N HYDROXY N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; N HYDROXY N [3 (4 METHYLBIPHENYL)PROPYL]PHOSPHONOACETAMIDE; N METHYL N [3 (3 PHENOXYPHENYL)PROPYL]PHOSPHONOACETAMIDE DIPOTASSIUM SALT; PHOSPHONOACETAMIDE DERIVATIVE; STAPHYLOXANTHIN; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; POLYMERIZATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; INHIBITORY CONCENTRATION 50; ORGANOPHOSPHORUS COMPOUNDS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS; XANTHOPHYLLS;

EID: 67649980377     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9001764     Document Type: Article

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