JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634

Journal of Antibiotics

Volumn 62, Issue 5, 2009, Pages 283-285

  Ueda, Jun Ya ^a   Hwang, Ji Hwan ^b   Maeda, Satoko ^c   Kato, Taira ^d   Ochiai, Atsushi ^d   Isshiki, Kunio ^d   Yoshida, Minoru ^c   Takagi, Motoki ^a   Shin Ya, Kazuo ^b  

^a Koto ku   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c RIKEN   (Japan)

^d MERCIAN CORPORATION   (Japan)

Author keywords

Histone deacetylase; Histone deacetylase inhibitor; Streptomyces; Trichostatin

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; JBIR 17; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL STRAIN; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

ANILINE COMPOUNDS; ENZYME INHIBITORS; FERMENTATION; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; SERINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES SP.;

EID: 67649976728     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.22     Document Type: Article

References (12)

1. Carew, J. S., Giles, F. J. & Nawrocki, S. T. Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy. Cancer Lett. 269, 7-17 (2008).
2. Shankar, S. & Srivastava, R. K. Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis. Adv. Exp. Med. Biol. 615, 261-298 (2008).
3. Tsuji, N., Kobayashi, M., Nagashima, K., Wakisaka, Y. & Koizumi, K. A new antifungal antibiotic, trichostatin. J. Antibiot. 29, 1-6 (1976).
4. Tsuji, N. & Kobayashi, M. Trichostatin C, a glucopyranosyl hydroxamate. J. Antibiot. 31, 939-944 (1978).
5. Numajiri, Y., Takahashi, T., Takagi, M., Shin-ya, K. & Doi, T. Total synthesis of largazole and its biological evaluation. Synlett. 16, 2483-2486 (2008).
6. Dressel, U., Renkawitz, R. & Baniahmad, A. Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer. Anticancer Res. 20, 1017-1022 (2000).
7. Shivashimpi, G. M. et al. Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg. Med. Chem. 15, 7830-7839 (2007).
8. Yoshida, M., Kijima, M., Akita, M. & Beppu, T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265, 17174-17179 (1990).
9. Furumai, R., Komatsu, Y., Nishino, N., Khochbin, S., Yoshida, M. & Horinouchi, S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc. Natl Acad. Sci. USA 98, 87-92 (2001).
10. Valenzuela-Fernandez, A., Cabrero, J. R., Serrador, J. M. & Sanchez-Madrid, F. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 18, 291-297 (2008).
11. Rodriguez-Gonzalez, A. et al. Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation. Cancer Res. 68, 2557-2560 (2008).
12. Matthias, P., Yoshida, M. & Khochbin, S. HDAC6 a new cellular stress surveillance factor. Cell Cycle 7, 7-10 (2008).