DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks

Oncology Reports

Volumn 21, Issue 6, 2009, Pages 1593-1597

  Schneider, Carolin C ^a   Hessenauer, Andrea ^b   Götz, Claudia ^a   Montenarh, Mathias ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

H2AX; Apoptosis; Kinase inhibitors; Protein kinase CK2; Reactive oxygen species

Indexed keywords

2 DIMETHYLAMINO 4,5,6,7 TETRABROMO 1H BENZIMIDAZOLE; BENZIMIDAZOLE; CASEIN KINASE II; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; TETRABROMOBENZOTRIAZOLE; TRIAZOLE; UNCLASSIFIED DRUG; 2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE; 4,5,6,7 TETRABROMOBENZOTRIAZOLE; 4,5,6,7-TETRABROMOBENZOTRIAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; TRIAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REDUCTION; SIGNAL TRANSDUCTION; CELL SURVIVAL; COMPARATIVE STUDY; DOUBLE STRANDED DNA BREAK; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATIVE STRESS; PROSTATE TUMOR; TIME; TUMOR CELL LINE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CASEIN KINASE II; CELL LINE, TUMOR; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; HUMANS; MALE; OXIDATIVE STRESS; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRIAZOLES; UP-REGULATION;

EID: 67649947497     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000392     Document Type: Article

References (27)

1. Litchfield DW: Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J 369: 1-15, 203.
2. Pinna LA and Meggio F: Protein kinase CK2 ('casein kinase-2') and its implication in cell division and proliferation. Prog Cell Cycle Res 3: 77-97, 1997.
3. Guerra B and Issinger OG: Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis 20: 391-408, 1999.
4. Xu X, Toselli PA, Russell LD and Seldin DC: Globozoospermia in mice lacking the casein kinase II α' catalytic subunit. Nat Genet 23: 118-121, 1999.
5. Unger GM, Davis AT, Slaton JW and Ahmed K: Protein kinase CK2 as regulator of cell survival: implications for cancer therapy. Curr Cancer Drug Targets 4: 77-84, 2004.
6. Duncan JS and Litchfield DW: Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta 1784: 33-47, 2008.
7. Zien P, Duncan JS, Skierski J, Bretner M, Litchfield DW and Shugar D: Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim Biophys Acta 1754: 271-280, 2005.
8. Duncan JS, Gyenis L, Lenehan J, Bretner M, Graves LM, Haystead TA and Litchfield DW: An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Mol Cell Proteomics 7: 1077-1088, 2008.
9. Prudent R, Moucadel V, Lopez-Ramos M, Aci S, Laudet B, Mouawad L, Barette C, Einhorn J, Einhorn C, Denis JN, Bisson G, Schmidt F, Roy S, Lafanechere L, Florent JC and Cochet C: Expanding the chemical diversity of CK2 inhibitors. Mol Cell Biochem 316: 71-85, 2008.
10. Pagano MA, Bain J, Kazimierczuk Z, Sarno S, Ruzzene M, Di Maira G, Elliott M, Orzeszko A, Cozza G, Meggio F and Pinna LA: The selectivity of inhibitors of protein kinase CK2. An update. Biochem J 415: 353-365, 2008.
11. Wang G, Unger G, Ahmad KA, Slaton JW and Ahmed K: Downregulation of CK2 induces apoptosis in cancer cells-a potential approach to cancer therapy. Mol Cell Biochem 274: 77-84, 2005.
12. Slaton JW, Unger GM, Sloper DT, Davis AT and Ahmed K: Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model. Cell Growth Differ 2: 712-721, 2004.
13. Lebrin F, Chambaz EM and Bianchini L: A role for protein kinase CK2 in cell proliferation: evidence using a kinase-inactive mutant of CK2 catalytic subunit α. Oncogene 20: 2010-2022, 2001.
14. Hamacher R, Saur D, Fritsch R, Reichert M, Schmid RM and Schneider G: Casein kinase II inhibition induces apoptosis in pancreatic cancer cells. Oncol Rep 18: 695-701, 2007.
15. Battistutta R, De Moliner E, Sarno S, Zanotti G and Pinna LA: Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole. Protein Sci 10: 2200-2206, 2001.
16. Battistutta R, Mazzorana M, Sarno S, Kazimierczuk Z, Zanotti G and Pinna LA: Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromobenzimidazole. Chem Biol 12: 1211-1219, 2005.
17. Kuenzel EA, Mulligan JA, Sommercorn J and Krebs EG: Substrat specificity determinants for casein kinase II as deduced from studies with synthetic peptides. J Biol Chem 262: 9136-9140, 1987.
18. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T 4. Nature 227: 680-682, 190.
19. Kuenzel EA and Krebs EG: A synthetic peptide substrate specific for casein kinase II. Proc Natl Acad Sci USA 82: 737-741, 1985.
20. Ueda S, Masutani H, Nakamura H, Tanaka T, Ueno M and Yodoi J: Redox control of cell death. Antioxid Redox Signal 4: 405-414, 2002.
21. Le Bras M, Clement MV, Pervaiz S and Brenner C: Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol 20: 205-219, 2005.
22. Sallmyr A, Fan J and Rassool FV: Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair. Cancer Lett 270: 1-9, 2008.
23. Lowndes NF and Toh GWL: DNA repair: the importance of phosphorylating histone H2AX. Curr Biol 15: R99-R102, 2005.
24. Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1-40, 2006.
25. Sauer H, Diedershagen H, Hescheler J and Wartenberg M: Calcium-dependence of hydrogen peroxide-induced c-fos expression and growth stimulation of multicellular prostate tumor spheroids. FEBS Lett 419: 201-205, 1997.
26. Sun XY, Donald SP and Phang JM: Testosterone and prostate specific antigen stimulate generation of reactive oxygen species in prostate cancer cells. Carcinogenesis 22: 1775-1780, 2001.
27. Ahmad KA, Wang G and Ahmed K: Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells. Mol Cancer Res 4: 331-338, 2006.