Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4213-4216

  Alagha, Ahmed ^a   Moman, Edelmiro ^a   Adamo, Mauro F A ^a   Nolan, Kevin B ^a   Chubb, Anthony J ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Acetylation; Arg120; Aspirin; COX; Inhibitor; Platelet aggregation; Prostaglandin H2 synthase; Ser530; Thrombosis; Tyr385

Indexed keywords

ACETIC ACID DERIVATIVE; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID DERIVATIVE; ACID ANHYDRIDE; ARACHIDONIC ACID; ARGININE; CARBOXYLIC ACID; ESTER DERIVATIVE; GLUTARIC ACID; MALEIC ANHYDRIDE; PYRIDINE; TETRACHLOROETHANE; TYROSINE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG ACETYLATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; HYDROGENATION; IC 50; MOLECULAR DOCKING; PROTEIN INTERACTION;

ARGININE; ASPIRIN; CARBOXYLIC ACIDS; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESTERS; HUMANS; PLATELET ACTIVATION; PLATELET AGGREGATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SERINE; THROMBOSIS; TYROSINE;

EID: 67649947131     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.120     Document Type: Article

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