A single intraoperative sub-Tenon's capsule injection of triamcinolone and ciprofloxacin in a controlled-release system for cataract surgery

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 7, 2009, Pages 3041-3047

  Paganelli, Fernando ^a,b,c   Cardillo, José A ^a,b,c   Melo Jr , Luiz A S ^b   Lucena, David R ^a   Silva Jr , Arnobio A ^d   Oliveira, Anselmo G ^d   Höfling Lima, Ana L ^b   Nguyen, Quan Dong ^e   Kuppermann, Baruch D ^f   Belfort Jr , Rubens ^b  

^a Hospital de Olhos de Araraquara   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c University of Araraquara   (Brazil)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; MICROSPHERE; POLYGLACTIN; PREDNISOLONE ACETATE; TIMOLOL MALEATE; TRIAMCINOLONE ACETONIDE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PREDNISOLONE;

AGED; ANTERIOR EYE CHAMBER; ARTICLE; BIOMICROSCOPY; CATARACT; CATARACT EXTRACTION; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HUMAN; INTRAOCULAR PRESSURE; INTRAOCULAR PRESSURE ABNORMALITY; LENS IMPLANTATION; MAJOR CLINICAL STUDY; MALE; OPHTHALMOSCOPY; PHACOEMULSIFICATION; POSTOPERATIVE CARE; POSTOPERATIVE INFECTION; POSTOPERATIVE INFLAMMATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME; VISUAL ACUITY; ACOUSTIC MICROSCOPY; BACTERIAL EYE INFECTION; COMPARATIVE STUDY; CONNECTIVE TISSUE; DELAYED RELEASE FORMULATION; DRUG COMBINATION; INFLAMMATION; INJECTION; IRIDOCYCLITIS; PATHOLOGY; PEROPERATIVE CARE; POSTOPERATIVE COMPLICATION;

AGED; ANTERIOR CHAMBER; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; CIPROFLOXACIN; CONNECTIVE TISSUE; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; DRUG CARRIERS; DRUG THERAPY, COMBINATION; EYE INFECTIONS, BACTERIAL; FEMALE; HUMANS; INFLAMMATION; INJECTIONS; INTRAOCULAR PRESSURE; INTRAOPERATIVE CARE; LACTIC ACID; LENS IMPLANTATION, INTRAOCULAR; MALE; MICROSCOPY, ACOUSTIC; OPHTHALMOSCOPY; PHACOEMULSIFICATION; POLYGLYCOLIC ACID; POSTOPERATIVE COMPLICATIONS; PREDNISOLONE; TRIAMCINOLONE ACETONIDE; UVEITIS, ANTERIOR;

EID: 67649946242     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2920     Document Type: Article

References (50)

1. Sanders DR, Kraff M. Steroidal and nonsteroidal anti-inflammatory agents: effect on postsurgical inflammation and blood-aqueous humor barrier breakdown. Arch Ophthalmol. 1984;102:1453-1456.
2. Ferguson VMG, Spalton DJ. Recovery of the blood-aqueous barrier after cataract surgery. Br J Ophthalmol. 1991;75:106-110.
3. Winfield AJ, Jessiman D, Williams A, Esakowitz L. A study of the causes of non-compliance by patients prescribed eyedrops. Br J Ophthalmol. 1990;74:477-480.
4. Tan DTH, Chee SP, Lim L, Lim AS. Randomized clinical trial of a new dexamethasone delivery system (Surodex) for treatment of post-cataract surgery inflammation. Ophthalmology. 1999;106: 223-231.
5. Chang DF, Garcia IH, Hunkeler JD, Minas T. Phase II results of an intraocular steroid delivery system for cataract surgery. Ophthalmology. 1999;106:1172-1177.
6. Tan DTH, Chee SP, Lim L, et al. Randomized clinical trial of Surodex steroid drug delivery system for cataract surgery: anterior versus posterior placement of two Surodex in the eye. Ophthalmology. 2001;108:2172-2181.
7. Wadood AC, Armbrecht AM, Aspinall PA, Dhillon B. Safety and efficacy of a dexamethasone anterior segment drug delivery system in patients after phacoemulsification. J Cataract Refract Surg. 2004;30:761-768.
8. Helm CJ, Holland GN. The effects of posterior subtenon injection of triamcinolone acetonide in patients with intermediate uveitis. Am J Ophthalmol. 1995;120:55-64.
9. Zamir E, Read RW, Smith RE, et al. A prospective evaluation of subconjunctival injection of triamcinolone acetonide for resistant anterior scleritis. Ophthalmology. 2002;109:798-805.
10. Dafflon ML, Tran VT, Guex-Crosier Y, Herbort CP. Posterior sub-Tenon's steroid injections for the treatment of posterior ocular inflammation: indications, efficacy and side effects. Graefes Arch Clin Exp Ophthalmol. 1999;237:289-295.
11. Stern AL, Taylor DM, Dalburg LA, Cosentino RT. Pseudophakic cystoid maculopathy: a study of 50 cases. Ophthalmology. 1981; 88:942-946.
12. Suckling RD, Maslin KF. Pseudophakic cystoid macular oedema and its treatment with local steroids. Aust N Z J Ophthalmol. 1988;16:353-359.
13. Thach AB, Dugel PU, Flindall RJ, et al. A comparison of retrobulbar versus sub-Tenon's corticosteroid therapy for cystoid macular edema refractory to topical medications. Ophthalmology. 1997; 104:2003-2008.
14. Yoshikawa K, Kotake S, Ichiishi A, et al. Posterior sub-Tenon injections of repository corticosteroids in uveitis patients with cystoid macular edema. Jpn J Ophthalmol. 1995;39:71-76.
15. Walton RC, Vick VL, Greenwald MA. Sub-Tenon's corticosteroid for the treatment of macular edema in bone marrow transplant retinopathy. Retina. 1999;19:171-173.
16. Cardillo JA, Melo LAS Jr, Costa RA, et al. Comparison of intravitreal versus posterior sub-Tenon's capsule injection of triamcinolone acetonide for diffuse diabetic macular edema. Ophthalmology. 2005;112:1557-1563.
17. Paganelli F, Cardillo JA, Melo LAS Jr, Brazilian Ocular Pharmacology and Pharmaceutical Technology Research Group. A single intraoperative sub-Tenon's capsule triamcinolone acetonide injection for the treatment of post-cataract surgery inflammation. Ophthalmology. 2004;111:2102-2108.
18. Negi AK, Browning AC, Vernon SA. Single perioperative triamcinolone injection versus standard postoperative steroid drops after uneventful phacoemulsification surgery: randomized controlled trial. J Cataract Refract Surg. 2006;32:468-474.
19. West ES, Behrens A, McDonnell PJ, et al. The incidence of endophthalmitis after cataract surgery among the U.S. Medicare population increased between 1994 and 2001. Ophthalmology. 2005; 112:1388-1394.
20. Taban M, Behrens A, Newcomb RL, et al. Acute endophthalmitis following cataract surgery: a systematic review of the literature. Arch Ophthalmol. 2005;123:613-620.
21. Barry P, Seal DV, Gettinby G, ESCRS Endophthalmitis Study Group. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery. Preliminary report of principal results from a European multicenter study. J Cataract Refract Surg. 2006;32: 407-410.
22. Behrens-Baumann W, Martell J. Ciprofloxacin concentration in the rabbit aqueous humor and vitreous following intravenous and subconjunctival administration. Infection. 1988;16:54-57.
23. Barza M. Antibacterial agents in the treatment of ocular infections. Infect Dis Clin North Am. 1989;3:533-551.
24. Geroski DH, Edelhauser HF. Transscleral drug delivery for posterior segment disease. Adv Drug Deliv Rev. 2001;52:37-48.
25. Starr MB, Lally JM. Antimicrobial prophylaxis for ophthalmic surgery. Surv Ophthalmol. 1995;39:485-501.
26. Clements DB, Tailor V. A study of aqueous and serum levels of ceftazidime following subconjunctival administration. Br J Ophthalmol. 1987;71:433-435.
27. Prausnitz MR, Noonan JS. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J Pharm Sci. 1998;87:1479-1488.
28. Lehmann OJ, Roberts CJ, Ikram K, et al. Association between nonadministration of subconjunctival cefuroxime and postoperative endophthalmitis. J Cataract Refract Surgery. 1997;23:889-893.
29. Colleaux KM, Hamilton WK. Effect of prophylactic antibiotics and incision type on the incidence of endophthalmitis after cataract surgery. Can J Ophthalmol. 2000;35:373-378.
30. Buzard K, Liapis S. Prevention of endophthalmitis. J Cataract Refract Surgery. 2004;30:1953-1959.
31. Chylack LT Jr, Wolfe JK, Singer DM, et al. The Lens Opacities Classification System III: The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111:831-836.
32. Behrens-Baumann W, Theuring S, Frey B, et al. Ciclosporin concentration in the rabbit aqueous humor and cornea following subconjunctival administration. Graefes Arch Clin Exp Ophthalmol. 1986;224:368-370.
33. Hogan MJ, Kimura SJ, Thygeson P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959;47:155-170.
34. Newcombe RG. Confidence intervals for an effect size measure based on the Mann-Whitney statistic: part 1: general issues and tail-area-based methods. Stat Med. 2006;28(25):543-557.
35. Kim SY, Yang J, Lee YC, Park YH. Effect of a single intraoperative sub-Tenon injection of triamcinolone acetonide on the progression of diabetic retinopathy and visual outcomes after cataract surgery. J Cataract Refract Surg. 2008;34(5):823-826.
36. Morgan CM, Schatz H, Vine AK, et al. Ocular complications associated with retrobulbar injections. Ophthalmology. 1988;95:660-665.
37. McLean EB. Inadvertent injection of corticosteroid into the choroidal vasculature. Am J Ophthalmol. 1975;80:835-837.
38. Ellis PP. Occlusion of the central retina artery after retrobulbar corticosteroid injection. Am J Ophthalmol. 1978;85:352-356.
39. Giles CL. Bulbar perforation during periocular injection of corticosteroids. Am J Ophthalmol. 1974;77:438-441.
40. Schlaegel TF, Wilson FM. Accidental intraocular injection of depot corticosteroids. Trans Am Acad Ophthalmol Otolaryngol. 1974; 78:847-855.
41. Schechter RJ. Management of inadvertent intraocular injections. Ann Ophthalmol. 1985;17:771-775.
42. Ellis PP. Retrobulbar injections. Surv Ophthalmol. 1974;18:425-430.
43. Nozik RA. Orbital rim fat atrophy after repository periocular corticosteroid injection. Am J Ophthalmol. 1976;82:928-930.
44. O'Connor GR. Periocular corticosteroid injections: uses and abuses. Eye Ear Nose Throat Mon. 1976;55:83-88.
45. Mathias CGT, Maibach HI, Ostler HB, et al. Delayed hypersensitivity to retrobulbar injections of methylprednisolone acetate. Am J Ophthalmol. 1978;86:816-819.
46. Herschler J. Increased intraocular pressure induced by repository corticosteroids. Am J Ophthalmol. 1976;82:90-93.
47. Akduman L, Kolker AE, Black DL, et al. Treatment of persistent glaucoma secondary to periocular corticosteroids. Am J Ophthalmol. 1996;122:275-277.
48. Moritera T, Ogura Y, Honda Y, et al. Microspheres of biodegradable polymers as a drug-delivery system in the vitreous. Invest Ophthalmol Vis Sci. 1991;32:1785-1790.
49. Kimura H, Ogura Y, Moritera T, et al. Injectable microspheres with controlled drug release for glaucoma filtering surgery. Invest Ophthalmol Vis Sci. 1992;33:3436-3441.
50. Kompella UB, Bandi N, Ayalasomayajula SP. Subconjunctival nanoand microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression. Invest Ophthalmol Vis Sci. 2003;44:1192-1201.