Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG)

American Journal of Medical Genetics, Part A

Volumn 149, Issue 7, 2009, Pages 1375-1381

  Hendricks, Audrey E ^a   Latourelle, Jeanne C ^b   Lunetta, Kathryn L ^a   Cupples, L Adrienne ^a   Wheeler, Vanessa ^c   MacDonald, Marcy E ^c   Gusella, James F ^c   Myers, Richard H ^b  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

De novo; Genetic counseling; High normal alleles; Huntington disease; Intermediate alleles; Mutable normal alleles

Indexed keywords

ARTICLE; BIRTH RATE; BOOTSTRAPPING; DISEASE TRANSMISSION; GENE FREQUENCY; GENETIC COUNSELING; GENETIC LINKAGE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; INCIDENCE; MALE; PATERNITY; PRIORITY JOURNAL; PROBABILITY; PROGENY;

ADULT; ALLELES; GENOTYPE; HETEROZYGOTE; HUMANS; HUNTINGTON DISEASE; INHERITANCE PATTERNS; MALE; MIDDLE AGED; MODELS, GENETIC; MODELS, STATISTICAL; PENETRANCE; TRINUCLEOTIDE REPEAT EXPANSION; YOUNG ADULT;

EID: 67649887838     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.32901     Document Type: Article

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