Breast cancer resistance protein/ABCG2 is differentially regulated downstream of extracellular signal-regulated kinase

Cancer Science

Volumn 100, Issue 6, 2009, Pages 1118-1127

  Imai, Yasuo ^a   Ohmori, Kyoko ^b   Yasuda, Shin'ichi ^b   Wada, Mariko ^b   Suzuki, Tsukasa ^a   Fukuda, Kazunori ^b   Ueda, Yoshihiko ^a  

^a Department of Pathology ^*  (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEASOME INHIBITOR; PROTEIN P90; S6 KINASE; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; NITRILE; PRIMER DNA; TUMOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION; BREAST TUMOR; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ONCOGENE MYC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; BUTADIENES; CELL LINE, TUMOR; DNA PRIMERS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; NEOPLASM PROTEINS; NITRILES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; UP-REGULATION;

EID: 67649868141     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01154.x     Document Type: Article

References (29)

1. Allikmets R, Schriml L, Hutchinson A, Romano-Spica V, Dean M. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 1998, 58:5337-9.
2. Doyle LA, Yang W, Abruzzo LV. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998, 95:15665-70.
3. Miyake K, Mickley L, Litman T. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res 1999, 59:8-13.
4. Zhou S, Schuetz JD, Bunting KD. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature Med 2001, 7:1028-34.
5. Jonker JW, Buitelaar M, Wagenaar E. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci USA 2002, 99:15649-54.
6. van Herwaarden AE, Jonker JW, Wagenaar E. The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res 2003, 63:6447-52.
7. Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y. Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol 2003, 64:610-8.
8. Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y. ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 2003, 278:22644-9.
9. Maliepaard M, van Gastelen MA, de Jong LA. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res 1999, 59:4559-63.
10. Kawabata S, Oka M, Shiozawa K. Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochem Biophys Res Commun 2001, 280:1216-23.
11. Yanase K, Tsukahara S, Asada S, Ishikawa E, Imai Y, Sugimoto Y. Gefitinib reverses breast cancer resistance protein-mediated drug resistance. Mol Cancer Ther 2004, 3:1119-25.
12. Imai Y, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y. Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res 2002, 93:231-5.
13. Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T. Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther 2003, 2:105-12.
14. Imai Y, Tsukahara S, Asada S, Sugimoto Y. Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res 2004, 64:4346-52.
15. Imai Y, Ishikawa E, Asada S, Sugimoto Y. Estrogen-mediated post transcriptional down-regulation of breast cancer resistant protein/ABCG2. Cancer Res 2005, 65:596-604.
16. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26:3291-310.
17. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method. Methods 2001, 25:402-8.
18. Smith JA, Poteet-Smith CE, Xu Y, Errington TM, Hecht SM, Lannigan DA. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res 2005, 65:1027-34.
19. Wakabayashi K, Nakagawa H, Tamura A. Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein. J Biol Chem 2007, 282:27841-6.
20. Wang H, Zhou L, Gupta A. Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Am J Physiol Endocrinol Metab 2006, 290:E798-807.
21. Krishnamurthy P, Ross DD, Nakanishi T. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 2004, 279:24218-25.
22. Szatmari I, Vámosi G, Brazda P. Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. J Biol Chem 2006, 281:23812-23.
23. Meyer zu Schwabedissen HE, Grube M, Dreisbach A. Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos 2006, 34:524-33.
24. Nakagawa H, Tamura A, Wakabayashi K. Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2. Biochem J 2008, 411:623-31.
25. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994, 79:13-21.
26. Mellman I. Endocytosis and molecular sorting. Annu Rev Cell Dev Biol 1996, 12:575-625.
27. Hochstrasser M. Ubiquitin-dependent protein degradation. Annu Rev Genet 1996, 30:405-39.
28. Kopito RR. ER quality control: the cytoplasmic connection. Cell 1997, 88:427-30.
29. Katayama K, Yoshioka S, Tsukahara S, Mitsuhashi J, Sugimoto Y. Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. Mol Cancer Ther 2007, 6:2092-102.