Andrographolactone, a unique diterpene from Andrographis paniculata

Tetrahedron Letters

Volumn 50, Issue 34, 2009, Pages 4824-4826

  Wang, Guo Cai ^a,b   Wang, Ying ^a   Williams, Ian D ^c   Sung, Herman Ho Yung ^c   Zhang, Xiao Qi ^a   Zhang, Dong Mei ^a   Jiang, Ren Wang ^a   Yao, Xin Sheng ^a   Ye, Wen Cai ^a,b  

^a JINAN UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Acanthaceae; Andrographis paniculata; Andrographolactone; Diterpene

Indexed keywords

ANDROGRAPHOLACTONE; DITERPENE; UNCLASSIFIED DRUG;

ANDROGRAPHIS PANICULATA; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFRARED SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE MEASUREMENT; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY DIFFRACTION;

ACANTHACEAE; ANDROGRAPHIS PANICULATA;

EID: 67649856628     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.05.097     Document Type: Article

References (10)

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7. Plant Material: The aerial parts of A. paniculata were collected in Ruijin county, Jianxi province of China, in July of 2005, and were authenticated by Professor Min-Jian Qin of China Pharmaceutical University. A voucher specimen (No. 050711) was deposited in the herbarium of China Pharmaceutical University, Nanjing.
8. 5, 125 MHz) data, see Table 1.
9. -3 (CCDC deposition number: CCDC 679530).
10. 4 cells/well) were treated with various concentrations of compound 1 in 96-well culture plates (Costar, USA) for 48 h. After that, cells were cultured with MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) for 4 h at 37 °C. The formazan crystal formed was dissolved with DMSO, and the absorbance was colorimetrically measured at 570 nm. Data represent the mean value of three independent experiments.