Treatment of keloid scars post-shave excision with imiquimod 5% cream: A prospective, double-blind, placebo-controlled pilot study

Journal of Drugs in Dermatology

Volumn 8, Issue 5, 2009, Pages 455-458

  Berman, Brian ^a   Harrison Balestra, Catherine ^a   Perez, Oliver A ^a   Viera, Martha ^a   Villa, Adriana ^a   Zell, Deborah ^a   Ramirez, Claudia ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMIQUIMOD; PLACEBO; AMINOQUINOLINE DERIVATIVE; IMMUNOLOGICAL ADJUVANT;

APPLICATION SITE PAIN; APPLICATION SITE PRURITUS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; KELOID; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; TOPICAL TREATMENT; TREATMENT OUTCOME; ADOLESCENT; ADULT; AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG ADMINISTRATION; MIDDLE AGED; POSTOPERATIVE COMPLICATION; TOPICAL DRUG ADMINISTRATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; AMINOQUINOLINES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; HUMANS; KELOID; MIDDLE AGED; PILOT PROJECTS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RECURRENCE; TREATMENT OUTCOME;

EID: 67649855094     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Shaffer JJ, Taylor SC, Cook-Bolden F. Keloidal scars: A review with a critical look at therapeutic options. J Am Acad Dermatol. 2002;46(2 Suppl): S63-S97. (Pubitemid 41127933)
2. Rockwell WB, Cohen IK, Ehrlich HP. Keloids and hypertrophic scars: A comprehensive review. Plas Reconstr Surg. 1989;84(5): 827-837. (Pubitemid 19286117)
3. Berman B and Bieley HC. Keloids. J Am Acad Dermatol. 1995;33(1): 117-123.
4. Elias JA, Jimenez SA, Freundlich B. Recombinant gamma, alpha and beta interferon regulation of human lung fibroblast proliferation. Am Rev Respir Dis. 1987;135(1): 62-65. (Pubitemid 17223890)
5. McCauley RL, Chopra V, Li YY, et al. Altered cytokine production in black patients with keloids. J Clin Immunol. 1992;12(4): 300-308.
6. Berman B, Duncan MR. Short-term keloid treatment in vivo with human interferon-alpha-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro. J Am Acad Dermatol. 1989;21(4 Pt 1): 694-706.
7. Berman B, Kaufman J. Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids. J Am Acad Dermatol. 2002;47(4 Suppl): S209-S211.
8. Stashower ME. Successful treatment of earlobe keloids with imiquimod after tangential shave excision. Dermatol Surg. 2006;32(3): 380-386.
9. Marin-Garcia R and Busquets MD. Postsurgical use of imiquimod 5% cream in the prevention of earlobe keloid recurrences: Results of an open-label, pilot study. Dermatol Surg 2005;31: 1394-1398.
10. Prado A, Andrades P, Benitez S, Umaña M. Scar management after breast surgery: Preliminary results of a prospective, randomized, and double-blind clinical study with aldara cream 5% (imiquimod). Plast Reconstr Surg. 2005;115(3): 966-972. (Pubitemid 40316466)
11. Chuangsuwanich A, Gunjittisomram S. The efficacy of 5% imiquimod cream in the prevention of recurrence of excised keloids. J Med Assoc Thai. 2007;90(7): 1363-1367. (Pubitemid 47414510)
12. Sclafani AP, Gordon L, Chadha M, Romo T III. Prevention of earlobe keloid recurrence with postoperative coricosteroid injections versus radiation therapy: A randomized, prospective study and review of the literarure. Dermatol Surg. 1996;22(6): 569-574. (Pubitemid 26200115)
13. Lawrence WT. In search of the optimal treatment of keloids: Report of a series and review of the literature. Ann Plas Surg. 1991;27(2): 164-178.
14. Hemmi H, Kaisho T, Takeuchi O, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002;3(2): 196-200. (Pubitemid 34141451)