Alkalization of blood pH is responsible for survival of cancer patients by mild hyperthermia

Biomedical Research

Volumn 30, Issue 2, 2009, Pages 95-100

  Ohishi, Takahiko ^a   Nukuzuma, Chiyoko ^a   Seki, Akira ^b   Watanabe, Mayumi ^c   Tomiyama Miyaji, Chikako ^d   Kainuma, Eisuke ^c   Inoue, Masashi ^c   Kuwano, Yuh ^c   Abo, Toru ^c  

^a ThermoVision   (Japan)

^b Izu Preventive and Alternative Clinic Center   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ALKALINIZATION; ARTICLE; BLOOD PH; CANCER PATIENT; CANCER SURVIVAL; CARBON DIOXIDE TENSION; CLINICAL ARTICLE; FEMALE; HUMAN; HYPERTHERMIC THERAPY; MALE; OXYGEN TENSION; RECTUM TEMPERATURE; BLOOD; BLOOD GAS ANALYSIS; DISEASE FREE SURVIVAL; MIDDLE AGED; NEOPLASM; PH;

CARBON DIOXIDE; OXYGEN;

ADULT; AGED; BLOOD GAS ANALYSIS; CARBON DIOXIDE; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTHERMIA, INDUCED; MALE; MIDDLE AGED; NEOPLASMS; OXYGEN;

EID: 67649823708     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.30.95     Document Type: Article

References (20)

1. Abo T, Kawamura T, Kawamura H, Tomiyama-Miyaji C and Kanda Y (2007) Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors. Immunol Res 37, 201-210.
2. Belpomme D, Irigaray P, Hardell L, Clapp R, Montagnier L, Epstein S and Sasco AJ (2007) The multitude and diversity of environmental carcinogens. Environ Res 105, 414-429.
3. Clapp RW, Howe GK and Jacobs MM (2007) Environmental and occupational causes of cancer: a call to act on what we know. Biomed Pharmacother 61, 631-639.
4. Husgafvel-Pursiainen K (2004) Genotoxicity of environmental tobacco smoke: a review. Mutation Res 567, 427-445.
5. Katiyar SK (2007) UV-induced immune suppression and photocarcinogenesis: chemoprevention by dietary botanical agents. Cancer Lett 255, 1-11.
6. Kawai N, Ito A, Nakahara Y, Hutakuchi M, Shirai T, Honda H, Kobayashi T and Kohri K (2005) Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. Prostate 64, 373-381.
7. Okada F (2007) Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression. Int J Cancer 121, 2364-2372.
8. Page RL, Meyer RE, Thrall DE and Dewbirst MW (1987) Cardiovascular and metabolic response of tumour-bearing dogs to whole body hyperthermia. Int J Hyperthermia 3, 513-525.
9. Sagiyama K, Tsuchida M, Kawamura H, Wang S, Li C, Bai X, Nagura T, Nozoe S and Abo T (2004) Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves. Clin Exp Immunol 135, 56-63.
10. Salnikow K and Zhitkovich A (2008) Genetic and epigenetic mechanisms in mental carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21, 28-44.
11. Shakil A, Osborn JL and Song CW (1999) Changes in oxygenation status and blood flow in a rat tumor model by mild temperature hyperthermia. Int J Radiat Oncol Biol Phys 43, 859-865.
12. Steinhausen D, Mayer WK, and von Ardenne M (1994) Evaluation of systemic tolerance of 42.0 degrees C infirared - A whole-body hyperthermia in combination with hyperglycemia and hyperoxemia. A phase-I study. Strahlenther Onkol 170, 322-334.
13. Suzuki S, Toyabe S, Moroda T, Tada T, Tsukahara A, Iiai T, Minagawa M, Maruyama S, Hatakeyama K, Endo K and Abo T (1997) Circadian rhythm of leukocytes and lymphocyte subsets and its possible correlation with the function of autonomic nervous system. Clin Exp Immunol 110, 500-508.
14. Tomiyama-Miyaji C, Watanabe M, Ohishi T, Kanda Y, Kainuma E, Bakir HY, Shen JW, Ren HW, Inoue M, Tajima K, Bai X and Abo T (2007) Modulation of the endocrine and immune systems by well-controlled hyperthermia equipment. Biomed Res 28, 119-125.
15. Toyabe S, Iiai T, Fukuda M, Kawamura T, Suzuki S, Uchiyama M and Abo T (1997) Identification of nicotinic acetylcholine receptors on lymphocytes in the periphery as well as thymus in mice. Immunology 92, 201-205.
16. Urakawa T, Nukuzuma C, Ohtsuka K, Kawata M, Shibazaki A, Hasegawa T and Katamoto H (2006) Effects of experimental hyperthermia on biodynamics and immunity in dogs and cats. Jpn J Hyperthemic Oncol 22, 35-47.
17. Vendetti S, Cicconi R, Piselli P, Vismara D, Cassol M and Delpino A (2000) Induction and membrane expression of heat shock proteins in heat-treated HPC-4 cells is correlated with increased resistance to LAK-mediated lysis. J Exp Clin Cancer Res 19, 329-334.
18. von Ardenne M (1994) Principles and concept 1993 of the systemic cancer multistep therapy (sCMT). Extreme wholebody hyperthermia using the infrared- a technique IRATHERM 2000-selective thermosensitisation by hyperglycemia-circulatory back-up by adapted hyperoxemia. Strahlenther Onkol 170, 581-589.
19. Watanabe M, Tomiyama-Miyaji C, Kainuma E, Inoue M, Kuwano Y, Ren HW, Shen JW and Abo T (2008) Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Immunol Lett 115, 43-49.
20. Zhang WG, Liu SH, Cao XM, Cheng YX, Ma XR, Yang Y and Wang YL (2005) A phase-I clinical trial of active immunotherapy for acute leukemia using inactivated autologous leukemia cells mixed with IL-2, GM-CSF, and IL-6. Leuk Res 29, 3-9.