Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: Determinants of nucleotide specificity

Journal of Biological Chemistry

Volumn 284, Issue 21, 2009, Pages 14286-14295

  Satapathy, Ajit K ^a   Crampton, Donald J ^a,b   Beauchamp, Benjamin B ^a   Richardson, Charles C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CLARK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSE PROXIMITY; DNA HELICASE; DNA UNWINDING; DUPLEX DNA; HELICASE; HELICASE ACTIVITIES; HELICASES; HYDROGEN BRIDGES; IN-VITRO; INDUCED-FIT MECHANISM; MULTIFUNCTIONAL PROTEIN; NUCLEOTIDE-BINDING SITES; REPLICATION FORK; WILD TYPES;

AMINO ACIDS; BACTERIOPHAGES; BINDING ENERGY; BINDING SITES; DNA; GENES; HYDROGEN; HYDROLYSIS; NUCLEOTIDES; SUGAR (SUCROSE); SUGARS;

NUCLEIC ACIDS;

ARGININE; BACTERIOPHAGE DNA; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; HELICASE; NUCLEOTIDE; SERINE; T7 DNA HELICASE; THREONINE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; DNA; DNA DIRECTED DNA POLYMERASE; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; PYRIMIDINE NUCLEOTIDE; THYMIDINE 5'-TRIPHOSPHATE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIOPHAGE T7; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA DENATURATION; DNA SYNTHESIS; ENZYME SPECIFICITY; NONHUMAN; NUCLEOTIDE BINDING SITE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HYDROLYSIS; KINETICS; METABOLISM; PLASMID; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ARGININE; BACTERIOPHAGE T7; CRYSTALLOGRAPHY, X-RAY; CYTIDINE TRIPHOSPHATE; DNA; DNA HELICASES; DNA-DIRECTED DNA POLYMERASE; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; KINETICS; MUTANT PROTEINS; NUCLEOTIDES; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES;

EID: 67649803032     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900557200     Document Type: Article

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