High doses of GnRH antagonists are efficient in the management of severe ovarian hyperstimulation syndrome

Clinical and Experimental Obstetrics and Gynecology

Volumn 36, Issue 2, 2009, Pages 78-81

  Bonilla Musoles, F M ^a,c   Raga, F ^a   Castillo, J C ^a   Sanz, M ^a   Dolz, M ^a   Osborne, N ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD DE PANAMÁ   (Panama)

^c NONE   (Spain)

Author keywords

GnRH antagonists; Ovarian hyperstimulation syndrome

Indexed keywords

CETRORELIX; ESTRADIOL; GONADORELIN ANTAGONIST;

ADULT; ARTICLE; ASCITES; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; HEMATOCRIT; HEMOCONCENTRATION; HUMAN; OVARY HYPERSTIMULATION; PARACENTESIS; PERITONEAL FLUID;

ADULT; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; OVARIAN HYPERSTIMULATION SYNDROME; PILOT PROJECTS;

EID: 67649768652     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Latouche J., Crumeyrolle-Arias M., Jordan D., Kopp N., Augendre-Ferrante B., Cedard L., Haour F.: "GnRH receptors in human granulosa cells: anatomical localization by autoradiographic study". Endocrinology, 1989, 125, 1739.
2. Minaretzis D., Jakubowski M., Mortola J.F., Pavlou S.N.: "Gonadotropin-releasing hormone receptor gene expression in the human ovary and granulosa-lutein cells". J. Clin. Endocrinol. Metab., 1995, 80, 430.
3. Raga F., Casañ E.M., Wen Y., Huang H.Y., Bonilla-Musoles F., Polan M.L.: "Independent regulation of Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), and TIMP-3 in human endometrial stromal cells by gonadotropin-releasing hormone: Implications in early human implantation". J. Clin. Endocrinol. Metab., 1999, 84, 636. (Pubitemid 29075698)
4. Raga F., Casañ E.M., Bonilla-Musoles F., Polan M.L.: "Immunostimulatory properties of Gonadotropin-releasing hormone (GnRH) in human endometrium: possible paracrine/autocrine role in embryonic implantation". Biol. Reprod., 2000, 61, 561.
5. Raga F., Casañ E.M., Kruessel J.S., Wen Y., Huang H.Y., Nezhat C., Polan M.L.: "Quantitative gonadotropin-releasing hormone gene expression and immunohistochemical localization in human endometrium throughout the menstrual cycle". Biol. Reprod., 1998, 59, 661. (Pubitemid 28395084)
6. Raga F., Casañ E.M., Kruessel J.S.: "Gonadotrophin releasing hormone modulation of vascular endothelial growth factor and its transmembrane receptors FLT-1, KDR and sFLT-1: role in early embryonic implantation". Hum. Reprod., 1999, 14, 106.
7. Raga F., Casañ E.M., Kruessel J., Wen Y., Bonilla-Musoles F., Polan M.L.: "The role of gonadotropin-releasing hormone in murine preimplantation embryonic development". Endocrinology, 1999, 140, 3705. (Pubitemid 30645426)
8. Raga F., Casan E.M.: "Biological actions of GnRH antagonist: Clinical implications in fertilization, early embryonic development, and implantation". Hum. Reprod., 2000, 15, 216.
9. Pellicer A., Miró F.: "Steroidogenesis in vitro of human granulosaluteal cells pretreated in vivo with gonadotropin-releasing hormone analogs". Fertil. Steril., 1990, 54, 590. (Pubitemid 20350643)
10. Friden B.E., Nilsson L.: "Gonadotrophin-releasing hormone-antagonist luteolysis during the preceding mid-luteal phase is a feasible protocol in ovarian hyperstimulation before in vitro fertilization". Acta Obstet. Gynecol. Scand., 2005, 84, 812. (Pubitemid 41039908)
11. Humaidan P., Bungum L., Bungum M., Hald F., Agerholm I., Blaabjerg J. et al.: "Reproductive outcome using a GnRH antagonist (cetrorelix) for luteolysis and follicular synchronization in poor responder IVF/ICSI patients treated with a flexible GnRH antagonist protocol". Reprod. Biomed Online, 2005, 11, 679. (Pubitemid 43009260)
12. Orvieto R.: "Prediction of ovarian hyperstimulation syndrome. Challenging the estradiol mythos". Human Reprod., 2003, 18, 665.
13. Bonilla-Musoles F.: "Ecografía vaginal: Doppler y tridimensión". Madrid, Panamericana, 2000.
14. Orvieto R., Schwartz A., Bar Hava I., Abir R., Ashkenazi J., La-Marca A., Ben Rafael Z.: "Controlled ovarian hyperstimulation: a state of endothelial activation". Am. J. Reprod. Immunol., 2000, 44, 257.
15. Orvieto R., Ben Rafael Z., Schwartz A., Abir R., Fisch B., La-Marca A., Bar Hava I.: "Soluble L-selectin levels during controlled ovarian hyperstimulation". Gynecol. Endocrinol., 2001, 15, 29. (Pubitemid 32234885)
16. De Jong D., Macklon N., Mannaerts B., Coelingh Bennink H., Fauser B.: "High dose gonadotrophin-releasing hormone antagonist (ganirelix) may prevent ovarian hyperstimulation syndrome caused by ovarian stimulation for in-vitro fertilization". Hum. Reprod., 1998, 13, 573. (Pubitemid 28171949)
17. Dubourdieu S., Charbonnel B., D'Acremont M.F., Carreau S., Spitz I.M., Bouchard P.: "Effect of administration of a gonadotropin-releasing hormone (GnRH) antagonist (Nal-Glu) during the periovulatory period the luteinizing hormone surge requires secretion of GnRH". J. Clin. Endocrinol. Metab., 1994, 78, 343. (Pubitemid 24061751)
18. Lainas T.G., Sfontouris I.A., Zorzovilis I.Z., Petsas G.K., Lainas G.T., Kalibianakis E.M.: "Management of severe early ovarian hyperstimulation by re-initiation of GnRH antagonist". Reprod. Biomed. Online, 2007, 15, 408. (Pubitemid 47565008)