Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of CaV1.2

Channels

Volumn 2, Issue 3, 2008, Pages 216-223

  Stary, Anna ^a,d   Kudrnac, Michaela ^b   Beyl, Stanislav ^b   Hohaus, Annette ^b   Timin, Eugen N ^b   Wolschann, Peter ^a   Guy, H Robert ^c   Hering, Steffen ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

CaV1.2; Calcium channel; Channel activation; Channelopathy; MD simulation; Mutagenesis

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; ION; L-TYPE CALCIUM CHANNEL ALPHA(1C);

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; BIOLOGICAL MODEL; BIOLOGY; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFOCAL MICROSCOPY; CONFORMATION; MEMBRANE POTENTIAL; METABOLISM; MUTATION; PROCEDURES; PROTEIN SECONDARY STRUCTURE; STATISTICAL MODEL; TIME;

CALCIUM CHANNELS, L-TYPE; CELL LINE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; IONS; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MODELS, STATISTICAL; MOLECULAR CONFORMATION; MUTATION; PROTEIN STRUCTURE, SECONDARY; TIME FACTORS;

EID: 67649687309     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.2.3.6160     Document Type: Article

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