Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: A study of 627 patients with trauma

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 5, 2009, Pages 1265-1270

  Morris, John A ^a,d   Francois, Cedric ^b   Olson, Paul K ^b   Cotton, Bryan A ^e   Summar, Marshall ^e   Jenkins, Judith M ^a   Norris, Patrick R ^a   Moore, Jason H ^c   Williams, Anna E ^a   McNew, Brent S ^a   Canter, Jeffrey A ^b  

^a Division of Trauma and Surgical Critical Care   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c Potentia Pharmaceuticals   (United States)

^d DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^e Dartmouth Hitchcock Medical Center ^*

Author keywords

Classical complement pathway; Genetic variation; Infection; Mortality; Trauma

Indexed keywords

COMPLEMENT COMPONENT C2; DNA; LACTIC ACID;

ADULT; AFRICAN AMERICAN; AGE DISTRIBUTION; ARTICLE; ASIAN; BLUNT TRAUMA; COHORT ANALYSIS; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; COMPLEMENT CLASSICAL PATHWAY; CONTROLLED STUDY; DEATH; DISEASE ACTIVITY; DNA DETERMINATION; ETHNICITY; EUROPEAN AMERICAN; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HISPANIC; HOSPITAL ADMISSION; HUMAN; INJURY; INJURY SCALE; INJURY SEVERITY; LACTATE BLOOD LEVEL; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; OUTCOME ASSESSMENT; PENETRATING TRAUMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE; SCORING SYSTEM; SEX RATIO; SINGLE NUCLEOTIDE POLYMORPHISM; STRATIFICATION; VALIDATION PROCESS; VENTILATOR ASSOCIATED PNEUMONIA; ANALYSIS OF VARIANCE; CAUSE OF DEATH; CROSS INFECTION; EMERGENCY HEALTH SERVICE; GENETIC PREDISPOSITION; GENETICS; INCIDENCE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; RISK; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; UNIVERSITY HOSPITAL;

ADULT; AGE DISTRIBUTION; ANALYSIS OF VARIANCE; CAUSE OF DEATH; COHORT STUDIES; COMPLEMENT C2; COMPLEMENT PATHWAY, CLASSICAL; CROSS INFECTION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HOSPITAL MORTALITY; HOSPITALS, UNIVERSITY; HUMANS; INCIDENCE; INJURY SEVERITY SCORE; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PNEUMONIA, VENTILATOR-ASSOCIATED; PROGNOSIS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEX DISTRIBUTION; TRAUMA CENTERS; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 67649669906     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31819ea61a     Document Type: Article

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