Maximum Tolerated Dose and Early Response - Results of a Phase I Trial of Paclitaxel and Cisplatin with Radiation Therapy in Carcinoma of the Cervix1

Clinical Oncology

Volumn 21, Issue 6, 2009, Pages 488-493

  Prasad, E ^a   Viswanathan, P N ^a   Rangad, V F ^a   Pavamani, S ^a   Ram, T S ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Cisplatin; maximum tolerated dose (MTD); paclitaxel; phase I; uterine cervical neoplasm

Indexed keywords

CISPLATIN; PACLITAXEL;

ABDOMINAL PAIN; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CELL COUNT; BRACHYTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CREATININE BLOOD LEVEL; CYSTITIS; DERMATITIS; DIARRHEA; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; ENTERITIS; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; MULTIPLE CYCLE TREATMENT; NEUTROPHIL COUNT; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROCTITIS; RADIATION DERMATITIS; SIDE EFFECT; THROMBOCYTE COUNT; UTERINE CERVIX CARCINOMA; VAGINAL DRYNESS; VAGINITIS; WEIGHT REDUCTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRACHYTHERAPY; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MAXIMUM TOLERATED DOSE; PACLITAXEL; RADIOTHERAPY; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 67649659708     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2009.03.002     Document Type: Article

References (19)

1. Perez C., Breaux S., and Madoc-Jones H. Radiotherapy alone in the treatment of carcinoma of the cervix: analysis of tumor recurrence. Cancer 51 (1983) 1393-1402
2. Perez C.A., Grisby P.W., Chao K.S., Mutch D.J., and Lockett M.A. Tumor size, irradiation dose, and long-term outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys 41 2 (1998) 307-317
3. Lukka H., Hirte H., Thomas G., et al. Cancer Care Ontario Practice Guidelines Initiative Gynecology Disease Site Group. Concurrent cisplatin based chemotherapy plus radiotherapy for cervical cancer - a meta-analysis. Clin Oncol 14 (2002) 203-212
4. Green J.A., Kirwan J.M., and Tierney J.F. A systematic review and meta analysis of randomized trials of concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: better survival and reduced distant recurrence rate. Lancet 358 (2001) 781-786
5. Cerciello F., Hofstetter B., Fatah S.A., et al. G2/M cell check point is functional in cervical cancer patients after initiation of external beam radiotherapy. Int J Radiat Oncol Biol Phys 62 5 (2005) 1390-1398
6. Rodriguez M., Sevin B.-U., Perras J., Nguyen H.N., Pham C., and Steren A.J. Paclitaxel: a radiation sensitizer of human cervical cancer cell lines. Gynecol Oncol 57 (1995) 165-169
7. Britten R.A., Pedue S., Opoku J., and Craighead P. Paclitaxel is preferentially cytotoxic to human cervical tumor cell lines with low Raf-1 kinase activity: implications of paclitaxel based chemoradiation regimes. Radiother Oncol 48 3 (1998) 329-334
8. Minarik L., and Eric J.H. Taxol in combination with acute and low dose rate irradiation. Radiother Oncol 32 2 (1994) 124-128
9. Chen D.M., Paley P.J., Potish R.A., and Twiggs L.B. Phase I trial of Taxol as a radiation sensitizer with cisplatin in advanced cervical cancer. Gynecol Oncol 67 2 (1997) 131-136
10. Pignata S., Frezza P., Tramontana S., et al. Phase I study with weekly cisplatin-paclitaxel and concurrent radiotherapy in patients with carcinoma of the cervix uteri. Ann Oncol 11 (2000) 455-459
11. Miglietta L., Franzone P., Centuroni M.G., et al. Phase II trial with cisplatin-paclitaxel cytotoxic treatment and concurrent external and endocavitary radiation therapy in locally advanced or recurrent cervical cancer. Oncology 70 1 (2006) 19-24
12. DiSelvestro A.P., Walker L.J., Morrison A., Rose P.G., Homesley H., and Warshal D. Radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in cervical carcinoma limited to pelvis: a phase I/II study of the Gynecologic Oncology group. Gynecol Oncol 103 (2006) 1038-1042
13. Tierney J.F., Vale C., and Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer. Clin Oncol 20 6 (2008) 401-416
14. Cerrotta A., Garden G., Cavina R., et al. Concurrent radiotherapy and weekly paclitaxel for locally advanced and recurrent squamous cell carcinoma of the uterine cervix. A pilot study with intensification of the dose. Eur J Gynaecol Oncol 23 2 (2002) 115-119
15. Seoud M.A.-F., Shaseddine, Ali, et al. Randomized trial comparing concurrent radiotherapy with cisplatin compared with paclitaxel in cervical cancer. Obstet Gynecol 107 4 (2006) 43s
16. Pearcey R., Brundage M., Droin J., et al. Phase III trial of comparing radical radiation therapy and cisplatin in patients with advanced squamous cell carcinoma of the cervix. J Clin Oncol 20 (2002) 966-972
17. Rose P.G., Bundy B.N., Watkins E.B.J., et al. Concurrent cisplatin based chemotherapy plus radiotherapy for locally advanced cervical cancer. N Engl J Med 340 15 (1999) 1147-1153
18. Morris M., Eifel P.J., Lu J., et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para aortic radiation in high risk cervical cancer. N Engl J Med 340 (1999) 1137-1143
19. Kirwan J., Symonds P., and Green J.A. A systematic review of acute and late toxicity of concurrent chemoradiation for cervical cancer (Review). Radiother Oncol 68 (2003) 217-226