A high percentage of skin melanoma cells expresses SPANX proteins

American Journal of Dermatopathology

Volumn 31, Issue 2, 2009, Pages 182-186

  Salemi, Michele ^a,b   Calogero, Aldo E ^a   Vicari, Enzo ^a   Migliore, Eleonora ^b   Zaccarello, Gianluca ^b   Cosentino, Anna ^c   Amore, Mario ^c   Tricoli, Dario ^c   Castiglione, Roberto ^b   Bosco, Paolo ^a   Rappazzo, Giancarlo ^b  

^a OASI RESEARCH INSTITUTE IRCCS   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c Gravina Hospital   (Italy)

Author keywords

Melanoma; Polyclonal antibody; Protein expression; SPANX genes

Indexed keywords

TUMOR MARKER; ANTIBODY; EPITOPE; NUCLEAR PROTEIN; SPANXA1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CHROMOSOME XQ; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MELANOMA CELL; MICROSCOPY; NEVUS; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; SPANX GENE; TISSUE SECTION; ANIMAL; ANTIBODY SPECIFICITY; BIOPSY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MOUSE; MULTIGENE FAMILY; NEOPLASM; PATHOLOGY; PHYSIOLOGY; SKIN; SKIN TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; BIOPSY; EPITOPES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MICE; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASMS; NEVUS; NUCLEAR PROTEINS; SKIN; SKIN NEOPLASMS;

EID: 67649654274     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181978d6f     Document Type: Article

References (25)

1. de Vries E, Coebergh JW. Melanoma incidence has risen in Europe. BMJ. 2005;24:331.
2. Tumino R, Frasca G, Palli D, et al. Cancer incidence in EPIC-ITALY at first follow-up. Tumori. 2003;89:656.
3. Bailey JA, Gu Z, Clark RA, et al. Recent segmental duplications in the human genome. Science. 2002;297:1003.
4. Cheung J, Estivill X, Khaja R, et al. Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence. Genome Biol. 2003;4:25.
5. Salemi M, Calogero AE, Di Benedetto D, et al. Expression of SPANX proteins in human-ejaculated spermatozoa and sperm precursors. Int J Androl. 2004;27:13.
6. Salemi M, Calogero AE, Bosco P, et al. Expression of SpanX proteins in normal testes and in testicular germ cell tumours. Int J Androl. 2006; 29:368.
7. Salemi M, Calogero AE, Bosco P, et al. Expression of SpanX mRNA in testicular germ cell tumors. Hum Cell. 2006;19:87.
8. Kouprina N, Mullokandov M, Rogozin IB, et al. The SPANX gene family of cancer/testis-specific antigens: rapid evolution, an unusual case of positive selection and amplification in African great apes and hominids. Proc Natl Acad Sci U S A. 2004;101:3077.
9. Westbrook VA, Diekman AB, Klotz KL, et al. Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. Biol Reprod. 2000;63:469.
10. Zendman AJ, Zschocke J, van Kraats AA, et al. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. Gene. 2003;309:125.
11. Westbrook VA, Schoppee PD, Vanage GR, et al. Genomic organization, incidence, and localization of the SPAN-X family of cancer-testis antigens in melanoma tumors and cell lines. Clin Cancer Res. 2004;10:101.
12. Wang Z, Zhang Y, Liu H, et al. Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies. Blood. 2003;101:955.
13. Zendman AJ, Cornelissen IM, Weidle UH, et al. CTp11, a novel member of the family of human cancer/testis antigens. Cancer Res. 1999; 59:6223.
14. M. Salemi, P. Bosco, F. CalI, et al. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. Melanoma Res. 2008;18:295.
15. Kouprina N, Pavlicek A, Noskov VN, et al. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. Genome Res. 2005;15:1477.
16. Nagasaki K, Manabe T, Hanzawa H, et al. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. Cancer Lett. 1999;140:227.
17. Chen YT, Güre AO, Tsang S, et al. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci U S A. 1998;95:6919.
18. Lucas S, De Plaen E, Boon T. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. Int J Cancer. 2000;87:55.
19. Collignon J, Sockanathan S, Hacker A, et al. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996;122:509.
20. Salemi M, Romano C, Ragusa L, et al. A new 6-bp SOX3 polyalanine tract deletion does not segregate with mental retardation. Genet Test. 2007;11:124.
21. Laumonnier F, Ronce N, Hamel BC, et al. Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency. Am J Hum Genet 2002;71:1450.
22. Chen YT, Rettig WJ, Yenamandra AK, et al. Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. Proc Natl Acad Sci U S A. 1990; 87:3077.
23. Dropcho EJ, Chen YT, Posner JB, et al. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Nat Acad Sci U S A. 1987;84:4552.
24. Furneaux HM, Rosenblum MK, Dalmau J, et al. Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med. 1990;322:1844.
25. Shaw CJ, Lupski JR. Implications of human genome architecture for rearrangement-based disorders: the genomic basis of disease. Hum Mol Genet. 2004;1:57.