Cardiomyopathies: The fatty hearts of patients with diabetes

Nature Reviews Cardiology

Volumn 6, Issue 4, 2009, Pages 268-269

  Lingvay, Ildiko ^a   Raskin, Philip ^a   Szczepaniak, Lidia S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL; BIOLOGICAL MARKER;

CARDIOMYOPATHY; DIABETES MELLITUS; DIASTOLIC DYSFUNCTION; HUMAN; LIPID METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SHORT SURVEY; STEATOSIS; TISSUE LEVEL; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; PROGNOSIS;

BIOLOGICAL MARKERS; CARDIOMYOPATHIES; DIABETES MELLITUS, TYPE 2; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TRIGLYCERIDES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 67649652167     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2009.30     Document Type: Short Survey

References (9)

1. Aneja, A., Tang, w. H., Bansilal, s., Garcia, M. J. & Farkouh, M. e. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am. J.Med. 121, 748-757 (2008).
2. szczepaniak, L. s., victor, R. G., Orci, L. & Unger, R. H. Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ. Res. 101, 759-767 (2007).
3. sharma, s. et al. intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J. 18, 1692-1700 (2004).
4. Rijzewijk, L. J. et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J. Am. Coll. Cardiol. 52, 1793-1799 (2008).
5. schick, F. et al. Comparison of localized proton nMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn. Reson. Med. 29, 158-167 (1993).
6. van der Meer, R. w. et al. Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. Radiology 245, 251-257 (2007).
7. szczepaniak, L. s. et al. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn. Reson. Med. 49, 417-423 (2003).
8. McGavock, J. M. et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 116, 1170-1175 (2007).
9. Lindsey, J. B. & Marso, s. P. steatosis and diastolic dysfunction: the skinny on myocardial fat. J. Am. Coll. Cardiol. 52, 1800-1802 (2008).