Highly sensitive method for the determination of ropinirole with a lower limit of quantitation of 3.45 pg/mL in human plasma by LC-ESI-MS/MS: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 23, Issue 5, 2009, Pages 557-562

  Bharathi, D Vijaya ^a,b   Jagadeesh, B ^a   Kumar, S Sirish ^a   Lakshmi, Revathi Naga ^a   Hotha, Kishore Kumar ^a   Naidu, A ^b   Mullangi, Ramesh ^a,c  

^a DR REDDY'S LABORATORIES LTD   (India)

^b JNTUH COLLEGE OF ENGINEERING   (India)

^c Jubilant Innovation   (India)

Author keywords

Human plasma; LC MS MS; Method validation; Pharmacokinetics; Ropinirole

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); POSITIVE IONS;

HUMAN PLASMAS; INTERNAL STANDARDS; LC-ESI-MS/MS; LC-MS-MS; LC.MS/MS; LOWER LIMITS OF QUANTITATIONS; METHOD VALIDATIONS; PHARMACOKINETIC STUDIES; ROPINIROLE; SENSITIVE METHOD;

ELECTROSPRAY IONIZATION;

ACETONITRILE; AMMONIA; CITALOPRAM; ROPINIROLE; DOPAMINE RECEPTOR STIMULATING AGENT; INDOLE DERIVATIVE;

ACCURACY; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHASE TRANSITION; POSITIVE ION ELECTROSPRAY; PROCESS TECHNOLOGY; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; BLOOD; ECONOMICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TIME; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE AGONISTS; HUMANS; INDOLES; MALE; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 67649643754     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1144     Document Type: Article

References (7)

1. Bhatt J, Jangid A, Shetty R, Shah B, Kambli S, Subbaiah G and Singh S. Rapid and sensitive liquid chromatography-mass spectrometry method for determination of ropinirole in human plasma. Journal of Pharmaceutical and Biomedical Analysis 2006; 40: 1202-1208.
2. Dams R, Huestis MA, Lambert WE and Murphy CM. Matrix effect in bioanalysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. Journal of American Society for Mass Spectrometry 2003; 14: 1290-1294.
3. Hubert Ph, Chiap P, Crommen J, Boulanger B, Chapuzet E, Mercier N, Bervoas-Martin S, Chevalier P, Grandjean D, Lagorce P, Lallier M, Laparra MC, Laurentie M and Nivet JC. The SFSTP guide on the validation of chromatographic methods for drug bioanalysis Washington confŗence to the laboratory. Analytica Chimica Acta 1999; 391: 135-148.
4. Kaye CM and Nicholls B. Clinical pharmacokinetics of ropinirole. Clinical Pharmacokinetics 2000; 39: 243-254.
5. Matheson AJ and Spencer CM. Ropinirole: a review of its use in the management of Parkinson's disease. Drugs 2000; 60: 115-137.
6. US DHHS, FDA, CDER. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, 2001. Available at: http://www/fda.gov/cder/ guidance/index.htm
7. Wen AD, Jia YY, Luo XX, Bi LL, Chen XY and Zhong DF. The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers. Journal of Pharmaceutical and Biomedical Analysis 2007; 43: 774-778.