Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes

Journal of Dermatological Science

Volumn 55, Issue 2, 2009, Pages 134-136

  Isaeva, Antonia Rumenova ^a   Mitev, Vanyo Ivanov ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; DNA; MYC PROTEIN; PROTEIN P21; TRANSCRIPTION FACTOR E2F1;

CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL TRANSPORT; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; LETTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; CASEIN KINASE II; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; E2F1 TRANSCRIPTION FACTOR; EPIDERMIS; HUMANS; KERATINOCYTES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; TRIAZOLES;

EID: 67649635052     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2009.04.001     Document Type: Letter

References (10)

1. Maggio F., and Pinna L. One-thousand-and-one substrates of protein kinase CK2?. FASEB J 17 (2003) 349 368
2. DeGregori J., and Johnson D. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6 (2006) 739 748
3. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 12 (1998) 2245 2262
4. Ivanova I., Vespa A., and Dagnino L. A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling. Determinants of nuclear import and export. Cell Cycle 6 (2007) 2186 2195
5. O'Donnell K., Wentzel E., Zeller K., Dang C., and Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435 (2005) 839843
6. Henriksson M., and Lüscher B. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 68 (1996) 109 182
7. Waf1/Cip1. Oncogene 18 (1999) 381 5392
8. Ivanova I., and Dagnino L. Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation. Oncogene 26 (2007) 1147 1154
9. Isaeva A., Atanasova G., and Mitev V. Inhibition of CK2 activity provokes opposite effects on ERK1/2 phosphorylation and p38 MAPK phosphorylation in normal human keratinocytes. Compt Rend Acad Bulg Sci 60 (2007) 909 912
10. WAF1/CIP1 is phosphorylated by protein kinase CK2 in vitro and interacts with the amino terminal end of the CK2 beta subunit. J Cell Biochem 81 (2001) 445 452