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1
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0034600451
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Control of sexually transmitted diseases for HIV-1 prevention: Understanding the implications of the Mwanza and Rakai trials
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Grosskurth H, Gray R, Hayes R, et al. Control of sexually transmitted diseases for HIV-1 prevention: understanding the implications of the Mwanza and Rakai trials. The Lancet 2003; 355:1981-1987.
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The Lancet
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Grosskurth, H.1
Gray, R.2
Hayes, R.3
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2
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43149125179
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Male circumcision for HIV prevention: From evidence to action?
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With the first biomedical preventive intervention now proven, this paper maps the long road ahead to implementation
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Weiss HA, Halperin D, Bailey RC, et al. Male circumcision for HIV prevention: from evidence to action? AIDS 2008; 22:567-574. With the first biomedical preventive intervention now proven, this paper maps the long road ahead to implementation.
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AIDS
, vol.22
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Weiss, H.A.1
Halperin, D.2
Bailey, R.C.3
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3
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67649608847
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Vaccine Trial Network. Vaccination and enrollment are discontinued in phase II trials of Merck's investigational HIV vaccine candidate
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21 September 2007, Accessed 15 April 2008
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Merck, HIV Vaccine Trial Network. Vaccination and enrollment are discontinued in phase II trials of Merck's investigational HIV vaccine candidate. Interim analysis of STEP study shows vaccine was not effective; 21 September 2007. http://www.hivvaccineenterprise.org/-dwn/news/FINAL-HIV-Vaccine- Press-Release.pdf. [Accessed 15 April 2008]
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Interim analysis of STEP study shows vaccine was not effective
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Merck, H.I.V.1
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5
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42349092765
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Council P, is safe, but does not prove it effective; 18 February 2008, Accessed 15 April 2008
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Council P. Trial shows anti-HIV microbicide is safe, but does not prove it effective; 18 February 2008. http://www.popcouncil.org/mediacenter/ newsreleases/Carraguard-Findings.html. [Accessed 15 April 2008]
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Trial shows anti-HIV microbicide
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6
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67651143254
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Effectiveness of cellulose sulfate gel for prevention of HIV: Results of the phase III trial in Nigeria [abstract]
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22-25 July, Sydney. Geneva: IAS;, Abstract WESS302
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Halpern V, Wang L, Obunge O, et al. Effectiveness of cellulose sulfate gel for prevention of HIV: results of the phase III trial in Nigeria [abstract]. In: Proceedings of the Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention; 22-25 July 2007; Sydney. Geneva: IAS; 2007. Abstract WESS302.
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Proceedings of the Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention
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Halpern, V.1
Wang, L.2
Obunge, O.3
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7
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67649850671
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Phase III trial of 6% cellulose sulfate (CS) gel for the prevention of HIV transmission [abstract]
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22-25 July, Sydney. Geneva: IAS;, Abstract WESS301
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Van Damme L, Govinden R, Mirembe F, et al. Phase III trial of 6% cellulose sulfate (CS) gel for the prevention of HIV transmission [abstract]. In: Proceedings of the Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention; 22-25 July 2007; Sydney. Geneva: IAS; 2007. Abstract WESS301
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(2007)
Proceedings of the Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention
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Van Damme, L.1
Govinden, R.2
Mirembe, F.3
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8
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0036787314
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Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: Systematic review and meta-analysis of randomised controlled trials including more than 5000 women
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Wilkinson D, Tholandi M, Ramjee G, Rutherford GW. Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: systematic review and meta-analysis of randomised controlled trials including more than 5000 women. Lancet Infect Dis 2002; 2:613-617.
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Lancet Infect Dis
, vol.2
, pp. 613-617
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Wilkinson, D.1
Tholandi, M.2
Ramjee, G.3
Rutherford, G.W.4
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9
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34447527138
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Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: A randomised controlled trial
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This describes a long awaited and important trial that was ultimately disappointing but has led to many lessons for the prevention field
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Padian N, van der Straten A, Ramjee G, et al. Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial. The Lancet 2007; 370:251-261. This describes a long awaited and important trial that was ultimately disappointing but has led to many lessons for the prevention field.
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(2007)
The Lancet
, vol.370
, pp. 251-261
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Padian, N.1
van der Straten, A.2
Ramjee, G.3
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10
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42349083085
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HSV-2 suppressive therapy for prevention of HIV acquisition: Results of HPTN 039 [abstract]
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3-6 February, Boston. Alexandria: CROI, Paper 32
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Celum C, Wald A, Hughes J, et al. HSV-2 suppressive therapy for prevention of HIV acquisition: results of HPTN 039 [abstract]. In: 15th Conference on Retroviruses and Opportunistic Infections; 3-6 February 2008; Boston. Alexandria: CROI 2008. Paper 32.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Celum, C.1
Wald, A.2
Hughes, J.3
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11
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34249825779
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Peterson L, Taylor D, Roddy R, et al. Tenofovir disoproxil fumarate for prevention of hiv infection in women: a phase 2, double-blind, randomized, placebo-controlled trial. PLoS Clinical Trials 2007; 2:1-9. This is the first publication of a trial of chemoprophylaxis against HIV infection. Unfortunately the study was vastly underpowered after the closure of other sites that were supposed to ensure adequate sample size.
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Peterson L, Taylor D, Roddy R, et al. Tenofovir disoproxil fumarate for prevention of hiv infection in women: a phase 2, double-blind, randomized, placebo-controlled trial. PLoS Clinical Trials 2007; 2:1-9. This is the first publication of a trial of chemoprophylaxis against HIV infection. Unfortunately the study was vastly underpowered after the closure of other sites that were supposed to ensure adequate sample size.
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12
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33847390394
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Microbicide drug candidates to prevent HIV infection
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This is a comprehensive review of microbicide development from two leaders in the field
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Balzarini J, Van Damme L. Microbicide drug candidates to prevent HIV infection. The Lancet 2007; 369:787-797. This is a comprehensive review of microbicide development from two leaders in the field.
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(2007)
The Lancet
, vol.369
, pp. 787-797
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Balzarini, J.1
Van Damme, L.2
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13
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42049084625
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Challenges to HIV prevention: Seeking effective measures in the absence of a vaccine
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Lagakos SW, Gable AR. Challenges to HIV prevention: seeking effective measures in the absence of a vaccine. N Engl J Med 2008; 358:1543-1545.
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(2008)
N Engl J Med
, vol.358
, pp. 1543-1545
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Lagakos, S.W.1
Gable, A.R.2
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14
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29744459673
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Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection
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Dhawan D, Mayer KH. Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection. J Infect Dis 2006; 193:36-44.
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(2006)
J Infect Dis
, vol.193
, pp. 36-44
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Dhawan, D.1
Mayer, K.H.2
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15
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20944437246
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HIV sexual risk behavior over 36 months of follow-up in the world's first HIV vaccine efficacy trial
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for the VISION/VAX004 Study Team
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Bartholow BN, Buchbinder S, Celum C, et al., for the VISION/VAX004 Study Team. HIV sexual risk behavior over 36 months of follow-up in the world's first HIV vaccine efficacy trial. JAIDS 2005; 39:90-101.
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(2005)
JAIDS
, vol.39
, pp. 90-101
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Bartholow, B.N.1
Buchbinder, S.2
Celum, C.3
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16
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33845997802
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Male circumcision in Siaya and Bondo Districts, Kenya: Prospective cohort study to assess behavioral disinhibition following circumcision
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Agot KE, Kiarie JN, Nguyen HQ, et al. Male circumcision in Siaya and Bondo Districts, Kenya: prospective cohort study to assess behavioral disinhibition following circumcision. J Acquir Immune Defic Syndr 2007; 1:66-70.
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(2007)
J Acquir Immune Defic Syndr
, vol.1
, pp. 66-70
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Agot, K.E.1
Kiarie, J.N.2
Nguyen, H.Q.3
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17
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3042674950
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Public health: Regulatory challenges in microbicide development
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Coplan PM, Mitchnick M, Rosenberg ZF. Public health: regulatory challenges in microbicide development. Science 2004; 304:1911-1912.
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(2004)
Science
, vol.304
, pp. 1911-1912
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Coplan, P.M.1
Mitchnick, M.2
Rosenberg, Z.F.3
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18
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3943051978
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Some design issues in trials of microbicides for the prevention of HIV infection
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Fleming TR, Richardson BA. Some design issues in trials of microbicides for the prevention of HIV infection. J Infect Dis 2004; 190:666-674.
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(2004)
J Infect Dis
, vol.190
, pp. 666-674
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Fleming, T.R.1
Richardson, B.A.2
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19
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67649597163
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Fleming TR, Richardson BA. Reply to Skoler et al. and to Stein and Susser. J Infect Dis 2005; 191:1378-1379.
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Fleming TR, Richardson BA. Reply to Skoler et al. and to Stein and Susser. J Infect Dis 2005; 191:1378-1379.
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20
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17044411185
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Control groups in microbicide trials: In defense of orthodoxy
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Stein ZA, Susser MW. Control groups in microbicide trials: in defense of orthodoxy. J Infect Dis 2005; 191:1377-1378.
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(2005)
J Infect Dis
, vol.191
, pp. 1377-1378
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Stein, Z.A.1
Susser, M.W.2
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21
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0037980414
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Shifts in condom use following microbicide introduction: Should we be concerned?
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Foss AM, Vickerman PT, Heise L, Watts CH. Shifts in condom use following microbicide introduction: should we be concerned? AIDS 2003; 17:1227-1237.
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(2003)
AIDS
, vol.17
, pp. 1227-1237
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Foss, A.M.1
Vickerman, P.T.2
Heise, L.3
Watts, C.H.4
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22
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34147121381
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Male circumcision to prevent HIV transmission and acquisition: What else do we need to know?
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Muula AS. Male circumcision to prevent HIV transmission and acquisition: what else do we need to know? AIDS Behav 2007; 11:357-363.
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(2007)
AIDS Behav
, vol.11
, pp. 357-363
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Muula, A.S.1
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23
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Module three: Vulnerable/special participant populations
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Lott JP. Module three: Vulnerable/special participant populations. Developing World Bioethics 2005; 5:30-54.
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(2005)
Developing World Bioethics
, vol.5
, pp. 30-54
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Lott, J.P.1
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26
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33847014565
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Karita E, Price M, Hunter E, et al. Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa. AIDS 2007; 21:403-408. The authors assess the validity of the most widely used HIV incidence assay, which has been criticized for potentially overestimating in the African context.
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Karita E, Price M, Hunter E, et al. Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa. AIDS 2007; 21:403-408. The authors assess the validity of the most widely used HIV incidence assay, which has been criticized for potentially overestimating in the African context.
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27
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33846195892
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Comparison of HIV type 1 incidence observed during longitudinal follow-up with incidence estimated by cross-sectional analysis using the BED capture enzyme immunoassay
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McDougal J, Parekh BS, Peterson ML, et al. Comparison of HIV type 1 incidence observed during longitudinal follow-up with incidence estimated by cross-sectional analysis using the BED capture enzyme immunoassay. AIDS Res Hum Retroviruses 2006; 22:945-952.
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(2006)
AIDS Res Hum Retroviruses
, vol.22
, pp. 945-952
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McDougal, J.1
Parekh, B.S.2
Peterson, M.L.3
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28
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0003433351
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Geneva: Council for International Organizations of Medical Sciences;, Accessed 7 March 2006
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Council for International Organizations of Medical Sciences. International ethical guidelines for biomedical research involving human subjects. Geneva: Council for International Organizations of Medical Sciences; 2002. www. cioms.ch/guidelines-nov-2002-blurb.htm. [Accessed 7 March 2006]
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(2002)
International ethical guidelines for biomedical research involving human subjects
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30
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33746441994
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Forbes A. Moving toward assured access to treatment in microbicide trials. PLoS Medicine 2006; 3:980-983.
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Forbes A. Moving toward assured access to treatment in microbicide trials. PLoS Medicine 2006; 3:980-983.
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31
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26944478567
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HIV prevention research in a resource-limited setting: The experience of planning a trial in Cambodia
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Page-Shafer K, Saphonn V, Sun L, et al. HIV prevention research in a resource-limited setting: the experience of planning a trial in Cambodia. Lancet 2005; 366:1499-1503.
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(2005)
Lancet
, vol.366
, pp. 1499-1503
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Page-Shafer, K.1
Saphonn, V.2
Sun, L.3
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32
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8744241604
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Standard of care should reflect local conditions and not the best western standards
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Bhutta Z. Standard of care should reflect local conditions and not the best western standards. BMJ 2004; 329:1114-1115.
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(2004)
BMJ
, vol.329
, pp. 1114-1115
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Bhutta, Z.1
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33
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33645804375
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Regulation of biomedical research in Africa
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Chima SC. Regulation of biomedical research in Africa. BMJ 2006; 332:848-851.
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(2006)
BMJ
, vol.332
, pp. 848-851
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Chima, S.C.1
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34
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15744397587
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The trials of tenofovir trials
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Anonymous
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Anonymous. The trials of tenofovir trials. Lancet 2005; 365:1111.
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Lancet
, vol.365
, pp. 1111
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35
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33947631339
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Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa
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Nagelkerke NJ, Moses S, de Vlas SJ, Bailey RC. Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis 2007; 13:16.
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(2007)
BMC Infect Dis
, vol.13
, pp. 16
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Nagelkerke, N.J.1
Moses, S.2
de Vlas, S.J.3
Bailey, R.C.4
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38
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34147120529
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Acceptability of male circumcision for prevention of HIV/AIDS in Sub-Saharan Africa: A review
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This presents critical assessment of acceptability studies of male circumcision that tells us that the intervention is generally acceptable
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Westercamp N, Bailey RC. Acceptability of male circumcision for prevention of HIV/AIDS in Sub-Saharan Africa: a review. AIDS Behav 2007; 11:341-355. This presents critical assessment of acceptability studies of male circumcision that tells us that the intervention is generally acceptable.
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(2007)
AIDS Behav
, vol.11
, pp. 341-355
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Westercamp, N.1
Bailey, R.C.2
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39
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7544222644
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Microbicide acceptability research: Current approaches and future directions
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Mantell JE, Myer L, Carballo-Diéguez A, et al. Microbicide acceptability research: current approaches and future directions. Soc Sci Med 2005; 2:19-30.
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(2005)
Soc Sci Med
, vol.2
, pp. 19-30
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Mantell, J.E.1
Myer, L.2
Carballo-Diéguez, A.3
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40
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34547571735
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Ramjee G, Govinden R, Morar NS, Mbewu A. South Africa's experience of the closure of the cellulose sulphate microbicide trial. PLoS Medicine 2007; 4:1167-1173. An issue of increasing importance: what happens on the ground when a trial is stopped ahead of the planned completion date?
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Ramjee G, Govinden R, Morar NS, Mbewu A. South Africa's experience of the closure of the cellulose sulphate microbicide trial. PLoS Medicine 2007; 4:1167-1173. An issue of increasing importance: what happens on the ground when a trial is stopped ahead of the planned completion date?
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41
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15744401962
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Listening to consumers and HIV vaccine preparedness
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Duran N. Listening to consumers and HIV vaccine preparedness. Lancet 2005; 365:1119-1121.
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(2005)
Lancet
, vol.365
, pp. 1119-1121
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Duran, N.1
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