Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis

Parasitology Research

Volumn 105, Issue 1, 2009, Pages 155-162

  Mateo, Marta ^a   Maynard, Laurence ^b   Vischer, Claudia ^b   Bianciardi, Paolo ^c   Miró, Guadalupe ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Virbac SA   (France)

^c NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MEGLUMINE; MEGLUMINE ANTIMONATE; MILTEFORAN; MILTEFOSINE; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW BIOPSY; DOG; DRUG EFFICACY; LEISHMANIASIS; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIPROTOZOAL AGENTS; BONE MARROW; DOG DISEASES; DOGS; FEMALE; INJECTIONS, SUBCUTANEOUS; LEISHMANIASIS; MALE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLCHOLINE;

CANIS FAMILIARIS;

EID: 67649610411     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-009-1375-3     Document Type: Article

References (37)

1. J Alvar C Cañavate M Molina J Moreno J Nieto 2004 Canine leishmaniasis Adv Parasitol 57 1 88 (Pubitemid 39422432)
2. Baneth G (2006) Leishmaniases. In: Green CE (ed) Infectious disease of the dog and cat. Elsevier, St Louis, Missouri, pp 685-696
3. G Baneth SE Shaw 2002 Chemotherapy of canine leishmaniosis Vet Parasitol 106 315 324 (Pubitemid 34655456)
4. SK Bhattacharya TK Jha S Sundar CP Thakur J Engel H Sindermann K Junge J Karbwang AD Bryceson JD Berman 2004 Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India Clin Infect Dis 38 2 217 221 (Pubitemid 38113029)
5. G Bourdoiseau P Denerolle 2000 Traitement de la leishmaniose canine: actualités Revue Méd Vét 151 395 400
6. SL Croft K Seifert M Duchêne 2003 Antiprotozoal activities of phospholipids analogues Mol Biochem Parasitol 126 165 172
7. I Cruz C Cañavate JM Rubio MA Morales C Chicharro F Laguna M Jiménez-Mejías G Sirena S Videla J Alvar 2002 A nested polymerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus Trans R Soc Trop Med Hyg 96 1 185 189
8. P Denerolle 1996 Leishmaniose canine: difficultés du diagnostic et du traitement (125 cas) Prat Méd Chir Anim Comp 31 137 145
9. P Denerolle G Bourdoiseau 1999 Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases) J Vet Intern Med 13 413 415
10. YM Gomes M Paiva Cavalcanti RA Lira FG Abath LC Alves 2008 Diagnosis of canine visceral leishmaniasis: biotechnological advances Vet J 175 1 45 52
11. M Gramiccia L Gradoni S Orsini 1992 Decreased sensitivity to meglumine antimoniate (Glucantime®) of Leishmania infantum isolated from dogs after several courses of drug treatment Ann Trop Med Parasitol 86 613 620 (Pubitemid 23090621)
12. FA Ikeda-García RS Lopes FJ Marques VMF Lima CK Morinishi FL Bonello MF Zanette SHV Perri MM Feitosa 2007 Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate Vet Parasitol 143 254 259 (Pubitemid 46116806)
13. TK Jha S Sundar CP Thakur P Bachmann J Karbwang C Fischer A Voss J Berman 1999 Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis N Engl J Med 341 24 1795 1800
14. AF Koutinas MN Saridomichelakis ME Mylonakis L Leontides Z Polizopoulou C Billinis D Argyriadis N Diakou O Papadopoulos 2001 A randomised, blinded, placebo-controlled clinical trial with allopurinol in canine leishmaniosis Vet Parasitol 98 4 247 261 (Pubitemid 32553825)
15. F Liste M Gascon 1995 Allopurinol in the treatment of canine visceral leishmaniasis Vet Rec 137 23 24
16. Manna L, Viola E, Pavone LM, Staiano N, Gravino AE (2005) Leishmanicidal activity of miltefosine in acute renal failure of naturally infected dogs. Worldleish3, Palermo-Terrasini, Sicily, Italy, p 165
17. L Manna S Reale F Vitale E Picillo LM Pavone AE Gravino 2008 Real-time PCR assay in Leishmania-infected dogs treated with meglumine antimoniate and allopurinol The Veterinary Journal 177 279 282
18. Manna L, Vitale F, Reale S, Picillo E, Neglia G, Vescio F, Gravino AE (2008b) Study of efficacy of miltefosine and allopurinol in dogs with leishmaniosis. The Veterinary Journal, doi: 10.1016/j.tvjl.2008.08.009.
19. Miró G, Mateo M, Cruz I, Cañavate C, Nieto J, Montoya A, Galy S, Médaille C, Alvar J (2005) Miltefosine: a new treatment for canine leishmaniosis. Preliminary results. Worldleish3, Palermo-Terrasini, Sicily, Italy, p 175
20. G Miró L Cardoso MG Pennisi G Oliva G Baneth 2008 Canine leishmaniosis-new concepts and insights on an expanding zoonosis: part two Trends in Parasitology 738 331 337
21. G Miró G Oliva I Cruz C Cañavate M Mortarino C Vischer P Bianciardi 2008 Multi-centric and controlled clinical field study to evaluate the efficacy and safety of the combination of miltefosine and allopurinol in the treatment of canine leishmaniosis Veterinary Dermatology 19 Suppl. 1 7 8
22. MA Moreira MC Luvizotto JF García CE Corbett MD Laurenti 2007 Comparison of parasitological, immunological and molecular methods for the diagnosis of leishmaniosis in dogs with different clinical signs Vet Parasitol 145 245 252 (Pubitemid 46436353)
23. C Noli ST Auxilia 2005 Treatment of canine Old World visceral leishmaniasis: a systematic review Veterinary Dermatology 16 4 213 232 (Pubitemid 41265192)
24. G Oliva A Scalone V Foglia Manzillo M Gramiccia A Pagano T Di Muccio L Gradoni 2006 Incidence and time course of Leishmania infantum infections examined by parasitological, serologic, and Nested-PCR techniques in a cohort of naïve dogs exposed to three consecutive transmission seasons J Clin Microbiol 44 4 1318 1322
25. S Pasa S Ozensoy Toz H Voyvoda Y Ozbel 2005 Clinical and serological follow-up in dogs with visceral leishmaniosis treated with allopurinol and sodium stibogluconate Vet Parasitol 128 243 249 (Pubitemid 40312433)
26. MG Pennisi M De Majo M Masucci D Britti F Vitale R Del Maso 2005 Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin Vet Rec 156 11 346 349 (Pubitemid 40468021)
27. Pouyol O (2004) Leishmaniose: des consensus diagnostiques et thérapeutiques. La Dépêche Vétérinaire, no 830
28. C Riera JE Valladares M Gallego MJ Aisa S Castillejo R Fisa N Ribas J Carrio J Alberola M Arboix 1999 Serological and parasitological follow-up in dogs experimentally infected with Leishmania infantum and treated with meglumine antimoniate Vet Parasitol 84 1-2 33 47 (Pubitemid 29298175)
29. A Sainz S Delgado I Amusategui MA Tesouro P Carmenes 1996 Seroprevalence of canine ehrlichiosis in Castilla-León (North-West Spain) Prev Vet Med 29 1 7 (Pubitemid 126371150)
30. MN Saridomichelakis ME Mylonakis LS Leontides Billinis Ch AF Koutinas AD Galatos P Gouletsou A Diakou VI Kontos 2005 Periodic administration of allopurinol is not effective for the prevention of canine leishmaniosis (Leishmania infantum) in the endemic areas Vet Parasitol 130 199 205 (Pubitemid 40733654)
31. L Solano-Gallego C Riera X Roura L Iniesta M Gallego JE Valladares R Fisa S Castillejo J Alberola L Ferrer M Arboix M Portus 2001 Leishmania infantum-specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas. Evolution in the course of infection and after treatment Vet Parasitol 96 4 265 276 (Pubitemid 32232213)
32. L Solano-Gallego P Morell M Arboix J Alberola L Ferrer 2001 Prevalence of Leishmania infantum infections in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology J Clin Microbiol 39 560 563 (Pubitemid 32150817)
33. H Sindermann J Engel 2006 Development of miltefosine as on oral treatment for leismaniasis Trans R Soc Trop Med Hyg 100 S17 S20 (Pubitemid 44490164)
34. S Sundar F Rosenkaimer MK Makharia AK Goyal AK Mandal A Voss P Hilgard HW Murray 1998 Trial of oral miltefosine for visceral leishmaniasis Lancet 352 1821 1823 (Pubitemid 28550072)
35. S Sundar A Makharia DK More G Agrawal A Voss C Fischer P Bachmann HW Murray 2000 Short-course of oral miltefosine for treatment of visceral leishmaniasis Clin Infect Dis 31 4 1110 1113 (Pubitemid 32299377)
36. S Sundar TK Jha CP Thakur SK Bhattacharya M Rai 2006 Oral miltefosine for the treatment of Indian visceral leishmaniasis Trans R Soc Med Hyg 100 S26 33 (Pubitemid 44490165)
37. JE Valladares C Riera P Gonzalez-Ensenyat A Diez-Cascon G Ramos L Solano-Gallego M Gallego M Portus M Arboix J Alberola 2001 Long term improvement in the treatment of canine leishmaniosis using an antimony liposomal formulation Vet Parasitol 97 1 15 21 (Pubitemid 32406116)