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1
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48949097660
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Antiretroviral treatment of adult HIV infection: 2008 Recommendations of the International AIDS Society USA Panel
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This paper describes the latest set of guidelines for the management of ARV naive and experienced HIV infected patients
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Hammer SM, Eron JJ, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 Recommendations of the International AIDS Society USA Panel. JAMA 2008; 230:555-570. This paper describes the latest set of guidelines for the management of ARV naive and experienced HIV infected patients.
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(2008)
JAMA
, vol.230
, pp. 555-570
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Hammer, S.M.1
Eron, J.J.2
Reiss, P.3
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3
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67649612938
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Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
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U.S Department of Health and Human Services DHHS, 29 January
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U.S Department of Health and Human Services (DHHS). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents; 29 January 2008. This paper describes the newest set of guidelines for treating the ARV-experienced patient.
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(2008)
This paper describes the newest set of guidelines for treating the ARV-experienced patient
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4
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67649610524
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British HIV Association guidelines for the treatment of HIV-infected adults with antiretroviral therapy
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British HIV Association BHIVA, in press
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British HIV Association (BHIVA). British HIV Association guidelines for the treatment of HIV-infected adults with antiretroviral therapy. 2008 (in press).
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(2008)
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5
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33746576313
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Durable efficacy of tipranavir/ritonavir in combination with an optimized background of ARV for treatment-experienced HIV-1 infected patients: 48 week results of the randomized evaluation of strategic intervention in multidrug resistant patients with tipranavir (RESIST) clinical trials
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Hicks C, Cahn P, Cooper D, et al. Durable efficacy of tipranavir/ritonavir in combination with an optimized background of ARV for treatment-experienced HIV-1 infected patients: 48 week results of the randomized evaluation of strategic intervention in multidrug resistant patients with tipranavir (RESIST) clinical trials. Lancet 2006; 368:466-475.
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(2006)
Lancet
, vol.368
, pp. 466-475
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Hicks, C.1
Cahn, P.2
Cooper, D.3
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6
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34047207229
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Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
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This article describes the pivotal trials demonstrating the role of darunavir in the management of the treatment-experienced patient
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Clotet B, Bellos N, Molina JM, et al. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet 2007; 369:1169-1178. This article describes the pivotal trials demonstrating the role of darunavir in the management of the treatment-experienced patient.
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(2007)
Lancet
, vol.369
, pp. 1169-1178
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Clotet, B.1
Bellos, N.2
Molina, J.M.3
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7
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35448948367
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TORO: 96 week virologic and immunological response and safety evaluation of enfuvirtide with an optimized background of antiretrovirals
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This article describes the long-term follow-up for patients receiving enfuvirtide as part of salvage ARV therapy
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Reynes J, Arasteh K, Clotet B, et al. TORO: 96 week virologic and immunological response and safety evaluation of enfuvirtide with an optimized background of antiretrovirals. AIDS Patient Care STDS 2007; 21:533-543. This article describes the long-term follow-up for patients receiving enfuvirtide as part of salvage ARV therapy.
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(2007)
AIDS Patient Care STDS
, vol.21
, pp. 533-543
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Reynes, J.1
Arasteh, K.2
Clotet, B.3
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8
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34347327010
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
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This paper describes the first data demonstrating the role of etravirine in the treatment-experienced patient
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Madruga JV, Cahn P, Grinsztejn B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:29-38. This paper describes the first data demonstrating the role of etravirine in the treatment-experienced patient.
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(2007)
Lancet
, vol.370
, pp. 29-38
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Madruga, J.V.1
Cahn, P.2
Grinsztejn, B.3
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9
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34347354196
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
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This paper describes the first data demonstrating the role of etravirine in the treatment-experienced patient
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Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:39-48. This paper describes the first data demonstrating the role of etravirine in the treatment-experienced patient.
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(2007)
Lancet
, vol.370
, pp. 39-48
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Lazzarin, A.1
Campbell, T.2
Clotet, B.3
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10
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67649583392
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Trottier B, Johnson M, Katlama C, et al. Pooled 48-week analysis of DUET-1 and DUET-2: durable efficacy and safety results of etravirine TMC125; ETR- in treatment-experienced HIV-infected patients [abstract no. P167]. Presented at the 17th Annual Canadian Conference on HIV/AIDS Research; 24-27 April 2008; Montreal, Quebec.
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Trottier B, Johnson M, Katlama C, et al. Pooled 48-week analysis of DUET-1 and DUET-2: durable efficacy and safety results of etravirine (TMC125; ETR- in treatment-experienced HIV-infected patients [abstract no. P167]. Presented at the 17th Annual Canadian Conference on HIV/AIDS Research; 24-27 April 2008; Montreal, Quebec.
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11
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42549140294
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Impact of baseline NNRTI mutations on the virological response to TMC125 in the phase III clinical trials DUET-1 and DUET-2 [abstract no.32]
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Presented at the 12-16 June, Barbados, West Indies
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Vingerhoets J, Buelens A, Peeters A, et al. Impact of baseline NNRTI mutations on the virological response to TMC125 in the phase III clinical trials DUET-1 and DUET-2 [abstract no.32]. Presented at the XVI International HIV Drug Resistance Workshop: Basic Principles & Clinical Implications; 12-16 June 2007; Barbados, West Indies.
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(2007)
XVI International HIV Drug Resistance Workshop: Basic Principles & Clinical Implications
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Vingerhoets, J.1
Buelens, A.2
Peeters, A.3
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12
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33746966338
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Significant decrease in TMC125 exposures with co-administered with tipranavir boosted with ritonavir in healthy subjects
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abstract 583, Presented at the 5-8 February, Denver, Colorado
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Scholler M, Kraft M, Hoetelmans R, et al. Significant decrease in TMC125 exposures with co-administered with tipranavir boosted with ritonavir in healthy subjects [abstract 583]. Presented at the 13th Conference on Retroviruses and Opportunistic Infections; 5-8 February 2006; Denver, Colorado.
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(2006)
13th Conference on Retroviruses and Opportunistic Infections
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Scholler, M.1
Kraft, M.2
Hoetelmans, R.3
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13
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34347329093
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Efficacy and safety of darunavirritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
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Madruga JV, Berger D, McMurchie M, et al. Efficacy and safety of darunavirritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet 2007; 370:49-58.
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(2007)
Lancet
, vol.370
, pp. 49-58
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Madruga, J.V.1
Berger, D.2
McMurchie, M.3
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14
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35048859880
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Maraviroc is a slowly reversible antagonist at the human CCr5 in a CRE luciferase reporter gene assay
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abstract 504, Presented at the 5-8 February, Denver, Colorado
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Pullen S, Sale H, Napier C, et al. Maraviroc is a slowly reversible antagonist at the human CCr5 in a CRE luciferase reporter gene assay [abstract 504]. Presented at the 13th Conference on Retroviruses and Opportunistic Infections; 5-8 February 2006; Denver, Colorado.
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(2006)
13th Conference on Retroviruses and Opportunistic Infections
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Pullen, S.1
Sale, H.2
Napier, C.3
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15
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14844333093
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Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
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Moyle GJ, Wildfire A, Mandalia S, et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis 2005; 191:866-872.
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(2005)
J Infect Dis
, vol.191
, pp. 866-872
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Moyle, G.J.1
Wildfire, A.2
Mandalia, S.3
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16
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33750872090
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Co-receptor tropism in patients screening for ACTG 5211, a phase 2 study for vicriviroc, a CCR5 inhibitor
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abstract 655, Presented at the 5-8 February, Denver, Colorado
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Wilkin T, Su Z, Kuritzkes D, et al. Co-receptor tropism in patients screening for ACTG 5211, a phase 2 study for vicriviroc, a CCR5 inhibitor [abstract 655]. Presented at the 13th Conference on Retroviruses and Opportunistic Infections; 5-8 February 2006; Denver, Colorado.
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(2006)
13th Conference on Retroviruses and Opportunistic Infections
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Wilkin, T.1
Su, Z.2
Kuritzkes, D.3
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17
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67649628317
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Mayer H, can der Ryst E, Saag M, et al. Safety and efficacy of maraviroc (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretroviral- experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial [abstract THLB0215]. Presented at the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada.
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Mayer H, can der Ryst E, Saag M, et al. Safety and efficacy of maraviroc (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretroviral- experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial [abstract THLB0215]. Presented at the XVI International AIDS Conference; 13-18 August 2006; Toronto, Canada.
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18
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35048870707
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Efficacy and safety of maraivroc (MVC) in antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1
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for the Motivate study team, abstract H-718a, Presented at the September, Chicago, Illinois
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Lalezari J, Mayer H, for the Motivate study team. Efficacy and safety of maraivroc (MVC) in antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1 [abstract H-718a]. Presented at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; 17-20 September 2007; Chicago, Illinois.
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(2007)
47th Interscience Conference on Antimicrobial Agents and Chemotherapy; 17-20
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Lalezari, J.1
Mayer, H.2
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19
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55049103539
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Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT) in viraemic, antiretroviral treatment-experienced patients infected with CCR5-tropic (R5) HIV-1 in Europe, Australia and North America (MOTIVATE 2): 48-week results [abstract P4.1/06]
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Presented at the 24-27 October, Madrid, Spain
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Fatkenheuer G, Konourina I, NelsonM, et al. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT) in viraemic, antiretroviral treatment-experienced patients infected with CCR5-tropic (R5) HIV-1 in Europe, Australia and North America (MOTIVATE 2): 48-week results [abstract P4.1/06]. Presented at the 11th European AIDS Conference; 24-27 October 2007; Madrid, Spain.
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(2007)
11th European AIDS Conference
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Fatkenheuer, G.1
Konourina, I.2
NelsonM3
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20
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43749114431
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Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week combined analysis of the MOTIVATE studies
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abstract 792, Presented at the 3-6 February, Boston, Massachusetts
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Hardy D, Reynes J, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week combined analysis of the MOTIVATE studies [abstract 792]. Presented at the 15th Conference on Retroviruses and Opportunistic Infections; 3-6 February 2008; Boston, Massachusetts.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Hardy, D.1
Reynes, J.2
Konourina, I.3
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21
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35548993029
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ACTG 5211: Phase II study of the safety and efficacy of vicriviroc (VCV) in HIV-infected treatment-experienced subjects: 48-week results
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abstract TUAB102, Presented at the 22-25 July, Sydney, Australia
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Gulick R, Su Z, Flexner C, et al. ACTG 5211: phase II study of the safety and efficacy of vicriviroc (VCV) in HIV-infected treatment-experienced subjects: 48-week results [abstract TUAB102]. Presented at the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 22-25 July 2007; Sydney, Australia.
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(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
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Gulick, R.1
Su, Z.2
Flexner, C.3
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22
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52149101363
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Vicriviroc, a next generation CCR5 antagonist, exhibits potent, sustained suppression of viral replication in treatment-experienced adults: VICTOR-E1 48-week results
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abstract 39LB, Presented at the 3-6 February, Boston, Massachusetts
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Zingman B, Suleiman J, Dejesus E, et al. Vicriviroc, a next generation CCR5 antagonist, exhibits potent, sustained suppression of viral replication in treatment-experienced adults: VICTOR-E1 48-week results [abstract 39LB]. Presented at the 15th Conference on Retroviruses and Opportunistic Infections; 3-6 February 2008; Boston, Massachusetts.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Zingman, B.1
Suleiman, J.2
Dejesus, E.3
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23
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47949120697
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Raltegravir with optimized background therapy for resistant HIV-1 infection
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This article is the first description of the role of integrase inhibitors for the therapy of the treatment-experienced patient
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Steigbigel R, Cooper D, Kumar P, et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359:339-354. This article is the first description of the role of integrase inhibitors for the therapy of the treatment-experienced patient
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(2008)
N Engl J Med
, vol.359
, pp. 339-354
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Steigbigel, R.1
Cooper, D.2
Kumar, P.3
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24
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47949114939
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Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
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This article outlines the efficacy of raltegravir in various subpopulations of patients and outlines predictors of response
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Cooper D, Steigbigel R, Gatell J, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359:355-365. This article outlines the efficacy of raltegravir in various subpopulations of patients and outlines predictors of response.
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(2008)
N Engl J Med
, vol.359
, pp. 355-365
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Cooper, D.1
Steigbigel, R.2
Gatell, J.3
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25
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67649586507
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Resistance analysis of a phase 2 study of the integrase inhibitor elvitegravir (GS-9137)
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abstract no, 24-27 October, Madrid, Spain
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McColl D, Fransen S, Gupta S, et al. Resistance analysis of a phase 2 study of the integrase inhibitor elvitegravir (GS-9137) [abstract no. P7.1/03]. Presented at the 11th European AIDS Conference/EACS; 24-27 October 2007; Madrid, Spain.
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(2007)
P7.1/03]. Presented at the 11th European AIDS Conference/EACS
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McColl, D.1
Fransen, S.2
Gupta, S.3
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26
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55049114155
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The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable antiretroviral activity in treatment-experienced patients with active optimized background therapy (OBT) [Oral presentation]
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September, Chicago, Illinois
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Zolopa AR, Lampiris H, Blick G, et al. The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable antiretroviral activity in treatment-experienced patients with active optimized background therapy (OBT) [Oral presentation]. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 17-20 September 2007; Chicago, Illinois.
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(2007)
47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 17-20
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Zolopa, A.R.1
Lampiris, H.2
Blick, G.3
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27
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67149091462
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Fasted lipid changes after administration of maraviroc or efavirenz in combination with zidovudine and lamivudine for 48 weeks to treatment-naive HIV-infected patients
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abstract 929, Presented at the February, Boston, Massachusetts
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DeJesus E, Walsmley S, Cohen C, et al. Fasted lipid changes after administration of maraviroc or efavirenz in combination with zidovudine and lamivudine for 48 weeks to treatment-naive HIV-infected patients [abstract 929]. Presented at the 15th Conference on Retroviruses and Opportunistic Infections; February 2008; Boston, Massachusetts.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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DeJesus, E.1
Walsmley, S.2
Cohen, C.3
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28
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35648950291
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Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 infection
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abstract 8, Presented at the 12-16 June, Barbados, West Indies
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Hazuda DJ, Miller MD, Nguyen BY, et al. Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 infection [abstract 8]. Presented at the XVI International HIV Drug Resistance Workshop: Basic Principles & Clinical Implications; 12-16 June 2007; Barbados, West Indies.
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(2007)
XVI International HIV Drug Resistance Workshop: Basic Principles & Clinical Implications
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Hazuda, D.J.1
Miller, M.D.2
Nguyen, B.Y.3
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