-
1
-
-
45149133036
-
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
-
DOI 10.1056/NEJMoa0802987
-
Advance Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;24:2560-2572 (Pubitemid 351831357)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.24
, pp. 2560-2572
-
-
Patel, A.1
MacMahon, S.2
Chalmers, J.3
Neal, B.4
Billot, L.5
Woodward, M.6
Marre, M.7
Cooper, M.8
Glasziou, P.9
Grobbee, D.10
Hamet, P.11
Harrap, S.12
Heller, S.13
Liu, L.14
Mancia, G.15
Mogensen, C.E.16
Pan, C.17
Poulter, N.18
Rodgers, A.19
Williams, B.20
Bompoint, S.21
De Galan, B.E.22
Joshi, R.23
Travert, F.24
more..
-
2
-
-
53749096863
-
10-year follow-up of intensive glucose control in type 2 diabetes
-
Holmann RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;15:1577-1589
-
(2008)
N Engl J Med
, vol.15
, pp. 1577-1589
-
-
Holmann, R.R.1
Paul, S.K.2
Bethel, M.A.3
-
3
-
-
34447267513
-
Efficacy and safety of incretin therapy in type 2 diabetes
-
Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes. JAMA 2007;298:194-206
-
(2007)
JAMA
, vol.298
, pp. 194-206
-
-
Amori, R.E.1
Lau, J.2
Pittas, A.G.3
-
4
-
-
55249092256
-
Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus
-
Moore KB, Saudek CD. Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus. Am J Ther 2008;15:484-491
-
(2008)
Am J Ther
, vol.15
, pp. 484-491
-
-
Moore, K.B.1
Saudek, C.D.2
-
5
-
-
12244260114
-
Glucagon-like peptide 1 (GLP-1) in the treatment of diabetes
-
DOI 10.1055/s-2004-826175
-
Nauck MA. Glucagon-like peptide 1 (GLP-1) in the treatment of diabetes. Horm Metab Res 2004;36:2-8 (Pubitemid 40115910)
-
(2004)
Hormone and Metabolic Research
, vol.36
, Issue.11-12
, pp. 852-858
-
-
Nauck, M.A.1
-
6
-
-
0027248866
-
Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
-
Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993;36:741-744
-
(1993)
Diabetologia
, vol.36
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
-
7
-
-
0037045845
-
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: A parallel-group study
-
DOI 10.1016/S0140-6736(02)07952-7
-
Zander M, Madsbad S, Madsen J, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study. Lancet 2002;359:824-830 (Pubitemid 34233752)
-
(2002)
Lancet
, vol.359
, Issue.9309
, pp. 824-830
-
-
Zander, M.1
Madsbad, S.2
Madsen, J.L.3
Holst, J.J.4
-
8
-
-
67649592948
-
No increased risk of hypoglycaemic episodes during 48 hours of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects
-
Oxf Epub ahead of print
-
Lerche S, Soendergaard L, Rungby J, et al. No increased risk of hypoglycaemic episodes during 48 hours of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects. Clin Endocrinol (Oxf) 2008 [Epub ahead of print]
-
(2008)
Clin Endocrinol
-
-
Lerche, S.1
Soendergaard, L.2
Rungby, J.3
-
9
-
-
34249902025
-
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: Preclinical biology and mechanisms of action
-
DOI 10.2337/dc07-0228
-
Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action. Diabetes Care 2007;30:1335-1343 (Pubitemid 46871135)
-
(2007)
Diabetes Care
, vol.30
, Issue.6
, pp. 1335-1343
-
-
Drucker, D.J.1
-
10
-
-
33749834648
-
DPP-4 inhibitors and their potential role in the management of type 2 diabetes
-
DOI 10.1111/j.1742-1241.2006.01178.x
-
Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract 2006;60:1454-1470 (Pubitemid 44560347)
-
(2006)
International Journal of Clinical Practice
, vol.60
, Issue.11
, pp. 1454-1470
-
-
Barnett, A.1
-
11
-
-
25844459084
-
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes. Potential importance of selectivity over dipeptidyl peptidases 8 and 9
-
Lankas GR, Leiting B, Roy RS, et al. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes. Potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 2005;54:2988-2994
-
(2005)
Diabetes
, vol.54
, pp. 2988-2994
-
-
Lankas, G.R.1
Leiting, B.2
Roy, R.S.3
-
12
-
-
48049092062
-
Adverse effects of dipeptidyl peptidases 8 & 9 inhibition in rodents revisited
-
Burkey BF, Hoffman PK, Hassiepen U, et al. Adverse effects of dipeptidyl peptidases 8 & 9 inhibition in rodents revisited. Diabetes Obes Metab 2008;10:1057-1061
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 1057-1061
-
-
Burkey, B.F.1
Hoffman, P.K.2
Hassiepen, U.3
-
13
-
-
0031916924
-
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
-
DOI 10.2337/diabetes.47.5.764
-
Deacon CF, Hughes TE, Holst JJ. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes 1998;47:764-769 (Pubitemid 28201806)
-
(1998)
Diabetes
, vol.47
, Issue.5
, pp. 764-769
-
-
Deacon, C.F.1
Hughes, T.E.2
Holst, J.J.3
-
14
-
-
0036583164
-
Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
-
Ahren B, Simonsson E, Larsson H, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002;5:869-875
-
(2002)
Diabetes Care
, vol.5
, pp. 869-875
-
-
Ahren, B.1
Simonsson, E.2
Larsson, H.3
-
15
-
-
53749085064
-
Incretin-based therapies in type 2 diabetes mellitus
-
Chia CW, Egan JM. Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab 2008;93:3703-3716
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3703-3716
-
-
Chia, C.W.1
Egan, J.M.2
-
16
-
-
41149118550
-
(R)-8-(3-amino-piperidin-1-yl)- 7-but-2-ynyl-3-methyl-1-(4-methyl- quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
-
Thomas L, Eckhardt M, Langkopf E, et al. (R)-8-(3-amino-piperidin-1-yl)- 7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2, 6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 2008;325:175-182
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 175-182
-
-
Thomas, L.1
Eckhardt, M.2
Langkopf, E.3
-
17
-
-
37349073397
-
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl- quinazolin- 2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
-
DOI 10.1021/jm701280z
-
Eckhardt M, Langkopf E, Mark M, et al. 8-(3-(R)-aminopiperidin-1-yl)-7- but-2-ynyl-3-methyl-1-(4-methyl-quinazolin- 2-ylmethyl)-3,7-dihydropurine-2,6- dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. J Med Chem 2007;50:6450-6453 (Pubitemid 350309082)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.26
, pp. 6450-6453
-
-
Eckhardt, M.1
Langkopf, E.2
Mark, M.3
Tadayyon, M.4
Thomas, L.5
Nar, H.6
Pfrengle, W.7
Guth, B.8
Lotz, R.9
Sieger, P.10
Fuchs, H.11
Himmelsbach, F.12
-
18
-
-
67649587102
-
Determination of the absolute bioavailability of BI 1356 a substance with non linear pharmacokinetics using a population pharmacokinetic modeling approach
-
abstract 1110.
-
Dittberner S, Duval V, Staab A, et al. Determination of the absolute bioavailability of BI 1356 a substance with non linear pharmacokinetics using a population pharmacokinetic modeling approach [abstract 1110]. 16th Meet Popul Approach Group Eur (June 13, Copenhagen) 2008
-
(2008)
16th Meet Popul Approach Group Eur (June 13, Copenhagen)
-
-
Dittberner, S.1
Duval, V.2
Staab, A.3
-
19
-
-
51849103389
-
Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers
-
Huttner S, Graefe-Mody EU, Withopf B, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers. J Clin Pharmacol 2008;48:1171-1178
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1171-1178
-
-
Huttner, S.1
Graefe-Mody, E.U.2
Withopf, B.3
-
20
-
-
67649580975
-
The novel DPP-4 inhibitor BI 1356 (Proposed radename ONDERO) and metformin can be safely co-administered without dose adjustment
-
Graefe-Mody U, Padula SJ, Dugi KA, et al. The novel DPP-4 inhibitor BI 1356 (Proposed radename ONDERO) and metformin can be safely co-administered without dose adjustment. Diabetes 2008;57:A164
-
(2008)
Diabetes
, vol.57
-
-
Graefe-Mody, U.1
Padula, S.J.2
Dugi, K.A.3
-
21
-
-
59649105751
-
Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin-1-yl)-7-but- 2-ynyl-3-methyl-1-(4-methyl-quinazolin-2- yl methyl)-3,7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide-1 and improves glycemic control in diabetic rodent models
-
Thomas L, Tadayyon M, Mark M. Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin-1-yl)-7-but- 2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydro-purine-2,6- dione] increases basal glucagon-like peptide-1 and improves glycemic control in diabetic rodent models. J Pharmacol Exp Ther 2009;328:556-563
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 556-563
-
-
Thomas, L.1
Tadayyon, M.2
Mark, M.3
-
22
-
-
67649623147
-
BI 1356, a novel and selective xanthine based DPP-IV inhibitor, exhibits a superior profile when compared to sitagliptin and vildagliptin
-
Thomas L, Himmelsbach F, Eckhardt M, et al. BI 1356, a novel and selective xanthine based DPP-IV inhibitor, exhibits a superior profile when compared to sitagliptin and vildagliptin. Diabetologia 2007;50:S363
-
(2007)
Diabetologia
, vol.50
-
-
Thomas, L.1
Himmelsbach, F.2
Eckhardt, M.3
-
23
-
-
67649601495
-
Safety, Tolerability and pharmacodynamics of single and multiple oral doses of the dipeptidyl peptidase 4 inhibitor BI 1356 in healthy Japanese volunteers
-
Sesoko S, Nakajima M, Hayashi N, et al. Safety, Tolerability and pharmacodynamics of single and multiple oral doses of the dipeptidyl peptidase 4 inhibitor BI 1356 in healthy Japanese volunteers. Diabetes 2008;57:A159
-
(2008)
Diabetes
, vol.57
-
-
Sesoko, S.1
Nakajima, M.2
Hayashi, N.3
-
24
-
-
51749107972
-
BI-1356 - Dipeptidyl-peptidase IV inhibitor, antidiabetic agent
-
Wang Y. BI-1356 - dipeptidyl-peptidase IV inhibitor, antidiabetic agent. Drugs Future 2008;33:1171-1178
-
(2008)
Drugs Future
, vol.33
, pp. 1171-1178
-
-
Wang, Y.1
-
25
-
-
42649121910
-
The novel, potent, and selective DPP-IV inhibitor B1 1356 significantly lowers HbA1c after only 4 weeks of treatment in patients with type 2 diabetes
-
Forst T, Uhlig-Laske B, Ring A, et al. The novel, potent, and selective DPP-IV inhibitor B1 1356 significantly lowers HbA1c after only 4 weeks of treatment in patients with type 2 diabetes. Diabetes 2007;56:A157-8
-
(2007)
Diabetes
, vol.56
-
-
Forst, T.1
Uhlig-Laske, B.2
Ring, A.3
-
26
-
-
42649118747
-
Treatment with BI 1356, a novel and potent DPP-IV inhibitor, significantly reduces glucose excursions after an oGTT in patients with type 2 diabetes
-
Heise T, Tiessen R, Hüttner, et al. Treatment with BI 1356, a novel and potent DPP-IV inhibitor, significantly reduces glucose excursions after an oGTT in patients with type 2 diabetes. Diabetes 2007;56:A156
-
(2007)
Diabetes
, vol.56
-
-
Heise, T.1
Tiessen, R.2
Hüttner3
|