Ear drops for the removal of ear wax

Cochrane Database of Systematic Reviews

Volumn , Issue 1, 2009, Pages

  Burton, Martin J ^a   Doree, Carolyn ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Cerumen *drug effects ; Detergents administration dosage ; Humans; Randomized controlled trials as topic; Solvents *administration dosage ; Syringes

Indexed keywords

ALMOND OIL; ARACHIS OIL; AUDAX; BICARBONATE; CAMPHOR; CERUMINOLYTIC AGENT; CERUMOL; CHOLINE SALICYLATE; DOCUSATE SODIUM; EAR DROPS; EAREX; EXTEROL; GLYCEROL; HYDROGEN PEROXIDE; OLIVE OIL; OTOCEROL; PLACEBO; TRIETHANOLAMINE; TRIETHANOLAMINE OLEYLPOLYPEPTIDE; UNCLASSIFIED DRUG; WATER;

BLEEDING; CERUMEN IMPACTION; CINAHL; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CLINICAL TRIAL; COCHRANE LIBRARY; DRUG EFFICACY; EMBASE; EVENING DOSAGE; EXTERNAL AUDITORY CANAL; HEARING LOSS; HUMAN; MEDLINE; NAUSEA; OTOSCOPY; OUTCOME ASSESSMENT; PAIN; REVIEW; UNSPECIFIED SIDE EFFECT; VERTIGO;

EID: 67649569202     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD004326.pub2     Document Type: Review

References (50)

1. Fahmy S, Whitefield M. Multicentre clinical trial of Exterol® as a cerumenolytic. British Journal of Clinical Practice 1982;36(5):197-204.
2. Fahmy S, Whitefield M. Multicentre clinical trial of Exterol® as a cerumenolytic. British Journal of Clinical Practice 1982;36(5):197-204.
3. Fahmy S, Whitefield M. Multicentre clinical trial of Exterol® as a cerumenolytic. British Journal of Clinical Practice 1982;36(5):197-204.
4. Jaffe G, Grimshaw J. A multicentric clinical trial comparing Otocerol® with Cerumol® as cerumenolytics. Journal of International Medical Research 1978;6:241-244 (Pubitemid 8348585)
5. Keane EM. Personal correspondence (email) 27 March 2003.
6. * Keane EM, Wilson H, McGrane D, Coakley D, Walsh JB. Use of solvents to disperse ear wax. British Journal of Clinical Practice 1995; 49(2):71-72
7. Lyndon S, Roy P, Grillage MG, Miller AJ. A comparison of the efficacy of two ear drop preparations (Audax® and Earex® ) in the softening and removal of impacted ear wax. Current Medical Research Opinions 1992;13:21-25 (Pubitemid 23016568)
8. Meehan P. Personal correspondence (email) 18 April 2003. *
9. Meehan P, Isenhour JL, Reeves R, Wrenn K. Ceruminolysis in the pediatric patient: a prospective, double-blinded, randomized controlled trial. Academic Emergency Medicine 2002;9(5):521-522
10. Robinson A. Docusate sodium with irrigation was better than triethanolamine polypeptide with irrigation for dissolving earwax. Evidence-Based Nursing 2001;4(2):48.
11. * Singer AJ, Sauris E, Viccellio AW. Ceruminolytic effects of docusate sodium: a randomized, controlled trial. Annals of Emergency Medicine 2000;36(3):228-232
12. Whatley VN, Dodds CL, Paul RI. Randomized clinical trial of docusate, triethanolamine polypeptide, and irrigation in cerumen removal in children. Archives of Paediatrics and Adolescent Medicine 2003;157(12):1177-1180
13. Amjad AH, Scheer AA. Clinical evaluation of cerumenolytic agents. Eye, Ear, Nose and Throat Monthly 1975;54:74-76
14. Baker BS. A clinical trial of a ceruminolytic agent. Transactions of the Society for Occupational Medicine 1969;19:62-63
15. Burgess EH. A wetting agent to facilitate ear syringing. The Practitioner 1966;197(182):811-812
16. Carr MM, Smith RL. Ceruminolytic efficacy in adults versus children. Journal of Otolaryngology 2001;30(3):154-156 (Pubitemid 34269932)
17. Chaput de Saintonge DM, Johnstone CI. A clinical comparison of triethanolamine polypeptide oleate-condensate ear drops with olive oil for the removal of impacted wax. British Journal of Clinical Practice 1973;27:454-455
18. Dubow E. A simple method to assure proper pediatric ear examinations. Archives of Pediatrics 1959;76:360-363
19. Dummer DS, Sutherland IA,Murray JA. A single-blind, randomized study to compare the efficacy of two ear drop preparations (Audax® and Cerumol® ) in the softening of ear wax. Current Medical Research Opinions 1992;13:26-30. (Pubitemid 23016569)
20. Eekhof JA, de Bock GH, Le Cessie S, Springer MP. A quasi-randomised controlled trial of water as a quick softening agent of persistent earwax in general practice. British Journal of General Practice 2001;51(469):635-637 (Pubitemid 32725250)
21. Fraser, JG. The efficacy of wax solvents: in vitro studies and a clinical trial. Journal of Laryngology and Otology 1970;84:1055-1064
22. General Practitioner Research Group. A wetting agent to facilitate ear syringing. The Practitioner 1965;195:810-812
23. General Practitioner Research Group. Wax softening with a new preparation. The Practitioner 1967;199:359-362
24. Hewitt HR. Clinical evaluation of choline salicylate ear-drops. The Practitioner 1970;204:438-440
25. Hinchcliffe R. Effect of current cerumenolytics. British Medical Journal 1955;2:722.
26. Pavlidis C, Pickering JA. Water as a fast acting wax softening agent before ear syringing. Australian Family Physician 2005;34(4):303-304
27. Proudfoot J.Clinical trial of a ceruminolytic agent in general practice. British Journal of Clinical Practice February 1968;22(2):69-70.
28. Roland PS, Eaton DA, Gross RD, Wall GM, Conroy PJ, Garadi R, et al.Randomized, placebo-controlled evaluation of Cerumenex and Murine earwax removal products. Archives of Otolaryngology - Head and Neck Surgery 2004;130(10):1175-1177 (Pubitemid 39371962)
29. Spiro S. A cost-effectiveness analysis of earwax softeners. Nurse Practitioner 1997;22(8):28-31,166.
30. Caballero M, Navarrete P, Domenech J, Bernal-Sprekelsen M. Randomized clinical trial of clorobutanol, sodium carbonate, and irrigation in cerumen removal in adults. Proceedings of the XVIII IFOS World Congress. 2005:Abstract No. F27.
31. Schroeder K. Controlled clinical trial of olive oil versus ear irrigation for the removal of ear wax in primary care (CLEAR). National Research Register 2006. [: N0632169201]
32. Anonymous. Ear wax solvents compared. Drug and Therapeutics Bulletin 1971;9(4):15-16
33. Brister F, Fullwood HL, Ripp T, Blodgett C. Incidence of occlusion due to impacted cerumen among mentally retarded adolescents. American Journal of Mental Deficiency 1990;15:594-600. (Pubitemid 17181292)
34. Chalmers I, Adams M, Dickersin K, Hetherington J, Tarnow-Mordi W,Meinert C, et al.A cohort study of summary reports of controlled trials. JAMA 1990;263:1401-1405 (Pubitemid 20069948)
35. Dinsdale RC, Roland PS,Manning SC. Catastrophic otologic injury from oral jet irrigation of the external auditory canal. Laryngoscope 1991;101:75-78
36. Driver C. Removal or ear wax. Australian Family Physician 1999;28 (12):1215.
37. Grossan Murray M. Safe, effective techniques for cerumen removal. Geriatrics 2000;55(1):80-86
38. Higgins J, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]. The Cochrane Library, Issue 2, 2008. Chichester: John Wiley and Sons, Ltd, 2006.
39. Kalantan KA, Addulghani H, Al-Taweel AA, Al-Serhane AM. Use of cotton tipped swab and cerumen impaction. Indian Journal of Otolaryngology 1999;5,1:27-31. (Pubitemid 29253705)
40. Lewis-Cullinan C, Janken JK. The effect of cerumen removal on the hearing ability of geriatric patients. Journal of Advanced Nursing 1990;15:594-600.
41. Masterson E, Seaton TL. How does liquid docusate sodium (Colace® ) compare with triethanolamine polypeptide as a ceruminolytic for acute earwax removal?. Journal of Family Practice December 2000;49(12):1076.
42. Minja BM, Machemba A. Prevalence of otitis media, hearing impairment and cerumen impaction among school children in rural and urban Dar es Salaam, Tanzania. International Journal of Paediatric Otorhinolaryngology 1996;37:29-34. (Pubitemid 26279167)
43. Prasad KS. Cardiac depression on syringing the ear. Journal of Laryngology and Otology 1984;98:1013.
44. Robinson AC, Hawke M. The efficacy of ceruminoytics: everything old is new again. Journal of Otolaryngology 1989;18(6):263-267 (Pubitemid 19261924)
45. Saloranta K, Westermarck T. Prevention of cerumen impaction by treatment of ear canal skin. A pilot randomized controlled study. Clinical Otolaryngology 2005;30(2):112-114 (Pubitemid 40559438)
46. Seely DR, Quigley SM, Langmann AW. Ear candles - efficacy and safety. Laryngoscope 1996;106:1226-1229
47. Sharp JF, Wilson JA, Ross L, Barr-Hamilton RM. Ear wax removal: a survey of current practice. BMJ 1990;301:1251-1252
48. Swart SM, Lemmer R, Parbhoo JN, Prescolt CAJ. A survey of ear and hearing disorders amongst a representative sample of Grade 1 school children in Swaziland. International Journal of Pediatric Otorhinolaryngology 1995;32:23-34.
49. Zikk D, Rappaport Y, Himelfarb MZ. Invasive external otitis after removal of impacted cerumen by irrigation. New England Medical Journal 1991;325:969-970
50. Zivic RC, King S. Cerumen-impaction management for clients of all ages. Nurse Practitioner 1993;18(3):29-39.