-
1
-
-
0037191716
-
Typhoid Fever
-
Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ (2002) Typhoid Fever. N Engl J Med 347: 1770-1782.
-
(2002)
N Engl J Med
, vol.347
, pp. 1770-1782
-
-
Parry, C.M.1
Hien, T.T.2
Dougan, G.3
White, N.J.4
Farrar, J.J.5
-
3
-
-
0018841829
-
Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
-
O'Brien AD, Rosenstreich DL, Scher I, Campbell GH, MacDermott RP, et al. (1980) Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol 124: 20-24.
-
(1980)
J Immunol
, vol.124
, pp. 20-24
-
-
O'Brien, A.D.1
Rosenstreich, D.L.2
Scher, I.3
Campbell, G.H.4
MacDermott, R.P.5
-
4
-
-
0014425756
-
Genetic control of leucocyte responses to endotoxin
-
Sultzer BM (1968) Genetic control of leucocyte responses to endotoxin. Nature 219: 1253-1254.
-
(1968)
Nature
, vol.219
, pp. 1253-1254
-
-
Sultzer, B.M.1
-
5
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Huffel, C.V.5
-
6
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
-
(1999)
J Immunol
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
-
7
-
-
0035674724
-
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection
-
Bernheiden M, Heinrich JM, Minigo G, Schutt C, Stelter F, et al. (2001) LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res 7: 447-450.
-
(2001)
J Endotoxin Res
, vol.7
, pp. 447-450
-
-
Bernheiden, M.1
Heinrich, J.M.2
Minigo, G.3
Schutt, C.4
Stelter, F.5
-
8
-
-
1642317049
-
Toll-like receptors are temporally involved in host defense
-
Weiss DS, Raupach B, Takeda K, Akira S, Zychlinsky A (2004) Toll-like receptors are temporally involved in host defense. J Immunol 172: 4463-4469.
-
(2004)
J Immunol
, vol.172
, pp. 4463-4469
-
-
Weiss, D.S.1
Raupach, B.2
Takeda, K.3
Akira, S.4
Zychlinsky, A.5
-
9
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
10
-
-
0034886143
-
Toll-like receptors: Critical proteins linking innate and acquired immunity
-
Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680.
-
(2001)
Nat Immunol
, vol.2
, pp. 675-680
-
-
Akira, S.1
Takeda, K.2
Kaisho, T.3
-
11
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191.
-
(2000)
Nat Genet
, vol.25
, pp. 187-191
-
-
Arbour, N.C.1
Lorenz, E.2
Schutte, B.C.3
Zabner, J.4
Kline, J.N.5
-
12
-
-
0037866985
-
Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling
-
Erridge C, Stewart J, Poxton IR (2003) Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 197: 1787-1791.
-
(2003)
J Exp Med
, vol.197
, pp. 1787-1791
-
-
Erridge, C.1
Stewart, J.2
Poxton, I.R.3
-
13
-
-
0037071251
-
Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
-
Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162: 1028-1032.
-
(2002)
Arch Intern Med
, vol.162
, pp. 1028-1032
-
-
Lorenz, E.1
Mira, J.P.2
Frees, K.L.3
Schwartz, D.A.4
-
14
-
-
2542485274
-
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease
-
Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, et al. (2004) Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 189: 2057-2063.
-
(2004)
J Infect Dis
, vol.189
, pp. 2057-2063
-
-
Tal, G.1
Mandelberg, A.2
Dalal, I.3
Cesar, K.4
Somekh, E.5
-
15
-
-
14044259411
-
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
-
Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, et al. (2005) Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A 102: 2487-2489.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2487-2489
-
-
Hawn, T.R.1
Verbon, A.2
Janer, M.3
Zhao, L.P.4
Beutler, B.5
-
16
-
-
30444459750
-
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
-
Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J, et al. (2006) Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A 103: 177-182.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 177-182
-
-
Mockenhaupt, F.P.1
Cramer, J.P.2
Hamann, L.3
Stegemann, M.S.4
Eckert, J.5
-
17
-
-
7544221703
-
The toll-like receptor 4 Asp299Gly variant: No influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia
-
Newport MJ, Allen A, Awomoyi AA, Dunstan SJ, McKinney E, et al. (2004) The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia. Tuberculosis (Edinb) 84: 347-352.
-
(2004)
Tuberculosis (Edinb)
, vol.84
, pp. 347-352
-
-
Newport, M.J.1
Allen, A.2
Awomoyi, A.A.3
Dunstan, S.J.4
McKinney, E.5
-
18
-
-
0035450762
-
A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease
-
Read RC, Pullin J, Gregory S, Borrow R, Kaczmarski EB, et al. (2001) A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J Infect Dis 184: 640-642.
-
(2001)
J Infect Dis
, vol.184
, pp. 640-642
-
-
Read, R.C.1
Pullin, J.2
Gregory, S.3
Borrow, R.4
Kaczmarski, E.B.5
-
19
-
-
0037947560
-
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
-
Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, et al. (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A 100: 6075-6080.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 6075-6080
-
-
Smirnova, I.1
Mann, N.2
Dols, A.3
Derkx, H.H.4
Hibberd, M.L.5
-
20
-
-
0034858250
-
Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans
-
Smirnova I, Hamblin MT, McBride C, Beutler B, Di Rienzo A (2001) Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics 158: 1657-1664.
-
(2001)
Genetics
, vol.158
, pp. 1657-1664
-
-
Smirnova, I.1
Hamblin, M.T.2
McBride, C.3
Beutler, B.4
Di Rienzo, A.5
-
21
-
-
20144366015
-
Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam
-
Dunstan SJ, Hawn TR, Hue NT, Parry CP, Ho VA, et al. (2005) Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. J Infect Dis 191: 1068-1071.
-
(2005)
J Infect Dis
, vol.191
, pp. 1068-1071
-
-
Dunstan, S.J.1
Hawn, T.R.2
Hue, N.T.3
Parry, C.P.4
Ho, V.A.5
-
22
-
-
0035863579
-
Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam
-
Dunstan SJ, Stephens HA, Blackwell JM, Duc CM, Lanh MN, et al. (2001) Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. J Infect Dis 183: 261-268.
-
(2001)
J Infect Dis
, vol.183
, pp. 261-268
-
-
Dunstan, S.J.1
Stephens, H.A.2
Blackwell, J.M.3
Duc, C.M.4
Lanh, M.N.5
-
23
-
-
15544369643
-
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
-
Schroder NW, Schumann RR (2005) Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 5: 156-164.
-
(2005)
Lancet Infect Dis
, vol.5
, pp. 156-164
-
-
Schroder, N.W.1
Schumann, R.R.2
-
24
-
-
0036950351
-
Single nucleotide polymorphisms in innate immunity genes: Abundant variation and potential role in complex human disease
-
Lazarus R, Vercelli D, Palmer LJ, Klimecki WJ, Silverman EK, et al. (2002) Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev 190: 9-25.
-
(2002)
Immunol Rev
, vol.190
, pp. 9-25
-
-
Lazarus, R.1
Vercelli, D.2
Palmer, L.J.3
Klimecki, W.J.4
Silverman, E.K.5
-
26
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
27
-
-
0033648133
-
Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4)
-
Smirnova I, Poltorak A, Chan EK, McBride C, Beutler B (2000) Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol 1.
-
(2000)
Genome Biol
, vol.1
-
-
Smirnova, I.1
Poltorak, A.2
Chan, E.K.3
McBride, C.4
Beutler, B.5
-
28
-
-
27644566207
-
Deeper into the genome
-
Gibbs R (2005) Deeper into the genome. Nature 437: 1233-1234.
-
(2005)
Nature
, vol.437
, pp. 1233-1234
-
-
Gibbs, R.1
-
29
-
-
0036799545
-
The allelic architecture of human disease genes: Common disease-common variant.or not?
-
Pritchard JK, Cox NJ (2002) The allelic architecture of human disease genes: common disease-common variant.or not? Hum Mol Genet 11: 2417-2423.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2417-2423
-
-
Pritchard, J.K.1
Cox, N.J.2
-
30
-
-
0035451780
-
On the allelic spectrum of human disease
-
Reich DE, Lander ES (2001) On the allelic spectrum of human disease. Trends Genet 17: 502-510.
-
(2001)
Trends Genet
, vol.17
, pp. 502-510
-
-
Reich, D.E.1
Lander, E.S.2
-
31
-
-
22544455705
-
A comparison of case-control and family-based association methods: The example of sickle-cell and malaria
-
Ackerman H, Usen S, Jallow M, Sisay-Joof F, Pinder M, et al. (2005) A comparison of case-control and family-based association methods: the example of sickle-cell and malaria. Ann Hum Genet 69: 559-565.
-
(2005)
Ann Hum Genet
, vol.69
, pp. 559-565
-
-
Ackerman, H.1
Usen, S.2
Jallow, M.3
Sisay-Joof, F.4
Pinder, M.5
-
32
-
-
0036605901
-
IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria
-
Koch O, Awomoyi A, Usen S, Jallow M, Richardson A, et al. (2002) IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. J Infect Dis 185: 1684-1687.
-
(2002)
J Infect Dis
, vol.185
, pp. 1684-1687
-
-
Koch, O.1
Awomoyi, A.2
Usen, S.3
Jallow, M.4
Richardson, A.5
-
33
-
-
0037018768
-
MBL genotype and risk of invasive pneumococcal disease: A case-control study
-
Roy S, Knox K, Segal S, Griffiths D, Moore CE, et al. (2002) MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 359: 1569-1573.
-
(2002)
Lancet
, vol.359
, pp. 1569-1573
-
-
Roy, S.1
Knox, K.2
Segal, S.3
Griffiths, D.4
Moore, C.E.5
-
34
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
The Wellcome Trust Case Control Consortium
-
The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
35
-
-
57649114759
-
-
The Malaria Genomic Epidemiology Network (2008) A global network for investigating the genomic epidemiology of malaria. Nature 456: 732-737.
-
The Malaria Genomic Epidemiology Network (2008) A global network for investigating the genomic epidemiology of malaria. Nature 456: 732-737.
-
-
-
-
36
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
37
-
-
0031905311
-
A family of human receptors structurally related to Drosophila Toll
-
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (1998) A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A 95: 588-593.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 588-593
-
-
Rock, F.L.1
Hardiman, G.2
Timans, J.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
38
-
-
0034456693
-
Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
-
Du X, Poltorak A, Wei Y, Beutler B (2000) Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 11: 362-371.
-
(2000)
Eur Cytokine Netw
, vol.11
, pp. 362-371
-
-
Du, X.1
Poltorak, A.2
Wei, Y.3
Beutler, B.4
-
39
-
-
0032100444
-
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
-
Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, et al. (1998) Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91: 4020-4027.
-
(1998)
Blood
, vol.91
, pp. 4020-4027
-
-
Chaudhary, P.M.1
Ferguson, C.2
Nguyen, V.3
Nguyen, O.4
Massa, H.F.5
-
41
-
-
17644399823
-
Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression
-
Roger T, Miconnet I, Schiesser AL, Kai H, Miyake K, et al. (2005) Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression. Biochem J 387: 355-365.
-
(2005)
Biochem J
, vol.387
, pp. 355-365
-
-
Roger, T.1
Miconnet, I.2
Schiesser, A.L.3
Kai, H.4
Miyake, K.5
-
42
-
-
9144271703
-
Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
-
Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, et al. (2004) Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J Immunol 173: 6949-6954.
-
(2004)
J Immunol
, vol.173
, pp. 6949-6954
-
-
Hyakushima, N.1
Mitsuzawa, H.2
Nishitani, C.3
Sano, H.4
Kuronuma, K.5
-
43
-
-
1342278730
-
Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events
-
Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, et al. (2003) Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 23: e61-64.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
-
-
Ameziane, N.1
Beillat, T.2
Verpillat, P.3
Chollet-Martin, S.4
Aumont, M.C.5
-
44
-
-
32344449064
-
Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain
-
Nishiya T, Kajita E, Miwa S (2006) Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain. Biochem Biophys Res Commun 341: 1128-1134.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 1128-1134
-
-
Nishiya, T.1
Kajita, E.2
Miwa, S.3
-
45
-
-
0038202199
-
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
-
Child NJ, Yang IA, Pulletz MC, de Courcy-Golder K, Andrews AL, et al. (2003) Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem Soc Trans 31: 652-653.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 652-653
-
-
Child, N.J.1
Yang, I.A.2
Pulletz, M.C.3
de Courcy-Golder, K.4
Andrews, A.L.5
-
46
-
-
8744301714
-
TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury
-
Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, et al. (2004) TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet 41: 808-813.
-
(2004)
J Med Genet
, vol.41
, pp. 808-813
-
-
Barber, R.C.1
Aragaki, C.C.2
Rivera-Chavez, F.A.3
Purdue, G.F.4
Hunt, J.L.5
-
47
-
-
0345708247
-
Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children
-
Allen A, Obaro S, Bojang K, Awomoyi AA, Greenwood BM, et al. (2003) Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children. Pediatr Infect Dis J 22: 1018-1019.
-
(2003)
Pediatr Infect Dis J
, vol.22
, pp. 1018-1019
-
-
Allen, A.1
Obaro, S.2
Bojang, K.3
Awomoyi, A.A.4
Greenwood, B.M.5
|