Hypofractionated Intensity-Modulated Radiotherapy for Carcinoma of the Prostate: Analysis of Toxicity

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 4, 2009, Pages 1121-1127

  Coote, Joanna H ^a   Wylie, James P ^a   Cowan, Richard A ^a   Logue, John P ^a   Swindell, Ric ^a   Livsey, Jacqueline E ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Dose escalation; Hypofractionation; IMRT; Late toxicity; Prostate cancer

Indexed keywords

DOSE ESCALATION; HYPOFRACTIONATION; IMRT; LATE TOXICITY; PROSTATE CANCER;

PHYSICAL THERAPY; RADIOTHERAPY;

TOXICITY;

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; BLADDER DISEASE; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; ENTEROPATHY; FEMALE; GLEASON SCORE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; DOSE FRACTIONATION; HUMANS; INTESTINES; MALE; MIDDLE AGED; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY, INTENSITY-MODULATED; URINARY BLADDER;

EID: 67649544143     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.09.032     Document Type: Article

References (19)

1. Kuban D.A., Tucker S.L., Dong L., et al. Long-term results of M.D. Anderson randomized dose escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys 71 (2008) 1288-1299
2. Hanks G.E., Hanlon A.L., Epstein B., and Horwitz E.M. Dose response in prostate cancer with 8-12 years follow-up. Int J Radiat Oncol Biol Phys 54 (2002) 427-435
3. Zelefsky M.J., Fuks Z., Hunt M., et al. High-dose intensity modulated radiation therapy for prostate cancer: Early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 53 (2002) 1111-1116
4. Morgan P.B., Hanlon A.L., Horwitz E.M., et al. Radiation dose and late failure in prostate cancer. Int J Radiat Oncol Biol Phys 67 (2007) 1074-1081
5. Lyons J.A., Kupelian P.A., Mohan D.S., et al. Importance of high radiation doses (72Gy or greater) in treatment of stage T1-3 adenocarcinoma prostate. Urol 55 (2000) 85-90
6. Logue J.P., Cowan R.A., and Hendry J.H. Hypofractionation for prostate cancer. Int J Radiat Oncol Biol Phys 49 (2001) 1522-1523
7. Amer A.M., Mott J., Mackay R.I., et al. Prediction of the benefits from dose-escalated hypofractionated intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 56 (2003) 199-207
8. Livsey J.E., Routledge J., Burns M., et al. Scoring of treatment related late effects in prostate cancer. Radiother Oncol 65 (2002) 109-121
9. Livsey J.E., Cowan R.A., Wylie J.P., et al. Hypofractionated conformal radiotherapy in carcinoma of the prostate: 5 year outcome analysis. Int J Radiat Oncol Biol Phys 57 (2003) 1254-1259
10. Dearnaley D.P., Sydes M.R., Langley R.E., et al. The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localized prostate cancer: Results from the MRC RT01 trial. Radiother Oncol 83 (2007) 31-41
11. Dearnaley D.P., Sydes M.R., Graham J.D., et al. Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomised controlled trial. Lancet Oncol 8 (2007) 475-487
12. Mott J.H., Livsey J.E., and Logue J.P. Development of a simultaneous boost IMRT class solution for a hypofractionated prostate cancer protocol. British J Radiol 77 (2004) 377-386
13. Kupelian P.A., Reddy C.A., Carlson T.P., et al. Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer. Int J Radiat Oncol Biol Phys 53 (2002) 904-912
14. Catton C.N., Chung P., Haycocks T., et al. Hypofractionated intensity modulated radiation therapy for prostate cancer. Int J Rad Oncol Biol Phys 54 Suppl (2002) 1051
15. Pollack A., Hanlon A.L., Horwitz E.M., et al. Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial. Int J Radiat Oncol Biol Phys 64 (2006) 518-526
16. Kupelian P.A., Thakkar V.V., Khuntia D., et al. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Long-term outcomes. Int J Radiat Oncol Biol Phys 63 (2005) 1463-1468
17. Kupelian P.A., Willoughby T.R., Reddy C.A., et al. Hypofractionated Intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland clinic experience. Int J Radiat Oncol Biol Phys 68 (2007) 1424-1430
18. Zelefsky M.J., Chan H., Hunt M., et al. Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer. J Urol 176 (2006) 1415-1419
19. Conventional or hypofractionated high dose intensity modulated radiotherapy for prostate cancer (chHip). Available at: http://clinicaltrials.gov/show/NCT00392535. Accessed October 28, 2008.